| Identification |
|---|
| BMDB Protein ID
| BMDBP00428 |
| Secondary Accession Numbers
| None |
| Name
| Isovaleryl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| IVD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA. |
| Pathways
|
- (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3
- Amino-acid degradation
- Fatty Acid Metabolism
- L-leucine degradation
- Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids
- Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| Isovaleryl-CoA + electron-transfer flavoprotein → 3-Methylcrotonyl-CoA + Reduced electron-transfer flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| IVD |
| Gene Sequence
|
>1281 bp
ATGGCGACTGCGGCTTGGTTACTGGGTCGGCGCGTGGCGAGCTGGAGGATGCGACCGCCG
CTGCAGTCTCTTGCTGGCCTGATTACCCAGCGGACCAACTCGCTGTTGCCTGTGGACGAT
GCAGTCAATGGGCTGAACGAGGAGCAGAAGCAGCTTCGTCAGACCGTGGCTAAATTCCTT
CAGGAGCATCTAGCCCCCCAGGCCCAGGAGATCGACCAAAGTAATGAGTTCAAGAACCTG
CGAGAGTTTTGGAAGCAGCTGGGGAACCTAGGAGTCTTGGGCATCACAGCCCCTGTTCAG
TACGGTGGTTCTGGCCTGGGCTTCCTGGAAAACGTGCTGGTGATGGAGGAGATATCCCGA
GTGTCTGGAGCAGTGGGGCTCAGTTATGGAGCCCACTCCAACCTCTGTATCAACCAAATT
GTGCGGAATGGAAACGAGACCCAGAAGGAGAAGTACCTCCCCAAGCTGATAAGTGGTGAA
TACATCGGAGCCCTGGCCATGAGTGAGCCCAATGCTGGCTCTGATGTTGTCTCCATGAAG
CTGAAAGCAGAAAAGAAAGGAGATCACTATGTCCTGAATGGCAACAAGTTCTGGATCACC
AATGGTCCTGATGCAGATGTCCTTGTTGTCTATGCCAAGACTGATGTGACTGCTGTGCCA
GCTTCTCGGGGCATCACAGCCTTCATTGTGGAGAAGGGGATGCCGGGCTTCAGCACCTCC
AAGAAGCTGGACAAGCTAGGGATGAGGGGCTCCAATACCTGTGAGCTGGTCTTCGAAGAC
TGCGAGGTTCCTGCTGCCAACATCCTGGGTCACCTAGGTAAGGGCGTCTATGTGCTGATG
AGTGGGCTGGACCTGGAGCGGCTGGTGCTGGCCGGTGGGCCCCTTGGGATCATGCAGGCC
GTCCTCGACCACACTATTCCCTACCTGCACATGAGGGAGGCCTTTGGCCAGAAGATTGGC
CACTTCCAGTTGATGCAGGGGAAGATGGCAGATATGTACACCCGTCTCATGGCCTGTCGT
CAGTACGTCTACAACGTTGCCAAGGCCTGTGATGAGGGCCACTGCACTACCAAGGACTGT
GCAGGGGTGATTCTTTACTCGGCCGAGTGTGCCACACAGGTAGCCCTGGACGGCATCCAG
TGTTTGGGTGGCAATGGCTACATCAACGACTTTCCCATGGGCCGCTTCCTGAGAGATGCC
AAGCTGTATGAGATCGGGGCTGGGACCAGCGAAGTGAGGCGGCTCGTCATCGGCAGAGCT
TTCAATGCAGACTTCCACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 426 |
| Molecular Weight
| 46498.0 |
| Theoretical pI
| 7.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isovaleryl-CoA dehydrogenase, mitochondrial
MATAAWLLGRRVASWRMRPPLQSLAGLITQRTNSLLPVDDAVNGLNEEQKQLRQTVAKFL
QEHLAPQAQEIDQSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGFLENVLVMEEISR
VSGAVGLSYGAHSNLCINQIVRNGNETQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMK
LKAEKKGDHYVLNGNKFWITNGPDADVLVVYAKTDVTAVPASRGITAFIVEKGMPGFSTS
KKLDKLGMRGSNTCELVFEDCEVPAANILGHLGKGVYVLMSGLDLERLVLAGGPLGIMQA
VLDHTIPYLHMREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTTKDC
AGVILYSAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRA
FNADFH
|
| External Links |
|---|
| GenBank ID Protein
| AAI02837.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZI8 |
| UniProtKB/Swiss-Prot Entry Name
| IVD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102836 |
| GeneCard ID
| IVD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
