| Identification |
|---|
| BMDB Protein ID
| BMDBP00458 |
| Secondary Accession Numbers
| None |
| Name
| Interleukin-1 receptor-associated kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| IRAK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity). |
| Pathways
|
- NF-kB Signaling Pathway
- Toll-Like Receptor Pathway 1
- Toll-Like Receptor Pathway 2
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| IRAK1 |
| Gene Sequence
|
>2157 bp
ATGGCCGGGGGGCCGGGCCCGGGAGACCCCGCCGTCCCCGGCGCCCAGCACTTCTTGTAC
GAGGTGCCTCCCTGGGTCATGTGCCGCTTCTACAAAGTGATGGACGCCCTGGAGCCCGCC
GACTGGTGCCAGTTCGCCGCCCTGATCGTCCGCGACCAGACCGAGCTGCGGCTGTGCGAG
CGCTCCGGGCAGCGCACAGCCAGCGTCCTGTGGCCGTGGATCAACCGCAACGCCCGCGTG
GCCGATCTCGTGCGCATCCTCACGCACCTGCAGCTGCTGCGGGCGCGGGATATCATCACT
GCTTGGCACCCTCCCGCCCCCCTTCTGCCCCCAAGCACCACCTCCCTGACACCCAGCAGC
ATCTCCGCACCCTCCGAGGCTGCGGTTCCTGGCCACCGGAAGTTGCCGTCTCTGGCCTCC
ACCTTCCTCTCCCCAGCTTTTCCAGGCTCTCAGACTCACTCTGACCCCGAGCTCTGCCCT
GGACCAAGCCCAGCTGCCCACCAGCCACCATTGCCATCTCCAGCCCCCTCATCTACCAAG
CCCAGCCCGGAGAGCCCCATGTCCCTCCTGCCAGGGGCCCCCTCTTCTTCATTCTGCTGG
CCCCTCCATGAGATTTGCCAGGGTACCCACGACTTCTCAGAGGAGCTCAAGATCGGGGAG
GGCGGCTTTGGCTGTGTGTACCGGGCGGTGATGAGGAACACCGTCTATGCTGTGAAGAGG
CTCAAGGAGGAGGCCGACCTGGAGTGGACCACAGTGAAGCAGAGCTTCCAGACTGAAGTG
CAGCAGCTGTCGCGGTTTCGTCACCCCAACATCGTGGACTTTGCCGGCTACTGTGCTCAG
AGTGGCTTCTACTGCCTTGTCTATGGCTTCCTGCCCAATGGCTCCCTGGAAGACCGCCTC
CATGTCCAGACACAGGCCTGGCCCCCTCTCTCCTGGCCTCAGCGACTGGACATCCTTCTG
GGCACGGCCCGGGCAATTCAGTTCTTACATCAAGATAGCCCCAGCCTCATCCATGGAGAT
GTCAAGAGTTCCAACGTCCTTCTGGATGAGAGACTGATGCCCAAACTGGGGGACTTCGGC
CTGGCCCGTCTCAGCCGGTTTACAGGGGCCAACCCCGGCCAGAGCAGTAGTGTGGCCCGG
ACTCGGACAGTGCGCGGCACCCTGGCCTACCTGCCCGAGGAGTACGTGAAGACCGGGAGG
CTGGCCGTAGACACCGACACCTTCAGCTTTGGCGTGGTGCTGCTGGAGACCCTGGCCGGC
CAGAGGGCCGTGAGGATGCATGGCGCCCAGCCCAAGTATCTGAAAGACTTGGTTGAAGAG
GAGGCGGAAGAGGCCGGGGTGACCCTGAAGGGCACTCAGACCGCAGTCCAAGGCGGGCCG
GCCGCAGACACGTGGGCCGCCCTAGTCGCCGCCCAGATCTACAAGAAGCACCTGGACCCC
AGGCCAGGGCCGTGCCCACCACAACTGGGCCTGGCCCTGGGCCAGCTGGCTTGCTGCTGC
CTGCACCGCCGAGCCAAGAGGAGACCCCCAATGACCCAGGTGTACCAGACACTGGAGGAG
CTGCAGGTGGTGGTGGCAGGGCCATGCCTGGAGCTGGAGGCTGCCAGCCGCAGCCCCCCT
TCCCCGCAAGAGAACTCCTACGTGTCCACCAGCGGGAGCGCCCTGAGCCGTGCCAGCCCC
TGGCAGCCCCTGGCAGCGCCCTTGGGGGCCCAGGCCCAGGCTACAGACTGGCCACAAAAA
GGTGCCAACCAGCCCGTGGAGAGTGACGAGAGCGTGTCTGACCTCTCTGCTGCCCTGCAC
TCCTGGCATCTGAGCCCCAGCTGCCCTGCGGGCCCAGGGGCCCCCAGCTGGGTGCCAGCA
CCCTTCGGGCAGGCTGCCTGCACCCAAGGGGGTGCCGCCCGAGAGTCGAGCTGTGGGAGC
GGCCCGGGTCTCCAGCCCACAGCTGTGGAAGGACCCCTCCTGGGCAGCTCCATGTCCTCG
CGACCCCCGCAGATCGTGATCAATCCGGCGCGACGGAAGATGCTGCAGAAGCTGGCATTG
TACGAGGACGGGGTCCTAGACAGCCTGCAGCTGCTCTCGTCCAGCTCTCTCCCAGACTCG
GGCCAGGACCTTCAGGACAGGCAGGGGCCCGAAGAGAGAGACGAGTTTCGGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 718 |
| Molecular Weight
| 77397.0 |
| Theoretical pI
| 6.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interleukin-1 receptor-associated kinase 1
MAGGPGPGDPAVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVRILTHLQLLRARDIITAWHPPAPLLPPSTTSLTPSS
ISAPSEAAVPGHRKLPSLASTFLSPAFPGSQTHSDPELCPGPSPAAHQPPLPSPAPSSTK
PSPESPMSLLPGAPSSSFCWPLHEICQGTHDFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKEEADLEWTTVKQSFQTEVQQLSRFRHPNIVDFAGYCAQSGFYCLVYGFLPNGSLEDRL
HVQTQAWPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDVKSSNVLLDERLMPKLGDFG
LARLSRFTGANPGQSSSVARTRTVRGTLAYLPEEYVKTGRLAVDTDTFSFGVVLLETLAG
QRAVRMHGAQPKYLKDLVEEEAEEAGVTLKGTQTAVQGGPAADTWAALVAAQIYKKHLDP
RPGPCPPQLGLALGQLACCCLHRRAKRRPPMTQVYQTLEELQVVVAGPCLELEAASRSPP
SPQENSYVSTSGSALSRASPWQPLAAPLGAQAQATDWPQKGANQPVESDESVSDLSAALH
SWHLSPSCPAGPGAPSWVPAPFGQAACTQGGAARESSCGSGPGLQPTAVEGPLLGSSMSS
RPPQIVINPARRKMLQKLALYEDGVLDSLQLLSSSSLPDSGQDLQDRQGPEERDEFRS
|
| External Links |
|---|
| GenBank ID Protein
| ABC47878.2 |
| UniProtKB/Swiss-Prot ID
| Q2LGB3 |
| UniProtKB/Swiss-Prot Entry Name
| IRAK1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ319075 |
| GeneCard ID
| IRAK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
