| Identification |
|---|
| BMDB Protein ID
| BMDBP00403 |
| Secondary Accession Numbers
| None |
| Name
| S-adenosylmethionine synthase isoform type-1 |
| Synonyms
|
Not Available
|
| Gene Name
| MAT1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. |
| Pathways
|
- Amino-acid biosynthesis
- Betaine Metabolism
- Methionine Metabolism
- S-adenosyl-L-methionine biosynthesis
- S-adenosyl-L-methionine from L-methionine: step 1/1
- Selenoamino Acid Metabolism
- Spermidine and Spermine Biosynthesis
|
| Reactions
|
| Selenomethionine + Adenosine triphosphate + Water → Se-Adenosylselenomethionine + Hydrogen phosphate + Pyrophosphate |
details
|
| Adenosine triphosphate + L-Methionine + Water → S-Adenosylmethionine + Hydrogen phosphate + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| MAT1A |
| Gene Sequence
|
>1191 bp
ATGAATGGACCAGTGGATGGCTTGTGTGATCATTCTCTAAGTGAGGAAGGAGCATTCATG
TTCACATCGGAATCTGTAGGAGAGGGGCACCCGGATAAGATCTGTGACCAGATCAGTGAT
GCAGTGCTGGATGCCCATCTCAAGCAGGACCCCAATGCCAAGGTGGCCTGTGAGACGGTG
TGTAAGACGGGCATGGTGCTTCTGTGCGGGGAGATCACCTCCATGGCCATGGTGGATTAC
CAGCGTGTGGTGCGGGAGACCATCCAGCACATCGGCTACGACGACTCCGCCAAGGGCTTT
GACTTTAAGACCTGCAACGTGCTGGTGGCTTTGGAGCAGCAGTCCCCGGATATCGCCCAG
TGTGTCCACCTGGACAGAAATGAAGAGGATGTCGGTGCCGGAGATCAGGGGCTGATGTTT
GGCTATGCCACGGATGAGACGGAAGAGTGCATGCCCCTCACCATCATGCTGGCGCACAGA
CTCAACGCCCGCATGGCAGAGCTGCGACGCTCAGGGCAGCTCCCCTGGCTGCAACCTGAC
TCCAAGACACAGGTGACAGTGCAGTACACGCAGGACAACGGTGCGGTCATCCCTATGCGC
GTCCATACCGTCGTCATCTCCGTGCAGCACAACGAAGACATAACGCTGGAGGACATGCGC
AGAGCCCTGAAGGAGCAGGTGATCAGGGCTGTTGTGCCAGCACGGTACCTGGACGAGGAC
ACCATCTACCACCTGCAGCCCAGTGGGCGCTTTGTCATCGGAGGCCCCCAGGGGGATGCC
GGTGTCACTGGCCGAAAGATCATCGTGGACACCTATGGCGGCTGGGGGGCACACGGCGGA
GGCGCCTTCTCTGGGAAGGACTACACCAAGGTGGACCGCTCGGCAGCGTACGCTGCCCGC
TGGGTGGCCAAGTCCCTGGTGAAAGCAGGGCTCTGCCGGAGGGTGCTTGTGCAGGTGTCC
TATGCCATTGGTGTGGCTGAGCCACTGTCTATTTCCATCTTTACCTATGGAACCTCCCAG
AAGACAGAGAGAGAGCTGCTGGATGTGGTCAATAAGAACTTTGACCTTCGGCCTGGTGTT
ATCGTCAGGGACTTGGACTTGAAGAAGCCCATCTACCAGAAGACAGCATGCTACGGCCAC
TTCGGGAGGAGCGAGTTCCCTTGGGAAGTTCCCAAAAAGCTTGTGTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 396 |
| Molecular Weight
| 43761.0 |
| Theoretical pI
| 5.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>S-adenosylmethionine synthetase isoform type-1
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMVDYQRVVRETIQHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIMLAHRLNARMAELRRSGQLPWLQPD
SKTQVTVQYTQDNGAVIPMRVHTVVISVQHNEDITLEDMRRALKEQVIRAVVPARYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSQKTERELLDVVNKNFDLRPGV
IVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
|
| External Links |
|---|
| GenBank ID Protein
| AAI05411.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJC6 |
| UniProtKB/Swiss-Prot Entry Name
| METK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC105410 |
| GeneCard ID
| MAT1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
