| Identification |
|---|
| BMDB Protein ID
| BMDBP00475 |
| Secondary Accession Numbers
| None |
| Name
| Mitogen-activated protein kinase kinase kinase 13 |
| Synonyms
|
Not Available
|
| Gene Name
| MAP3K13 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity). |
| Pathways
|
- Toll-Like Receptor Pathway 1
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| MAP3K13 |
| Gene Sequence
|
>2901 bp
ATGGCCAACCCTCAGGAGCACCTGAGCTGCTCCTCTTCTCCACGTTTGCCTTTGAGTGAA
AACAAAACCTTCAATGGACTACAAGATGACCTCGCACCTATGGGGAGCCACGCTTCCCCC
AAGCTTCTTAAGGACCAGCAGGAAAAGGGCATGGTGCAAACTGAGCTAGCTGAAGGCACG
AACAGCCCCATCACCACAACAGTGTTGACAAGCATAAGTGAGGATTCCAGGGACCAGTTT
GAGAACAGCGTTCTTCAGCTAAGGGAACAAGATGAATCAGAGATGGCCATGTCTCATGGG
AACAGCAACACTGTGGATGGAGAGGGCACAAGTGGAACTGAAGACATCAAGATTCAGTTC
AGCAGGTCGGGCAGCGGCAGTGGTGGGTTTCTTGAAGGACTATTTGGATGCTTAAGGCCT
GTATGGAATATCATTGGAAAGGCATATTCCACTGATTACAAATTGCAGCAGCAAGATACT
TGGGAAGTGCCATTTGAGGAGATCTCAGAGCTGCAGTGGCTGGGTAGTGGAGCCCAGGGA
GCTGTCTTCTTGGGCAAGTTCCGAGCGGAGGAGGTGGCCATCAAGAAAGTGAGAGAACAG
AATGAGACGGATATCAAGCATTTGAGGAAGTTGAAGCACCCTAACATCATCGCTTTCAAG
GGTGTTTGTACTCAGGCCCCATGTTACTGTATCATCATGGAATACTGTGCCCATGGACAA
CTCTATGAGGTTTTGCGAGCTGGCAGGAAAATCACACCTCGATTGCTAGTAGACTGGTCC
ACGGGAATTGCAAGTGGAATGAATTATTTGCACCTTCATAAAATTATTCATCGTGATCTC
AAATCACCTAATGTTTTAGTGACTCACACAGATGCAGTAAAAATTTCAGATTTTGGTACA
TCTAAGGAACTCAGTGATAAGAGTACCAAGATGTCCTTCGCTGGCACTGTCGCCTGGATG
GCACCAGAAGTGATACGGAATGAACCTGTCTCTGAAAAAGTTGATATATGGTCTTTTGGA
GTGGTGCTTTGGGAGCTGCTCACAGGGGAGATTCCGTACAAAGATGTGGACTCTTCAGCC
ATTATTTGGGGGGTTGGAAGCAATAGCCTACACCTTCCAGTTCCTTCCACTTGCCCTGAT
GGATTCAAAATCCTTATGAAGCAGACATGGCAGAGTAAAACTCGCAACCGACCTTCTTTT
CGGCAGACGCTCATGCATTTGGACATCGCATCTGCAGATGTACTTGCCACCCCACAAGAA
ACCTATTTCAAGTCTCAGGCTGAATGGAGAGAAGAAGTGAAAAAGCACTTTGAGAAGATC
AAGAGTGAAGGAACCTGTATCCACCGATTAGATGAAGAACTTATTCGAAGGCGCAGAGAA
GAGCTCAGGCATGCTTTGGATATTCGTGAGCACTATGAGCGGAAACTTGAGCGGGCTAAT
AATTTGTACATGGAACTGAGTGCCATCATGCTGCAGCTAGAGATGCGGGAGAAGGAGCTC
ATCAAGCGTGAGCAGGCTGTGGAGAAGAAGTATCCTGGGACCTACAAACGACATCCTGTC
CGTCCAATAATCCACCCCAATGCCATGGAGAAGCTCATGAAGAGGAAAGGCATGCCACAC
AGACCTGGGATGCAGGCCAAGCGGCCAGATCTGTTGAGATCTGAAGGTATCCCCAGTGTG
GAAGTGGCTCCCACAGCATCCCCTTTATCCGGAAGTCCCAAACTGTCCTCCTCCAGCAGC
AAGAGCCGATATCGGAGCAAACCACGCCACCGACGTGGGAACAGCCGAGGCAGCCACGGT
