| Identification |
|---|
| BMDB Protein ID
| BMDBP00463 |
| Secondary Accession Numbers
| |
| Name
| Alkaline phosphatase, tissue-nonspecific isozyme |
| Synonyms
|
Not Available
|
| Gene Name
| ALPL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi). |
| Pathways
|
Not Available
|
| Reactions
|
| Pyridoxine 5'-phosphate + Water → Pyridoxine + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| ALPL |
| Gene Sequence
|
>1575 bp
ATGATTTCACCATTCTTACTGCTGGCTATCGGTACCTGTTTTGCCAGCTCCTTAGTGCCA
GAGAAAGAGAAAGATCCCAAGTACTGGCGAGACCAAGCTCAGCAGACCCTGAAAAATGCC
CTGAGGCTTCAGACTCTCAACACCAACGTGGCTAAGAACGTCATCATGTTCCTGGGAGAC
GGTATGGGCGTGTCCACCGTGACAGCTGCCCGCATCCTCAAGGGGCAGCTCCACCACAGC
CCTGGGGAGGAGACCAAGCTGGAGATGGACAAGTTTCCCTACGTGGCCCTCTCCAAGACG
TACAACACCAACGCCCAGGTCCCTGATAGCGCAGGCACCGCCACCGCCTACTTGTGTGGG
GTGAAGGCCAATGAGGGCACCGTGGGGGTGAGCGCAGCAACCCAGCGCTCCCAGTGTAAC
ACCACTCAGGGCAACGAGGTGACCTCCATCCTGCGCTGGGCCAAGGACGCAGGGAAATCC
GTGGGCATCGTGACCACCACGCGCGTGAACCACGCCACCCCCAGCGCCTCCTACGCCCAC
TCTGCTGACCGGGACTGGTACTCGGACAACGAGATGCCCCCGGAGGCCCTGAGCCAGGGC
TGCAAGGACATCGCCTACCAGCTCATGTACAACATTAAGGACATCGAGGTGATCATGGGC
GGCGGCCGGAAGTACATGTTCCCCAAGAACAGAACCGATGTGGAGTATGAGCTGGATGAG
AAGGCCAGAGGCACGAGGCTGGACGGCCTGAACCTCATCGACATCTGGAAGAGCTTCAAA
CCGAAACACAAGCACTCTCACTATGTCTGGAACCGCACTGATCTCCTGGCCCTTGACCCC
CACAGCGTGGACTACCTCTTGGGTCTCTTTGAGCCGGGGGACATGCAGTACGAACTCAAC
AGGAACAATGCGACTGACCCTTCACTCTCTGAGATGGTAGAGATGGCCATCAGGATCCTG
AACAAGAACCCCAAAGGCTTCTTCCTGCTGGTGGAAGGGGGCAGGATTGACCACGGGCAC
CACGAGGGCAAAGCCAAGCAGGCACTGCACGAGGCGGTGGAGATGGACCAGGCCATCGGG
CAGGCAGGTGCTATGACCTCCGTAGAAGACACACTGACCGTTGTCACCGCTGACCACTCC
CACGTCTTTACCTTTGGCGGGTACACCCCCCGTGGCAACTCGATCTTTGGTCTGGCCCCC
ATGGTGAGTGACACAGACAAGAAGCCGTTCACCGCCATCCTGTACGGCAACGGGCCTGGC
TACAAGGTGGTGGGTGGTGAGCGAGAGAATGTCTCCATGGTGGACTACGCTCACAATAAC
TACCAGGCGCAGTCCGCGGTGCCCCTGCGCCACGAGACCCACGGCGGCGAGGACGTGGCC
GTCTTTGCCAAGGGCCCCATGGCGCACCTGCTGCACGGCGTCCAAGAGCAGAACTACATC
CCCCACGTGATGGCCTACGCAGCCTGCATTGGTGCCAACCGCGACCACTGTGCCTCAGCC
AGCTCGTCCGGCAGCCCCTCCCCCGGCCCCCTGCTGCTCCTCCTGGCCCTGCTGCCCCTG
GGCAGCCTGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 524 |
| Molecular Weight
| 57193.0 |
| Theoretical pI
| 6.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alkaline phosphatase, tissue-nonspecific isozyme
MISPFLLLAIGTCFASSLVPEKEKDPKYWRDQAQQTLKNALRLQTLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHSPGEETKLEMDKFPYVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATQRSQCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSASYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIEVIMGGGRKYMFPKNRTDVEYELDE
KARGTRLDGLNLIDIWKSFKPKHKHSHYVWNRTDLLALDPHSVDYLLGLFEPGDMQYELN
RNNATDPSLSEMVEMAIRILNKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIG
QAGAMTSVEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYI
PHVMAYAACIGANRDHCASASSSGSPSPGPLLLLLALLPLGSLF
|
| External Links |
|---|
| GenBank ID Protein
| AAA30380.1 |
| UniProtKB/Swiss-Prot ID
| P09487 |
| UniProtKB/Swiss-Prot Entry Name
| PPBT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M18443 |
| GeneCard ID
| ALPL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
