1.0 2018-05-07 22:22:22 UTC 2020-05-20 21:07:41 UTC BMDBP00434 Enzyme PDE5A Involved in 3',5'-cyclic-GMP phosphodiesterase activity Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity). 3',5'-cyclic GMP degradation GMP from 3',5'-cyclic GMP: step 1/1 Purine Metabolism SMP0087239 BMDB0000547 Magnesium BMDB0000608 Cobalt BMDB0001314 Cyclic GMP BMDB0001333 Manganese BMDB0001397 Guanosine monophosphate BMDB0011629 Guanosine 2',3'-cyclic phosphate BMDB0002111 Water 6 >2598 bp ATGGAGAGGGCCGGCCCCGGCTCCGCGCGGCCGCAACAGCAATGGGACCAGGACTCGGTC GAAGCGTGGCTGGACGATCACTGGGACTTTACCTTCTCTTACTTTGTTAGGAAAGGCACC AGAGAAATGGTCAACGCATGGTTTGCTGAGAGAGTTCACACCATTCCTGTGTGCAAGGAA GGAATCAAGGGCCACACGGAATCCTGCTCTTGCCCCTTGCAGCCAAGTCCCCGTGCAGAG AGCAGTGTCCCTGGAACACCAACCAGGAAGATCTCTGCCTCTGAATTCGATCGGCCGCTT AGACCCATCGTTATCAAGGATTCTGAGGGAACTGTGAGCTTCCTCTCTGACTCAGACAAG AAGGAACAGATGCCTCTAACCTCCCCACGGTTTGATAATGATGAAGGGGACCAGTGCTCG AGACTCTTGGAATTAGTGAAAGATATTTCTAGTCACTTGGATGTCACAGCCTTATGTCAC AAAATTTTCTTGCACATCCATGGACTCATCTCCGCCGACCGCTACTCCTTATTCCTCGTC TGTGAGGACAGCTCCAACGACAAGTTTCTTATCAGCCGCCTCTTTGATGTTGCAGAAGGT TCAACACTGGAAGAAGCTTCAAACAACTGCATCCGCTTAGAGTGGAACAAAGGCATCGTG GGACACGTGGCCGCTTTTGGCGAGCCCTTGAACATCAAAGACGCCTATGAGGATCCTCGA TTCAATGCAGAAGTTGACCAAATTACAGGCTACAAGACACAAAGTATTCTTTGTATGCCA ATTAAGAATCATAGGGAAGAGGTTGTTGGTGTAGCCCAGGCCATCAACAAGAAATCAGGA AATGGTGGGACATTCACTGAAAAAGACGAAAAGGACTTTGCTGCTTACTTGGCATTTTGT GGAATTGTTCTTCATAATGCTCAACTCTATGAGACTTCACTGCTGGAGAACAAGAGAAAT CAGGTGCTGCTTGACCTTGCTAGCTTAATTTTTGAAGAACAACAATCATTAGAAGTAATT CTAAAGAAAATAGCTGCCACTATTATCTCTTTCATGCAGGTGCAGAAATGCACCATTTTC ATAGTGGATGAAGATTGCTCCGATTCTTTTTCTAGTGTGTTTCACATGGAGTGTGAGGAA TTAGAAAAATCGTCAGATACTTTAACACGGGAACGTGATGCAAACAGAATCAATTACATG TATGCTCAGTATGTCAAAAATACCATGGAACCACTTAATATCCCAGACGTCAGTAAGGAC AAAAGATTTCCCTGGACAAATGAAAACATGGGAAATATAAACCAGCAGTGCATTAGAAGT TTGCTTTGTACACCTATAAAAAATGGAAAGAAGAACAAAGTGATAGGGGTTTGCCAACTT GTTAATAAGATGGAGGAAACCACTGGCAAAGTTAAGGCTTTCAACCGCAACGATGAACAG TTTCTGGAAGCTTTCGTCATCTTTTGTGGCTTGGGGATCCAGAACACACAGATGTACGAA GCAGTGGAGAGAGCCATGGCCAAGCAAATGGTCACGTTAGAGGTTCTGTCTTATCATGCT TCAGCTGCAGAGGAAGAAACCAGAGAGCTGCAGTCCTTAGCGGCTGCTGTGGTACCATCT GCCCAGACCCTTAAAATCACTGACTTCAGCTTCAGCGACTTTGAGCTGTCTGACCTGGAA ACAGCACTGTGCACAATCCGGATGTTCACTGACCTCAACCTTGTGCAGAACTTCCAGATG AAACATGAGGTCCTTTGCAAGTGGATTTTAAGTGTGAAGAAGAACTATCGGAAGAACGTC GCCTATCATAATTGGAGACATGCCTTTAATACAGCTCAGTGCATGTTTGCGGCACTAAAA GCAGGCAAAATTCAGAAGAGGCTGACGGACCTGGAGATACTTGCACTGCTGATTGCTGCC TTAAGCCATGATCTGGATCACCGTGGTGTCAATAACTCATACATACAGCGAAGTGAACAC CCACTTGCTCAGCTCTACTGCCATTCAATCATGGAGCATCATCATTTTGATCAGTGCCTG ATGATCCTTAATAGTCCTGGCAATCAGATTCTCAGTGGCCTCTCCATTGAAGAGTATAAG ACCACCCTGAAGATCATCAAGCAAGCTATTTTAGCCACAGACCTAGCACTGTACATAAAG AGACGAGGAGAATTTTTTGAACTTATAATGAAAAATCAATTCAATTTGGAAGATCCTCAT CAAAAGGAGTTGTTTTTAGCGATGCTGATGACAGCTTGTGATCTTTCTGCAATTACAAAA CCCTGGCCTATTCAACAACGGATAGCAGAACTTGTTGCCACTGAATTTTTTGACCAAGGA GATAGAGAGAGGAAAGAACTCAACATAGAGCCCGCTGATCTAATGAACCGGGAGAAGAAA AACAAAATCCCAAGTATGCAAGTTGGATTCATAGATGCCATCTGCTTGCAACTGTATGAG GCCTTGACCCATGTGTCGGAGGACTGTTTCCCTTTGCTGGACGGCTGCAGAAAGAACAGG CAGAAATGGCAGGCTCTTGCAGAACAGCAGGAGAAGACACTGATCAATGGTGAAAGCAGC CAGACCAAGCGGAACTGA 865 98627.0 5.8 None >cGMP-specific 3',5'-cyclic phosphodiesterase MERAGPGSARPQQQWDQDSVEAWLDDHWDFTFSYFVRKGTREMVNAWFAERVHTIPVCKE GIKGHTESCSCPLQPSPRAESSVPGTPTRKISASEFDRPLRPIVIKDSEGTVSFLSDSDK KEQMPLTSPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV CEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF IVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYMYAQYVKNTMEPLNIPDVSKD KRFPWTNENMGNINQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEETTGKVKAFNRNDEQ FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPS AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCKWILSVKKNYRKNV AYHNWRHAFNTAQCMFAALKAGKIQKRLTDLEILALLIAALSHDLDHRGVNNSYIQRSEH PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIK RRGEFFELIMKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQG DRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNR QKWQALAEQQEKTLINGESSQTKRN AAB00990.1 Q28156 PDE5A_BOVIN 1FL4 3JAB 3JBQ L16545 PDE5A