| Identification |
|---|
| BMDB Protein ID
| BMDBP00429 |
| Secondary Accession Numbers
| None |
| Name
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
| Synonyms
|
Not Available
|
| Gene Name
| PDE6C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 3',5'-cyclic-GMP phosphodiesterase activity |
| Specific Function
| As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| PDE6C |
| Gene Sequence
|
>2568 bp
ATGGGTGAGATCAGCCAAGAGACGGTGGAGAAATACCTGGAGGCCAACCCTCAGTTCGCC
AAGGAGTATTTCAACAGGAAGTTGCAGGTGGAGGTGCCGAGCGGCGGGGCACAGGCACCG
GCCAGCGCCTCCTTCCCCGGCCGGACGCTGGCGGAGGAGGCGGCCCTGTACCTGGAGCTG
CTGGAGGTCTTGCTGGAGGAGGCGGGCAGCGTGGAGCTGGCGGCACACAGGGCCCTGCAG
AGGCTGGCGCAGCTGCTGCAGGCAGACCGCTGCAGCATGTTCCTGTGTCGGGCCCGCAAC
GGCACGCCGGAGGTGGCCTCCAAGCTGCTCGATGTCACCCCCACTTCCAAGTTTGAGGAC
AACCTGGTGGTCCCCGACAGAGAAGCTGTGTTTCCGTTGGACGTTGGGATAGTGGGGTGG
GTTGCTCACACGAAGAAAACCTTTAATGTTCCAGATGTGAAAAAGAACAGCCATTTTTCT
GACTTCATGGACAAACAAACCGGGTATGTCACCAGGAACCTGCTGGCAACCCCCATCGTG
ATGGGCAAGGAGGTTCTTGCTGTGTTTATGGCAGTTAACAAAGTAGACGCATCCGAATTT
TCCAAACAGGATGAAGAGGTCTTTTCCAAATACCTCAGCTTTGTTTCTATCATCCTAAAG
CTTCACCACACCAACTACCTGTACAATATTGAATCCCGAAGAAGTCAGATTCTTATGTGG
TCAGCCAACAAAGTATTTGAAGAGCTCACAGATGTTGAGCGACAGTTTCACAAAGCACTC
TACACTGTCAGGACATACCTGAACTGCGAACGATACTCCATTGGGCTGCTGGACATGACC
AAGGAGAAGGAATTCTATGATGAGTGGCCAGTCAAGCTTGGAGAAGTCGAGCCTTACAAA
GGTCCAAAGACACCAGATGGCAGAGAAGTCATCTTTTATAAAATCATCGATTACATTTTA
CATGGAAAAGAAGAGATCAAAGTCATTCCGACACCTCCCATGGACCACTGGACTCTCATT
AGTGGGTTGCCAACATATGTTGCTGAAAATGGATTTATCTGCAACATGCTGAACGCCCCG
GCGGATGAATACTTCACGTTTCAGAAAGGACCTGTAGATGAAACTGGCTGGGTCATTAAA
AATGTCTTGTCCCTGCCTATTGTCAACAAAAAGGAAGACATCGTGGGCGTAGCTACATTT
TACAACAGGAAGGATGGAAAGCCTTTTGATGAATATGATGAGCACATCGCTGAGACTCTC
ACACAGTTTCTTGGATGGTCTCTCTTAAATACTGACACCTATGAGAAAATGAATAAGCTG
GAGAACAGAAAGGACATAGCCCAGGAAATGCTCATGAACCACACCAAGGCTACACCTGAT
GAGATCAAGTCTATTTTGAAATTTAAAGAGAAGTTAAATATAGATGTAATTGAAGACTGT
GAAGAAAAACAGCTTGTCACAATTTTGAAGGAGGACCTGCCAGACCCACGGACTGCAGAC
CTGTATGAATTCCGCTTCAGGCACTTGCCCATCACAGAGCACGAACTGATTAAGTGTGGA
CTTCGGCTGTTTTTTGAAATAAACGTGGTGGAGAAATTCAAAGTACCTGTAGAGGTTCTC
ACCAGATGGATGTACACGGTGAGGAAGGGGTACCGGGCCGTCACATACCACAACTGGCGA
CACGGGTTTAACGTGGGGCAGACCATGTTCACTTTGCTGATGACAGGAAGACTGAAGAAA
