| Identification |
|---|
| BMDB Protein ID
| BMDBP00474 |
| Secondary Accession Numbers
| None |
| Name
| Mitogen-activated protein kinase kinase kinase 7 |
| Synonyms
|
Not Available
|
| Gene Name
| MAP3K7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (By similarity). Promotes TRIM5 capsid-specific restriction activity (By similarity). Phosphorylates RIPK1 at 'Ser-321' which positively regulates RIPK1 interaction with RIPK3 to promote necroptosis but negatively regulates RIPK1 kinase activity and its interaction with FADD to mediate apoptosis (By similarity). |
| Pathways
|
- FAS signaling pathway ( CD95 )
- NF-kB Signaling Pathway
- Toll-Like Receptor Pathway 1
- Toll-Like Receptor Pathway 2
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| MAP3K7 |
| Gene Sequence
|
>1740 bp
ATGTCTACAGCCTCCGCCGCTTCTTCTTCTTCCTCGTCTTCCGCCGGTGAGATGATCGAA
GCCCCCTCCCAAGTCCTCAACTTTGAAGAGATAGACTACAAGGAGATCGAGGTGGAAGAG
GTTGTTGGAAGAGGAGCTTTTGGAGTAGTATGCAAAGCCAAGTGGAGAGCAAAAGATGTT
GCCATTAAACAAATAGAAAGTGAATCTGAGAGGAAAGCTTTTATTGTAGAGCTTCGACAG
TTATCGCGTGTGAACCATCCTAACATCGTAAAGCTATATGGAGCCTGCTTGAATCCAGTG
TGTCTTGTAATGGAATATGCTGAAGGGGGCTCCTTGTATAATGTGCTGCATGGTGCTGAA
CCATTGCCATATTACACCGCTGCCCACGCAATGAGTTGGTGTTTACAGTGTTCCCAAGGA
GTGGCTTATCTTCACAGCATGCAGCCCAAAGCTCTAATCCACAGGGACCTGAAACCACCA
AACTTGCTGCTGGTTGCAGGGGGGACAGTTTTAAAAATCTGTGATTTTGGTACAGCCTGT
GACATTCAGACTCACATGACCAACAATAAGGGGAGTGCTGCTTGGATGGCACCTGAAGTT
TTTGAAGGTAGCAATTACAGTGAAAAATGTGATGTCTTCAGCTGGGGTATTATCCTTTGG
GAAGTGATAACACGTCGGAAACCCTTTGATGAAATTGGTGGCCCGGCTTTCCGTATCATG
TGGGCTGTTCATAACGGTACTCGACCACCACTGATCAAAAATTTACCTAAGCCCATTGAG
AGCCTGATGACTCGTTGTTGGTCTAAAGATCCTTCTCAGCGCCCTTCAATGGAGGAAATT
GTGAAAATAATGACTCACTTGATGCGGTACTTTCCAGGAGCAGATGAGCCGTTACAATAT
CCTTGTCAGTATTCAGATGAAGGACAGAGCAACTCTGCTACCAGTACAGGCTCCTTCATG
GACATCACTTCTACAAACACCAGTAATAAAAGTGACACTAACATGGAACAAGTTCCTGCC
ACAAATGATACAATTAAACGCTTAGAATCAAAATTGTTGAAAAACCAGGCAAAACAACAG
AGTGAATCTGGGCGTTTGAGTTTGGGAGCTTCTCGTGGGAGCAGCGTGGAGAGCTTGCCC
CCAACCTCTGAAGGCAAGAGGATGAGTGCCGATATGTCTGAAATAGAAGCCAGGATTGCT
GCAACCACAGGCAACGGGCAGCCAAGACGTAGATCCATCCAAGACTTGACTGTTACTGGA
ACAGATCCTGGTCAGGTGAGCAGTAGGTCATCCAGTCCTAGCGTCAGAATGATCACTACC
TCAGGACCAACCTCAGAAAAGCCAGCTCGCAGTCATCCATGGACCCCTGATGATTCCACA
GATACCAATGGATCAGATAATTCCATCCCAATGGCATATCTTACACTGGATCACCAACTA
CAGCCTCTAGCACCATGCCCAAACTCCAAAGAATCTATGGCAGTGTTTGAACAGCATTGT
AAGATGGCACAGGAATACATGAAAGTCCAAACAGAAATTGCATTGTTATTACAGAGAAAG
CAGGAACTAGTTGCAGAACTGGACCAGGATGAAAAGGACCAGCAAAATACATCTCGTCTG
GTGCAGGAACATAAAAAGCTTTTAGATGAAAACAAAAGCCTTTCAACTTACTATCAGCAA
TGCAAAAAACAGCTAGAGGTCATCAGGAGTCAGCAGCAAAAACGACAAGGCACTTCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 579 |
| Molecular Weight
| 64216.0 |
| Theoretical pI
| 6.64 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitogen-activated protein kinase kinase kinase 7
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
PCQYSDEGQSNSATSTGSFMDITSTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG
TDPGQVSSRSSSPSVRMITTSGPTSEKPARSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL
QPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRL
VQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
|
| External Links |
|---|
| GenBank ID Protein
| AAI33405.1 |
| UniProtKB/Swiss-Prot ID
| A2VDU3 |
| UniProtKB/Swiss-Prot Entry Name
| M3K7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133404 |
| GeneCard ID
| MAP3K7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
