<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:22:15 UTC</creation_date>
  <update_date>2020-05-20 21:04:42 UTC</update_date>
  <accession>BMDBP00410</accession>
  <secondary_accessions>
    <accession>BMDBP03126</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>ASMT</gene_name>
  <general_function>Secondary metabolites biosynthesis, transport and catabolism</general_function>
  <specific_function>Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).</specific_function>
  <pathways>
    <pathway>
      <name>Aromatic compound metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Melatonin biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Melatonin from serotonin: step 1/2</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000939</accession>
      <name>S-Adenosylhomocysteine</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001185</accession>
      <name>S-Adenosylmethionine</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001238</accession>
      <name>N-Acetylserotonin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001389</accession>
      <name>Melatonin</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000763</accession>
      <name>5-Hydroxyindoleacetic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0004096</accession>
      <name>5-Methoxyindoleacetate</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>1</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1053 bp
AGCCAGACCGGCCCAGAAGGAAGATGTGCTCCCAGGAGGGTGAGGGCTACAGTCTCCTGA
AGGAATACGCCAACGCGTTCATGGTCTCCCAGGTTCTCTTTGCTGCCTGTGAGCTGGGGG
TGTTTGAGCTCCTGGCAGAGGCCCTGGAGCCCCTGGACTCAGCAGCAGTGTCTTCACATC
TGGGCTCCAGCCCAGGGGACAGAGCTGCTACTGAACACCTGTGTGTCCCTGAAGCTGCTG
CAAGCCGACGTGAGGGGAGGAAAAGCTGTGTATGCAAACACGGAGCTCGCCAGCACCTAC
CTGGTGAGAGGCAGCCCCAGGTCCCAGCGGGACATGCTGCTGTACGCGGGCAGGACCGCT
TACGTCTGCTGGCGCCACCTGGCGAGGCAGTCAGGGAAGGGAGGAACCAGTATCTGAAAG
CCTTCGGGATCCCGTCCGAGGAGCTCTTCTCTGCCATCTACAGGTCTGAGGACGAAAGGC
TGCAGTTCATGCAGGGTCTGCAGGACGTGTGGAGGCTGGAGGGGGCGACGGTGCTGGCCG
CCTTCGACCTGTCCCCCTTCCCGCTCATCTGCGACCTGGGGGGCGGTTCTGGGGCTCTGG
CCAAGGCGTGCGTGTCCCTGTACCCGGGATGTCGGGCCATTGTGTTCGACATCCCAGGAG
TGGTGCAGATCGCCAAGAGACATTTCTCAGCCTCGGAGGACGAGCGCATCAGCTTCCATG
AAGGGGATTTCTTCAAAGACGCCCTCCCGGAGGCGGACCTGTATATCCTGGCCAGGGTCC
TGCATGACTGGACCGATGCCAAGTGCTCCCACCTGCTGCAGAGAGTCTATCGGGCCTGCA
GGACAGGTGGCGGCATCCTGGTCATCGAGAGCCTCCTGGACACGGACGGGCGGGGCCCTC
TGACCACGCTGCTGTACTCGCTGAACATGCTGGTGCAAACGGAGGGCCGTGAGCGGACCC
CCGGCCGAAGTACCGCGCGCTCCGTGGGCCCCGCCGCTTCCGAGACGTGCGGTGACGGAG
GACGGGGGGAACCTACGATGCTGTCTTGGCCAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>345</residue_number>
    <molecular_weight>37924.0</molecular_weight>
    <theoretical_pi>5.71</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Hydroxyindole O-methyltransferase
MCSQEGEGYSLLKEYANGFMVSQVLFAACELGVFELLAEALEPLDSAAVSSHLGSSPQGT
ELLLNTCVSLKLLQADVRGGKAVYANTELASTYLVRGSPRSQRDMLLYAGRTAYVCWRHL
AEAVREGRNQYLKAFGIPSEELFSAIYRSEDERLQFMQGLQDVWRLEGATVLAAFDLSPF
PLICDLGGGSGALAKACVSLYPGCRAIVFDIPGVVQIAKRHFSASEDERISFHEGDFFKD
ALPEADLYILARVLHDWTDAKCSHLLQRVYRACRTGGGILVIESLLDTDGRGPLTTLLYS
LNMLVQTEGRERTPAEYRALLGPAGFRDVRCRRTGGTYDAVLARK</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAA30565.1</genbank_protein_id>
  <uniprot_id>P10950</uniprot_id>
  <uniprot_name>ASMT_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>J02671</genbank_gene_id>
  <genecard_id>ASMT</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
