| Identification |
|---|
| BMDB Protein ID
| BMDBP00414 |
| Secondary Accession Numbers
| None |
| Name
| Methionine synthase |
| Synonyms
|
Not Available
|
| Gene Name
| MTR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). |
| Pathways
|
- Amino-acid biosynthesis
- Betaine Metabolism
- L-methionine biosynthesis via de novo pathway
- L-methionine from L-homocysteine (MetH route): step 1/1
- Methionine Metabolism
|
| Reactions
|
| Homocysteine + 5-Methyltetrahydrofolic acid → L-Methionine + Tetrahydrofolic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| MTR |
| Gene Sequence
|
>3798 bp
ATGGCCCCCACGCTCCAGGACCTGACGCCATCTGCAGGGATGAAGAAGACCCTGCAAGAT
GAGATTGAAGCTATCCTGCAGGAGAGGATTATGGTGCTTGATGGAGGGATGGGGACCATG
ATCCAGCGGCACAAGCTGAGTGAAGAAGACTTCCGAGGACAAGAATTTAAAGATCATGCC
AGGCCCCTGAAAGGCAACAATGACATTTTAAGTATAACTCAGCCCAATGTCATTTACCAA
ATCCATAAGGAGTACCTCCTAGCTGGGGCAGATATCATTGAAACAAATACTTTCAGCAGC
ACTTCTATTGCCCAAGCTGACTATGGCCTGGAACACTTGGCCTACCGGATGAACATGTGC
TCTGCGGGAGTGGCCAGAAAAGCAGCCGAGGACATCTCTCTCCAGACAGGAATTAAGAGG
TATGTGGCAGGAGCTCTGGGTCCAACTAACAAGACACTCTCTGTGTCGCCATCTGTGGAA
AGACCAGATTACAGGAACATCACATTTGATGAACTTGTTGAAGCATACAAAGAGCAGGCC
AAAGGGCTTCTGGATGGTGGAGTGGATATCTTACTCATTGAAACTATTTTTGATACCGCC
AATGCCAAGGCAGCCTTGTTTGCAGTCCAAAAACTTTTTGAAGAGGAGTATGTTCCCCGG
CCTGTCTTTATTTCAGGGACAATTGTTGATAAAAGTGGGCGGACTCTCTCTGGCCAGACT
GGGGAGGCATTTGTCATCAGCGTGTCTCATGCAGACCCACTCTGCATTGGATTAAATTGT
GCTCTGGGTGCAGCTGAAATGAGACCTTTTATTGAAACAATTGGAAAATGTACAACAGCT
TATGTTCTCTGTTATCCCAATGCAGGTCTTCCCAATACCTTCGGTGACTATGATGAAACT
CCCCACGTGATGGCCATGCATTTAAAGGATTTTGCTGTTGATGGCTTGGTCAACATAGTT
GGCGGATGCTGTGGTACGACACCAGATCATATCAGAGAAATTGCTGAAGCTGTGAAAAAC
TGTAAGCCTAGAGTTCCACCTGCCACTGTTTTCGAAGGGCATATGCTACTGTCTGGTCTA
GAGCCCTTCAGGATTGGACCATACACCAACTTTGTTAACATTGGAGAGCGCTGTAACGTT
GCAGGATCCAGGAGATTTGCTAAGCTCATCATGGCAGGAAATTATGAAGAAGCACTGAGC
GTTGCCAAAATGCAGGTGGAAATGGGAGCCCAGGTGTTGGATATTAACATGGATGATGGC
ATGCTGGATGGTCCAAGTGCAATGACCAGATTCTGCAACTTCATTGCTTCCGAGCCTGAC
ATTGCCAAGGTGCCCTTGTGCATTGACTCTTCCAATTTTGCTGTGATTGAAGCCGGCTTA
AAGTGCTGCCAGGGGAAGTGCATTGTTAATAGCATCAGCTTGAAGGAGGGAGAGGATGAC
TTCTTGGAGAAGGCCAGAAAGATTAAGAAGTTTGGAGCTGCCGTGGTGGTTATGGCTTTT