TACTACACAGACCTTGAAGCCTTTGCCATGCTTGCTGCTGCCTTCTGCCACGACATTGAC
CACAGAGGCACCAATAATTTGTATCAGATGAAGTCCACATCTCCGCTAGCAAGGCTTCAC
GGCTCTTCCATCTTGGAGAGGCACCACCTGGAGTACAGTAAGACGCTCCTGCAGGATGAG
AGTTTAAACATATTCCAGAACCTAAATAAACGCCAGTATGAAACAGTTATTCATTTGTTT
GAAGTTGCGATAATAGCGACTGACCTGGCTTTATATTTCAAGAAGAGAACCATGTTTCAA
AAAATTGTTGATGCCTGTGAAAAAATGGAAACTGAAGAAGAGGCCATCAAATATGTAACC
ATTGATCCAACCAAAAAAGAGATTATCATGGCAATGATGATGACTGCGTGTGATCTGTCA
GCTATAACCAAGCCCTGGGAGGTGCAAAGTCAGGTAGCACTCCTGGTTGCAAATGAATTT
TGGGAACAAGGAGATCTGGAGAGAACAGTGCTGCAGCAACAACCCATTCCTATGATGGAC
AGAAACAAAAAAGATGAACTACCTAAACTTCAAGTTGGATTTATTGACTTTGTCTGTACT
TTTGTATATAAGGAGTTTTCACGGTTTCACAAAGAAATCACACCTATGCTGAATGGTCTT
CAAAACAACAGAGTGGAATGGAAATCCCTAGCTGATGAGTATGATGAAAAGATGAAGGTA
ATTGAAGAGATGAAAAAGCAGGAAGAAGGAAATACGACAGAAAAAGCTGTAGAAGATTCA
GGAGGTGGTGGTGATGACAAGAAATCCAAAACATGTCTAATGTTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 855 |
| Molecular Weight
| 98798.0 |
| Theoretical pI
| 5.53 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
MGEISQETVEKYLEANPQFAKEYFNRKLQVEVPSGGAQAPASASFPGRTLAEEAALYLEL
LEVLLEEAGSVELAAHRALQRLAQLLQADRCSMFLCRARNGTPEVASKLLDVTPTSKFED
NLVVPDREAVFPLDVGIVGWVAHTKKTFNVPDVKKNSHFSDFMDKQTGYVTRNLLATPIV
MGKEVLAVFMAVNKVDASEFSKQDEEVFSKYLSFVSIILKLHHTNYLYNIESRRSQILMW
SANKVFEELTDVERQFHKALYTVRTYLNCERYSIGLLDMTKEKEFYDEWPVKLGEVEPYK
GPKTPDGREVIFYKIIDYILHGKEEIKVIPTPPMDHWTLISGLPTYVAENGFICNMLNAP
ADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEYDEHIAETL
TQFLGWSLLNTDTYEKMNKLENRKDIAQEMLMNHTKATPDEIKSILKFKEKLNIDVIEDC
EEKQLVTILKEDLPDPRTADLYEFRFRHLPITEHELIKCGLRLFFEINVVEKFKVPVEVL
TRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDID
HRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQYETVIHLF
EVAIIATDLALYFKKRTMFQKIVDACEKMETEEEAIKYVTIDPTKKEIIMAMMMTACDLS
AITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPKLQVGFIDFVCT
FVYKEFSRFHKEITPMLNGLQNNRVEWKSLADEYDEKMKVIEEMKKQEEGNTTEKAVEDS
GGGGDDKKSKTCLML
|
| External Links |
|---|
| GenBank ID Protein
| AAA30687.1 |
| UniProtKB/Swiss-Prot ID
| P16586 |
| UniProtKB/Swiss-Prot Entry Name
| PDE6C_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M37838 |
| GeneCard ID
| PDE6C |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
