1.0 2018-05-07 22:22:18 UTC 2020-05-20 21:02:39 UTC BMDBP00418 Enzyme EZH1 Involved in DNA binding Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. BMDB0000182 L-Lysine BMDB0000939 S-Adenosylhomocysteine BMDB0001185 S-Adenosylmethionine 19 >2124 bp ATGGATATACCAAATCCCCCGACGTCCAAATGTATCACTTACTGGAAGAGGAAAGTTAAG TCTGAATACATGCGACTTCGGCAGCTTAAACGGCTTCAGGCGAATATGGGTGCAAAGGCT CTCTATGTAGCAAATTTTGCAAAAGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTTAATGAAGCCTGTGAGTGGGCATCCTTTTCTC AAAAAGTGTACCATAGAGAGCATTTTCCCGGGATTTGCAAGCCAGCACATGTTAATGAGG TCTCTGAACACAGTTGCCTTGGTTCCCATCATGTACTCGTGGTCCCCTCTCCAGCAGAAC TTCATGGTGGAAGATGAGACAGTTTTGTGCAATATCCCCTACATGGGAGATGAGGTGAAA GAGGAAGATGAGACTTTCATTGAGGAGCTGATCAATAACTACGATGGCAAAGTCCACGGT GAAGAAGAGATGATTCCTGGCTCTGTCCTGATCAGTGATGCTGTTTTCCTGGAGTTGGTA GATGCTCTGAATCAATACTCAGATGAAGATGAAGAAGGGCACAACGACACCTCAGATGGA AAGCAAGATGACAGCAAAGAGGATCTGCCAGTAACAAGAAAGAGGAAACGACATGCTATT GAAGGCAGCAAAAAGAGTTCCAAGAAACAATTCCCAAACGACATGATCTTCAGTGCGATC GCCTCGATGTTCCCTGAGAACGGTGTCCCAGACGACATGAAGGAGAGGTACCGAGAGCTC ACAGAGATGTCAGACCCCAATGCGCTCCCCCCGCAGTGCACACCCAACATCGACGGCCCC AACGCCAAGTCTGTGCAGCGGGAACAGTCTCTGCACTCCTTCCACACACTCTTCTGCCGG CGCTGCTTCAAATACGACTGCTTCCTTCACCCTTTCCATGCCACCCCTAATGTGTATAAA CGCAAGAACAAAGAAATCAAGATTGAGCCAGAACCGTGTGGCACAGACTGCTTCCTTCTG CTGGAAGGAGCAAAGGAGTACGCCATGCTGCACAACCCTCGCTCCAAGTGCTCTGGGCGT CGCCGGCGAAGGCACCACGTGGTCAATGCCTCCTGCTCCAACACTTCAGCCTCTGCTGTG GCTGAGACCAAAGAAGGGGACAGCGACAGGGACACTGGCAATGACTGGGCCTCCAGTTCT TCAGAGGCAAACTCACGCTGTCAGACGCCCACGAAACAGAAGGCGAGTCCAGCCCCACCT CAGCTCTGTGTCGTGGAAGCACCCTCAGAACCTGTGGAGTGGACTGGGGCTGAAGAATCT CTTTTTCGAGTCTTTCATGGCACCTACTTCAACAACTTCTGTTCAATAGCCAGACTTCTG GGGACTAAGACATGCAAGCAGGTCTTCCAGTTTGCAGTCAAAGAGTCACTTATCCTGAAG CTGCCCACAGATGAGCTTATGAACCCCTCGCAGAAGAAGAAGAGAAAGCACAGGTTGTGG GCTGCACACTGCCGGAAAATTCAGCTGAAGAAAGATAACTCCTCCACCCAGGTGTACAAC TACCAGCCCTGCGACCACCCGGACCGCCCCTGTGACAGCACGTGCCCCTGCATCATGACT CAGAATTTCTGTGAGAAGTTCTGCCAGTGCAACCCCGACTGTCAGAATCGCTTTCCCGGC TGTCGCTGTAAGACCCAGTGCAATACCAAGCAGTGCCCGTGCTACCTGGCGGTGCGCGAG TGTGACCCTGACCTGTGCCTCACCTGTGGGGCCTCGGAGCACTGGGACTGCAAGGTGGTT TCCTGTAAGAACTGCAGCATTCAACGTGGCCTCAAAAAGCACCTGCTGCTGGCCCCCTCA GATGTGGCCGGATGGGGCACCTTCATTAAGGAGTCTGTGCAGAAGAATGAATTCATTTCT GAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCCGATCGACGAGGGAAGGTCTATGAC AAGTACATGTCCAGCTTCCTCTTCAACCTCAATAACGATTTTGTAGTGGATGCTACCCGG AAAGGAAACAAAATTCGATTTGCAAACCATTCGGTGAACCCCAACTGTTATGCCAAAGCC AAAATAACAGATCTAAAAGCATAG 747 85285.0 7.77 None >Histone-lysine N-methyltransferase EZH1 MDIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW KKLRVQPVQLMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV DALNQYSDEDEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGSKKSSKKQFPNDMIFSAI ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR RRRRHHVVNASCSNTSASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG EELFFDYRYSQADALKYVGIERETDVL AAI51627.1 A7E2Z2 EZH1_BOVIN BC151626 EZH1