| Identification |
|---|
| BMDB Protein ID
| BMDBP00483 |
| Secondary Accession Numbers
| None |
| Name
| Interleukin-1 receptor-associated kinase 4 |
| Synonyms
|
Not Available
|
| Gene Name
| IRAK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| IRAK4 |
| Gene Sequence
|
>1386 bp
ATGAACAAACCCATAACAGCATCAACATACGTGCGCTGCCTCAGTCTTGGACTAATTAGA
AAGCTGTCCGATTTTATTGATCCTCAAGAAGGATGGAAGAAGTTAGCAGTCGCTATTAAA
AAACCATCTGGTGATGATAGATACAATCAGTTTCACATAAGGAGATTTGAAGCATTACTG
CAAATTGGAAAAAGCCCCACGTGTGAGTTACTGTTTGACTGGGGCACCACAAATTGCACA
GTTGGTGATCTTGTGGATATTTTGGTCCAAAATGAGTTTTTTGCCCCTGCAAGTCTTTTG
CTACCAGATGCTGTACCCAAAAATGTTAATACACTGCCTTCTAAAGTCACTGTAGTAGCA
GTTCAGCAGAAACCGAAGCCCCTCTGTGGCAAAGACAGGACATCTGTGATATCTGATGAG
AATCCTGAACAAAACTATGTGCTACCTGACTCCTCAAGTCCAGAAAATACAAGTTTAGAA
TTTAGTGATACACGTTTTCACAGTTTTTCATTTTTTGAATTGAAGGATGTCACAAATAAC
TTTGATGAACGGCCCATTTCTGTTGGTGGTAACAAAATGGGAGAAGGAGGGTTTGGAGTT
GTGTATAAAGGCTACGTGAACAACAGGACTGTAGCAGTGAAGAAGCTTGCAGCAATGGTT
GACATTAGTACTGAAGAACTGAAACAACAATTTGATCAAGAAATAAAAGTAATGGCAAAG
TGTCAACATGAAAACTTAGTAGAATTACTTGGTTTCTCAAGTGATGGAGATGACCTCTGC
TTAGTATATGTTTACATGCCCAATGGTTCATTGCTGGACAGACTGTCTTGCTTGGATGGT
ACTCCCCCACTCTCTTGGAACATGAGATGCAAGATTGCCCAGGGTGCAGCTAATGGCCTC
AGTTATTTACATGAAAACCATCATATTCATAGAGATATTAAAAGTGCAAATATCTTATTA
GATGAAGACTTTACAGCCAAAATATCTGACTTTGGGCTTGCACGGGCTTCTGAGAAGTTT
GCCCAGACAGTCATGACTAGCAGAATTGTGGGAACAACAGCTTATATGGCACCTGAAGCT
TTGCGAGGAGAAATTACACCCAAATCTGACATCTACAGCTTTGGTGTGGTTTTGCTAGAA
ATAATAACTGGACTTCCAGCTGTGGATGAACACCGTGAACCTCAGTTATTGCTAGATATT
AAAGAAGAAATTGAAGATGAAGAAAAGACAATTGAAGATTATGTTGATAGGAAGATGAAT
GACATTGATTCCACTTCCATTGAAACTATGTACTCTGTTGCCAGTCAGTGTCTGCATGAA
AAGAAAAATAAGAGACCAGACATTAAGAAGGTTCAACAGCTGCTAGAAGAAATGACAGGT
TCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 461 |
| Molecular Weight
| 51575.0 |
| Theoretical pI
| 4.87 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Interleukin-1 receptor-associated kinase 4
MNKPITASTYVRCLSLGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QIGKSPTCELLFDWGTTNCTVGDLVDILVQNEFFAPASLLLPDAVPKNVNTLPSKVTVVA
VQQKPKPLCGKDRTSVISDENPEQNYVLPDSSSPENTSLEFSDTRFHSFSFFELKDVTNN
FDERPISVGGNKMGEGGFGVVYKGYVNNRTVAVKKLAAMVDISTEELKQQFDQEIKVMAK
CQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWNMRCKIAQGAANGL
SYLHENHHIHRDIKSANILLDEDFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA
LRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYVDRKMN
DIDSTSIETMYSVASQCLHEKKNKRPDIKKVQQLLEEMTGS
|
| External Links |
|---|
| GenBank ID Protein
| AAI14721.1 |
| UniProtKB/Swiss-Prot ID
| Q1RMT8 |
| UniProtKB/Swiss-Prot Entry Name
| IRAK4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114720 |
| GeneCard ID
| IRAK4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
