| Identification |
|---|
| BMDB Protein ID
| BMDBP00470 |
| Secondary Accession Numbers
| None |
| Name
| Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Synonyms
|
Not Available
|
| Gene Name
| ILKAP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ILKAP |
| Gene Sequence
|
>1113 bp
ATGGACCTGTTCGGGGACCTGCCGGAGCCCGAGCGCTCGCCGCGGCCGGCTGCTGGCTCT
GGGGGACCTTTGCTTTTTGACGATCTCCCGCCAGCCAGCAGTGGCGATTCAGGTTCTCTT
GACACTTCGTTATCCGAGGAGGTAAAGAATGAAGGGAAAGGAGCAAAGAGAAAAGCCTCT
GATGAAGAGAAGAATGGGAGTGAAGAGCTTGTGGAAAAGAAAGTTTGTAAAGCCTCTTCG
GTGATCTTCAGCCTGAAAGGCTACGTGGCTGAGCGGAAGGGCGAGCGGGAAGAGATGCAG
GATGCCCACGTCATCCTGAACGACATCACCGCGGAGTGCCAGCCCCCGTCCGCTCTCGTC
ACCCGGGTTTCATACTTTGCTGTTTTTGATGGACATGGAGGAATTCGAGCCTCAAAATTC
GCCGCACAGAATTTGCATCAGAACTTAATCAGGAAATTTCCTAAAGGAGATGGAATCAGC
GTAGAGAAAACGGTGAAAAGGTGCCTTCTGGACACCTTCAAGCATACTGATGAAGAGTTC
CTTAAGCAAGCCTCAAGCCAGAAACCTGCCTGGAAAGATGGGTCCACTGCCACGTGTGTG
CTGGCCGTAGACAACACTCTTTACATCGCCAACCTGGGGGACAGTCGGGCAATCCTTTGT
CGTTACAATGAGGAGAGTCAAAAACACGCGGCCTTAAGCCTCAGCAAGGAGCATAATCCA
ACCCAGTATGAAGAACGAATGAGAATACAGAAGGCCGGAGGGAATGTCAGGGACGGGCGT
GTCCTGGGTGTGCTGGAGGTGTCCCGCTCCATCGGGGACGGGCAGTACAAGCGCTGCGGG
GTCACCTCGGTGCCGGACATCAGACGCTGCCAGCTGACCCCCAACGACAGGTTTATTTTG
CTGGCCTGTGATGGCCTCTTCAAGGTCTTTACCCCAGAAGAAGCCGTGAACTTCATCTTG
TCCTGCCTGGAGGACGAGAAGATCCAAAGGCGGGAAGGGAAGCCCACTGTGGATGCCCGC
TACGAAGCCGCCTGCAACAGGCTGGCCAACAAGGCGGTGCAGCGGGGCTCGGCGGACAAC
GTCACCGTGATGGTGGTGCGGATAGGGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 370 |
| Molecular Weight
| 40622.0 |
| Theoretical pI
| 7.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Integrin-linked kinase-associated serine/threonine phosphatase 2C
MDLFGDLPEPERSPRPAAGSGGPLLFDDLPPASSGDSGSLDTSLSEEVKNEGKGAKRKAS
DEEKNGSEELVEKKVCKASSVIFSLKGYVAERKGEREEMQDAHVILNDITAECQPPSALV
TRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDGISVEKTVKRCLLDTFKHTDEEF
LKQASSQKPAWKDGSTATCVLAVDNTLYIANLGDSRAILCRYNEESQKHAALSLSKEHNP
TQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFIL
LACDGLFKVFTPEEAVNFILSCLEDEKIQRREGKPTVDARYEAACNRLANKAVQRGSADN
VTVMVVRIGL
|
| External Links |
|---|
| GenBank ID Protein
| AAI22678.1 |
| UniProtKB/Swiss-Prot ID
| Q0IIF0 |
| UniProtKB/Swiss-Prot Entry Name
| ILKAP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122677 |
| GeneCard ID
| ILKAP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