GACTTTGCGGCCATCTTGAAAAACCAGCCAGCCCAGGAGGATTCGCCCCATCCCACTTCC
CTCCACCAAGCTGAGCCCCAGTACCCATCTTCCCAGCACCATAATCTTCTGCAGCAGCAA
TACCAGCAACCCCCACCTGCCATGTCGCAGAGTCACCATCCCAGACTCAATATGCACGGA
CAGGACATTGCCACCTGCCCCAACAACCTGAGGTACTTTGGTCCTGCAGCAGCCCTGCGG
AGCCCACTCAGCAACCACTCTCAAAGACAGATGCCTGGCTCTAGCCCTGACCTCATCTCC
ACGGCCATGGCGGCAGATTGTTGGAGAAGTTCTGAGCCTGACAAGGGCCAGGCTGGCCCC
TGGGGCTGTTGTCAGGCTGACCCCTATGACCCCTGCCTCCAGTGCAGGCCAGAACAGCAT
GGGTCCCTAGACGTCCCCTCGGCCAAGCCGGTAGGGAGGAGCCCCAGCCTTTTCAAGCCA
CCAGCACACAATCCCCTCTTGGAAAATGCCCAGGGTTCTGAGAAAATGGAAGAAAATGAA
TTCAGCGGTTATCGGTCTGCATCATCCCTTGGCGCCTCTCATCACATCACTCCCCCAGTG
CTACCTCGCAAAACAAGGCCACTTCAGAAGAGTGGAGATGACTCCTCTGAAGAGGAAGAA
GGGGAAGTAGATAGTGAAGTTGAATTTCCACGAAGACAGAGGCCCCATCGCTGTATCAGC
AGCTGCCAGTCATATTCCACCTTTAGCTCTGAGAATTTCTCTGTGTCTGATGGCGAGGAA
GGAAATACCAGTGACCACTCAAACAGCCCTGATGAGTTAGCAGATAAACTCGAAGATCAC
CTGGCAGAGAAGCTTGATGACCTGCTGTCCCAGACGCCGGAGATCCCCATTGAGATATCC
TCACATTCGGACGGGCTCTCTGACAAGGAGTGTGCTGTGCGTCGCGTGAAAACACAGATG
TCTCTGGGCAAGCTATGTGCGGAGGAACGTGGCTATGAGAATCCTATGCAGTTTGAAGAA
TCGGACTGTGACTCTTCAGATGGGGAGTGTTCTGATGCCACAGTCAGGACCAATAAACAC
TACAGCTCTGCTACCTGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 966 |
| Molecular Weight
| 108152.0 |
| Theoretical pI
| 6.6 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mitogen-activated protein kinase kinase kinase 13
MANPQEHLSCSSSPRLPLSENKTFNGLQDDLAPMGSHASPKLLKDQQEKGMVQTELAEGT
NSPITTTVLTSISEDSRDQFENSVLQLREQDESEMAMSHGNSNTVDGEGTSGTEDIKIQF
SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKTRNRPSFRQTLMHLDIASADVLATPQE
TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGMPH
RPGMQAKRPDLLRSEGIPSVEVAPTASPLSGSPKLSSSSSKSRYRSKPRHRRGNSRGSHG
DFAAILKNQPAQEDSPHPTSLHQAEPQYPSSQHHNLLQQQYQQPPPAMSQSHHPRLNMHG
QDIATCPNNLRYFGPAAALRSPLSNHSQRQMPGSSPDLISTAMAADCWRSSEPDKGQAGP
WGCCQADPYDPCLQCRPEQHGSLDVPSAKPVGRSPSLFKPPAHNPLLENAQGSEKMEENE
FSGYRSASSLGASHHITPPVLPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDHLAEKLDDLLSQTPEIPIEIS
SHSDGLSDKECAVRRVKTQMSLGKLCAEERGYENPMQFEESDCDSSDGECSDATVRTNKH
YSSATW
|
| External Links |
|---|
| GenBank ID Protein
| AAI51465.1 |
| UniProtKB/Swiss-Prot ID
| A7MBB4 |
| UniProtKB/Swiss-Prot Entry Name
| M3K13_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151464 |
| GeneCard ID
| MAP3K13 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
