1.0 2018-05-07 22:22:33 UTC 2020-05-20 21:10:39 UTC BMDBP00473 Enzyme STK4 Involved in ATP binding Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. BMDB0000547 Magnesium 13 >1464 bp ATGGAGACGGTGCAGCTTAGGAACCCGCCGCGCCGGCAGCTGAAAAAGTTGGATGAAGAT AGTTTAACTAAACAACCGGAAGAAGTGTTTGATGTCTTAGAGAAACTTGGAGAAGGGTCC TATGGCAGCGTGTACAAAGCTATTCATAAAGAGACCGGTCAGATTGTTGCTATTAAGCAA GTTCCTGTGGAATCAGACCTGCAGGAGATAATCAAAGAAATCTCTATCATGCAGCAATGT GACAGCCCTCATGTAGTCAAATATTACGGCAGTTACTTTAAGAACACAGACTTGTGGATC GTGATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATTATTCGATTACGAAATAAAACG TTAACAGAAGATGAAATAGCTACAATATTACAGTCAACACTTAAGGGACTGGAATATCTT CATTTTATGAGAAAAATACACCGAGATATCAAAGCAGGAAATATTTTGCTCAATACAGAA GGTCATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAG CGAAATACAGTGATAGGAACACCTTTTTGGATGGCTCCAGAAGTGATCCAGGAAATTGGG TACAACTGTGTAGCAGACATCTGGTCATTGGGAATAACAGCCATAGAAATGGCTGAAGGA AAGCCTCCATATGCTGATATCCATCCAATGAGGGCCATCTTCATGATTCCTACCAACCCA CCCCCCACATTCCGAAAGCCGGAACTGTGGTCAGATAGCTTCATGGATTTTGTGAAGCAG TGTCTTGTCAAGAGCCCCGAGCAGAGAGCCACAGCCACTCAACTCCTCCAGCACCCGTTT GTCAAGAGTGCCAAAGGAGTGTCCATACTGCGGGACTTGATTAATGAAGCCATGGACGTG AAGCTGAAACGCCAGGAGGCCCAGCAGCGGGAGGTGGACCAGGAGGAGGAAGAAAACTCT GAGGAGGATGAGCTAGATTCTGGCACGATGGTCCGAGCAGCAGGGGATGAGATGGGCACT GTCCGAGTAGCCAGCAGCATGAGTGACGGGGCCAATACGATGATCGAGCACGATGACACG TTGCCGTCCCAGCTGGGCACCATGGTGATCAACACGGAGGACGAGGAAGAAGAAGGCACA ATGAAAAGAAGGGACGAGACCATGCAGCCTGCCAGACCATCGTTCCTTGAATATTTCGAA CAAAAAGAAAAGGAAAATCAGATCAACAGCTTCGGCAAGAGTGTCCCTGGCCCATTGCAG AACTCCTCAGATTGGAAAGTTCCCCAGGATGGAGACTATGAATTCCTGAAGAGTTGGACG GTGGAAGACCTTCAGAAGAGGCTCCTGGCCCTGGACCCCATGATGGAGCAGGAGATTGAG GAGATCCGGCAGAAGTACCAGTCGAAGCGGCAGCCCATCCTGGACGCCATTGAGGCCAAG AAGCGGCGGCAGCAGAACTTCTGA 487 55587.0 4.68 None >Serine/threonine-protein kinase 4 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP PPTFRKPELWSDSFMDFVKQCLVKSPEQRATATQLLQHPFVKSAKGVSILRDLINEAMDV KLKRQEAQQREVDQEEEENSEEDELDSGTMVRAAGDEMGTVRVASSMSDGANTMIEHDDT LPSQLGTMVINTEDEEEEGTMKRRDETMQPARPSFLEYFEQKEKENQINSFGKSVPGPLQ NSSDWKVPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK KRRQQNF AAX08921.1 Q5E9L6 STK4_BOVIN BT020904 STK4