| Identification |
|---|
| BMDB Protein ID
| BMDBP00419 |
| Secondary Accession Numbers
| None |
| Name
| Histone-lysine N-methyltransferase KMT5B |
| Synonyms
|
Not Available
|
| Gene Name
| KMT5B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone-lysine N-methyltransferase activity |
| Specific Function
| Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| KMT5B |
| Gene Sequence
|
>1182 bp
ATGAAGTGGTTGGGAGAATCCAAGAACATGGTGGTGAATGGCAGGAGACATGGAGGCAAG
TTGTCTAATGACCATCAGCAGAATCAATCAAAGTTACAGCACTCGGGAAAGGACAACGTG
AAGGCTGGCAGAAACGCAGGCGAGAGGAGGTCGAGCAGATGTAATGGGAACTCAGGCTTT
GAGGGACAGAGTCGATATGTACCATCTTCTGGAATGTCTGCCAAGGAACTCTGTGAAAAT
GATGACCTAGCGACCAGTTTGGTTCTTGATCCCTATTTAGGTTTTCAAACACACAAAATG
AATACTAGCGCCTTTCCTCCGAGGAGCTCAAGGCATTTTTCAAAATCTGACAGTTTTTCT
CACAACAACCCTGTAAGATTTCGGCCTATTAAAGGAAGGCAGGAAGAACTCAAAGAAGTA
ATTGAACGTTTTAAGAAAGATGAGCACTTGGAGAAAGCCTTCAAATGTCTGACTTCAGGA
GAATGGGCACGGCACTATTTTCTCAACAAGAACAAAATGCAGGAGAAATTATTCAAGGAA
CATGTATTTATTTATTTGCGAATGTTTGCAACTGACAGTGGATTTGAAATATTGCCTTGT
AATAGATACTCTTCAGAACAAAATGGAGCCAAAATAGTTGCAACGAAAGAGTGGAAACGA
AATGACAAAATAGAATTACTGGTGGGTTGTATTGCCGAACTTTCAGAAATTGAGGAGAAC
ATGCTGCTTAGACATGGAGAAAACGACTTCAGTGTCATGTATTCCACAAGGAAAAACTGT
GCTCAGCTCTGGCTTGGTCCTGCTGCATTTATAAACCATGATTGCAGACCTAACTGTAAG
TTTGTGTCAACTGGTCGAGATACAGCATGTGTGAAGGCCCTAAGAGATATTGAACCTGGA
GAAGAAATTTCTTGTTATTATGGAGATGGGTTTTTTGGAGAAAACAATGAGTTCTGCGAG
TGTTACACTTGTGAAAGACGGGGAACTGGTGCTTTTAAATCCAGAGTGGGACTGCCTGCG
CCTGCTCCTGTTATCAATAGCAAATACGGACTCAGAGAAACAGATAAACGTTTAAATAGG
CTTAAAAAGTTAGGTGACAGCAGCAAAAACTCAGACAGTCAGTCTGTCAGCTCCAACACT
GACGCAGACACCACTCAGGGAAGAAACGACGCAAGTAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 393 |
| Molecular Weight
| 44552.0 |
| Theoretical pI
| 8.91 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SUV420H1
MKWLGESKNMVVNGRRHGGKLSNDHQQNQSKLQHSGKDNVKAGRNAGERRSSRCNGNSGF
EGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMNTSAFPPRSSRHFSKSDSFS
HNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTSGEWARHYFLNKNKMQEKLFKE
HVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEEN
MLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPG
EEISCYYGDGFFGENNEFCECYTCERRGTGAFKSRVGLPAPAPVINSKYGLRETDKRLNR
LKKLGDSSKNSDSQSVSSNTDADTTQGRNDASK
|
| External Links |
|---|
| GenBank ID Protein
| AAI14080.1 |
| UniProtKB/Swiss-Prot ID
| Q29RP8 |
| UniProtKB/Swiss-Prot Entry Name
| KMT5B_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114079 |
| GeneCard ID
| KMT5B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
