| Identification |
|---|
| BMDB Protein ID
| BMDBP00450 |
| Secondary Accession Numbers
| None |
| Name
| Endonuclease G, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ENDOG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| ENDOG |
| Gene Sequence
|
>900 bp
ATGCAGTTGCTTCGGGCCGGCTTGACTCTGGCCCTGGGCGCAGGGCTGGGTGCAGCTGCC
GAGAGCTGGTGGCGACAGCGGGCGGACGCGCGGGCGACGCCGGGGCTGCTGAGCCGGCTG
CCGGTGCTGCCAGTGGCGGCGGCGGCGGGGCTTCCCGCGGTGCCAGGGGCTCCCGCGGGT
GGCGGCCCGGGCGAGTTAGCCAAGTATGGGCTGCCCGGGGTGGCGCAACTCAAGAGCCGC
GCGTCGTACGTGCTGTGTTACGACCCGCGCACCCGCGGCGCGCTCTGGGTGGTCGAGCAG
CTGCGGCCCGAGGGGCTCCGCGGCGACGGCAACCGCAGCTCCTGCGACTTCCACGAGGAC
GACTCGGTGCATGCGTACCACCGCGCCACCAACGCCGATTACCGCGGCAGCGGCTTCGAC
CGCGGCCACCTCGCTGCCGCGGCCAACCACCGCTGGAGCCAGAAGGCAATGGACGACACC
TTCTACCTGAGCAACGTCGCGCCCCAGGTGCCACACCTCAACCAAAATGCCTGGAACAAC
CTGGAAAAGTACAGCCGCAGTCTGACCCGCACCTACCAAAATGTCTATGTCTGCACCGGG
CCACTCTTCCTGCCCAGGACGGAGGCTGATGGGAAGTCCTACGTGAAGTACCAAGTCATT
GGCAAGAACCACGTGGCGGTGCCCACCCACTTCTTCAAGGTGCTGATCCTGGAGGCGGCA
GGTGGGCAGATAGAACTCCGCTCCTATGTGATGCCCAATGCGCCGGTGGATGAGGCAATC
CCGCTGGAGCACTTCCTGGTGCCCATTGAGAGCATTGAGCGGGCCTCCGGGCTGCTCTTT
GTGCCAAACATCCTGGCACGGGCGGGCAGCCTGAAGGCCATCACTGCTGGCAGCAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 299 |
| Molecular Weight
| 32262.0 |
| Theoretical pI
| 9.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Endonuclease G, mitochondrial
MQLLRAGLTLALGAGLGAAAESWWRQRADARATPGLLSRLPVLPVAAAAGLPAVPGAPAG
GGPGELAKYGLPGVAQLKSRASYVLCYDPRTRGALWVVEQLRPEGLRGDGNRSSCDFHED
DSVHAYHRATNADYRGSGFDRGHLAAAANHRWSQKAMDDTFYLSNVAPQVPHLNQNAWNN
LEKYSRSLTRTYQNVYVCTGPLFLPRTEADGKSYVKYQVIGKNHVAVPTHFFKVLILEAA
GGQIELRSYVMPNAPVDEAIPLEHFLVPIESIERASGLLFVPNILARAGSLKAITAGSK
|
| External Links |
|---|
| GenBank ID Protein
| CAA51320.1 |
| UniProtKB/Swiss-Prot ID
| P38447 |
| UniProtKB/Swiss-Prot Entry Name
| NUCG_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X72802 |
| GeneCard ID
| ENDOG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