GATGAAGAAGGACAGGCAACAGAAACAGATCCCAAAATCAGAGTGTGCACCCGGGCCTAC
CATCTCCTTTTGAAAAAACTGGGCTTCAATCCAAATGACATCATCTTTGACCCTAATATC
CTCACCATTGGTACTGGGATGGAAGAACATAACTTGTATGCTGTTAATTTTATCAATGCA
ACAAAAGTCATTAAAGAAACGCTGCCTGGAGCCAAAGTAAGCGGTGGTCTTTCCAACTTG
TCCTTCTCCTTCCGAGGAATGGAAGCCATTCGAGAGGCAATGCATGGGGTTTTCCTGTAC
CATGCGATCAAGTTTGGTATGGACATGGGAATAGTGAATGCTGGAAGCCTTCCTGTATAT
GATGACATCCACAAGGAGCTTCTCCAGCTCTGTGAGGACCTCATCTGGAACAGAGACCCT
GAGGCCACCGAGAAGCTCTTACACTACGCCCAGACTCAGGGCAAAGGAGGGAAGAAAGTC
ATCCAGACTGATGAGTGGAGGAATGGCCCTCTCGAAGAACGCCTTGAGTACGCTCTTGTG
AAGGGCATTGAAAAATATATTATTGAAGATACTGAGGAAGCCAGGTTAAACCAGGAAAAA
TATCCCCGACCTCTGAATATAATTGAAGGGCCGCTGATGAATGGCATGAAAATTGTTGGT
GATCTTTTTGGAGCTGGAAAAATGTTTCTACCTCAGGTTATAAAGTCAGCTCGGGTCATG
AAGAAGGCCGTGGGTCACCTTATTCCCTTCATGGAAAAAGAGAGAGAAGAAACCAAAGTG
CTTACTGGCAAAATAGAAGATGAGGACCCTTACCAAGGCACCATCGTGCTGGCTACTGTT
AAAGGTGACGTACACGACATAGGCAAGAACATAGTTGGAGTGGTTCTTGGCTGCAATAAT
TTCAGAGTTATTGATTTAGGAGTCATGACTCCATGTGACAAGATACTGAAGGCTGCTCTA
GACCACAAAGCAGATATAATTGGCCTGTCAGGACTCATCACTCCTTCCCTGGATGAAATG
ATTTTTGTCGCTAAGGAAATGGAGAGACTAGCTATAAAGATCCCATTGTTGATCGGAGGA
GCTACCACTTCCAGAACCCACACAGCAGTTAAAATAGCCCCAAGATACAGTGCGCCCGTG
ATCCACGTCCTGGATGCATCCAAGAGCGTGGTGGTGTGTTCTCAACTGTTAGATGAGAAT
CTAAAAGATGAGTACTTTGAGGAGATCCTGGAAGAATATGAAGATATTAGACAGGACCAT
TATGAATCTCTCAAGGAGAGAAGATACTTAACCTTAAGGCAAGCTAGAGAAAATGGTTTC
CATATTGACTGGCTGTCAGAGCCTCCTCCAGTGAAGCCCACGTTCCTCGGGACTCGGGTC
TTTGAAGACTACGACCTGCAGAAGCTGGTGGACTACATTGATTGGAAGCCTTTCTTCGAC
GTCTGGCAGCTCCGGGGCAAATACCCGAACCGAGGCTTTCCCAAGATATTTGACGACAAA
ACTGTAGGTGAAGAGGCCAAAAAGGTCTATGATGATGCCCAAAATATGCTGCAGGCACTG
ATCAGTCAGAAGAAGCTCCAGGCCAGGGGTGTGGTTGGGTTCTGGCCAGCACAGAGCATT
CAGGATGATATCCACCTGTACGCGGAAGGCGCAGTGCCACAGGCCTCGGAGCCCATAGCC
ACCTTCTACGGGCTCAGGCAGCAGGCCGAGAAGGACTCTGCCAGCTCGGACCCCTACCTC
TGCCTCTCGGACTTCATCGCCCCTCTGCACTCAGGTATCCCCGACTACCTGGGCCTGTTC
GCCGTTGCCTGCTTTGGGGTGGAGGAGCTGAGCAAGGCCTACGAGGAGGAGTGTGATGAC
TACAGCAGCATCATGGTCAAGGCGCTGGGGGACCGGCTGGCCGAGGCCTTCGCTGAGGAG
CTGCACGAGCGGGCCCGCAGGGAGCTGTGGGGTTACTGTAGTGGTGAGCAGCTGGCTGTG
GCTGACCTGCGGAGACTGCGCTACGAGGGCATCCGGCCGGCGCCCGGCTATCCCAGCCAG
