| Identification |
|---|
| BMDB Protein ID
| BMDBP00456 |
| Secondary Accession Numbers
| |
| Name
| Inositol monophosphatase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| IMPA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate. |
| Pathways
|
- Myo-inositol biosynthesis
- Myo-inositol from D-glucose 6-phosphate: step 2/2
- Polyol metabolism
|
| Reactions
|
| Myo-inositol 1-phosphate + Water → Myoinositol + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| IMPA1 |
| Gene Sequence
|
>834 bp
ATGGCTGATCCTTGGCAGGAATGCATGGATTATGCAGTAACCCTGGCAGGACAAGCTGGA
GAGGTGGTTCGTGAAGCGCTCAAGAATGAAATGAATATTATGGTTAAAAGTTCTCCGGCT
GATTTGGTAACTGCTACTGACCAAAAAGTTGAAAAAATGCTTATCACATCCATAAAGGAA
AAGTATCCATCTCACAGTTTCATTGGTGAGGAATCTGTGGCAGCTGGGGAAAAAAGTATC
TTAACCGACAACCCTACATGGATCATTGACCCTATTGATGGAACAACTAACTTTGTACAT
GGATTTCCTTTTGTAGCTGTTTCAATTGGCTTTGTGGTAAATAAAAAGATGGAGTTTGGA
ATTGTGTACAGTTGCCTGGAGGATAAGATGTACACTGGCCGGAAAGGAAAAGGTGCCTTT
TGTAATGGTCAAAAACTACAGGTTTCACACCAAGAAGATATTACCAAATCTCTCTTGGTG
ACAGAGTTGGGCTCTTCCAGAACACCAGAGACTGTGAGAATTATTCTTTCTAATATAGAA
AGGCTTCTTTGCCTTCCCATCCATGGGATCCGGGGTGTTGGAACAGCAGCTCTGAACATG
TGCCTGGTGGCCGCTGGGGCTGCGGACGCGTATTATGAAATGGGGATCCACTGCTGGGAT
GTTGCAGGCGCCGGCATCATTGTGACTGAAGCTGGCGGAGTGCTCCTGGATGTCACAGGT
GGACCATTTGATTTGATGTCACGAAGAGTAATTGCTTCAAGCAATAAAACATTAGCAGAA
AGGATAGCCAAAGAAATTCAGATAATACCTCTTCAAAGAGATGATGAAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 277 |
| Molecular Weight
| 30056.0 |
| Theoretical pI
| 4.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Inositol monophosphatase
MADPWQECMDYAVTLAGQAGEVVREALKNEMNIMVKSSPADLVTATDQKVEKMLITSIKE
KYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHGFPFVAVSIGFVVNKKMEFG
IVYSCLEDKMYTGRKGKGAFCNGQKLQVSHQEDITKSLLVTELGSSRTPETVRIILSNIE
RLLCLPIHGIRGVGTAALNMCLVAAGAADAYYEMGIHCWDVAGAGIIVTEAGGVLLDVTG
GPFDLMSRRVIASSNKTLAERIAKEIQIIPLQRDDED
|
| External Links |
|---|
| GenBank ID Protein
| AAA30589.1 |
| UniProtKB/Swiss-Prot ID
| P20456 |
| UniProtKB/Swiss-Prot Entry Name
| IMPA1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J05394 |
| GeneCard ID
| IMPA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