CCTGACCACACTGAGAAGCTGACCGTGTGGAGGCTGGCGGACGTGGAGCAGCGCACAGGC
ATTAGGTTAACAGAATCGCTGGCCATGGCACCTGCTTCAGCAGTATCTGGCCTTTACTTC
TCCAACTTGAAGTCCAAGTATTTTGCCGTGGGGAAAATTTCCAAGGATCAGATTGAGGAT
TATGCTTCGAGGAAGAACATGTCTGTGGCCGAGGTTGAGAAATGGCTTGGACCCATTTTG
GGATATGATACAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1265 |
| Molecular Weight
| 140478.0 |
| Theoretical pI
| 4.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionine synthase
MAPTLQDLTPSAGMKKTLQDEIEAILQERIMVLDGGMGTMIQRHKLSEEDFRGQEFKDHA
RPLKGNNDILSITQPNVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMC
SAGVARKAAEDISLQTGIKRYVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYKEQA
KGLLDGGVDILLIETIFDTANAKAALFAVQKLFEEEYVPRPVFISGTIVDKSGRTLSGQT
GEAFVISVSHADPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDET
PHVMAMHLKDFAVDGLVNIVGGCCGTTPDHIREIAEAVKNCKPRVPPATVFEGHMLLSGL
EPFRIGPYTNFVNIGERCNVAGSRRFAKLIMAGNYEEALSVAKMQVEMGAQVLDINMDDG
MLDGPSAMTRFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDD
FLEKARKIKKFGAAVVVMAFDEEGQATETDPKIRVCTRAYHLLLKKLGFNPNDIIFDPNI
LTIGTGMEEHNLYAVNFINATKVIKETLPGAKVSGGLSNLSFSFRGMEAIREAMHGVFLY
HAIKFGMDMGIVNAGSLPVYDDIHKELLQLCEDLIWNRDPEATEKLLHYAQTQGKGGKKV
IQTDEWRNGPLEERLEYALVKGIEKYIIEDTEEARLNQEKYPRPLNIIEGPLMNGMKIVG
DLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETKVLTGKIEDEDPYQGTIVLATV
KGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEM
IFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDEN
LKDEYFEEILEEYEDIRQDHYESLKERRYLTLRQARENGFHIDWLSEPPPVKPTFLGTRV
FEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFDDKTVGEEAKKVYDDAQNMLQAL
ISQKKLQARGVVGFWPAQSIQDDIHLYAEGAVPQASEPIATFYGLRQQAEKDSASSDPYL
CLSDFIAPLHSGIPDYLGLFAVACFGVEELSKAYEEECDDYSSIMVKALGDRLAEAFAEE
LHERARRELWGYCSGEQLAVADLRRLRYEGIRPAPGYPSQPDHTEKLTVWRLADVEQRTG
IRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQIEDYASRKNMSVAEVEKWLGPIL
GYDTD
|
| External Links |
|---|
| GenBank ID Protein
| AAY86762.1 |
| UniProtKB/Swiss-Prot ID
| Q4JIJ3 |
| UniProtKB/Swiss-Prot Entry Name
| METH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ084519 |
| GeneCard ID
| MTR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
