| Identification |
|---|
| BMDB Protein ID
| BMDBP00509 |
| Secondary Accession Numbers
| |
| Name
| Acyl-coenzyme A synthetase ACSM1, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACSM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754). |
| Pathways
|
Not Available
|
| Reactions
|
| Dodecanoic acid + Adenosine triphosphate + Coenzyme A → Lauroyl-CoA + Adenosine monophosphate + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| ACSM1 |
| Gene Sequence
|
>1734 bp
ATGCAAAGGCTGATGAAGTTTCGGGTCCTCTGGGGCATCCACATGTCCTGCCCTGGCTTC
CACCATGCCCCTCAGCACCTGCGCTGCCGATCTTTATCAGGAGCTGGAACCCTAAGATGG
AATGACTATGACAGACCTGAGGAATTTAACTTTGCAAGTGATGTACTGGACCACTGGACT
CAAATGGAGAAGGAGGGCAAGAGAAGTCCAAACCCAGCCCTGTGGTGGGTGAACGATCAA
GGGGATGAAGTGAAGTGGAGCTTCAGAGAGATGACAGACTTAACCTGTCGCACAGCCAAC
GTCCTGACACAGACCTGCGGCCTTCAGACGGGAGACCGTCTAGCGTTGATTTTGCCTCGA
GTGCCTGAGTGGTGGCTTGTGTGTGTGGGCTGCATCCGAACAGGGATCATCTTCATGCCA
GGGACCACCCAGATGAAGGCCAAGGACATTCTCTACCGACTACAAGTATCTGGAGCCAAA
GCCATCGTGACCACAGATACCCTTGCCCCAGAGGTGGAGTCTGTGGCACCTGAGTGTCCT
TCTCTGAAAACCAAGCTCCTGGTGTCTGACCACAGCCGTGAAGGGTGGCTGGACTTCCGA
TCACTGGTTAAATCAGCCTCCCCAGATCACATCTGTATTAAGTCAAAGACCCTGGACCCA
ATGGCCATCTTCTTCACCAGTGGGACCACGGGCTTCCCCAAGATGGCAAAGCACAGCCAC
GGATTCGCTTTACGATCCTATTTCCCAGCATGCAGGAAATTGTTGCAGCTGAAGATGTCT
GATGTCTTCTGGTGCCTGTCAGACACAGGCTGGATTCTGGCTGCCTTGGGGTCCCTGCTT
GAACCATGGACAGCGGGGTCTACAGTCTTTGCTCATCATCTGCCTCAGTTTGACCCTAAG
GTCATTATAGAGACATTTTTCAAATATCCAATTACCCAATGCCTTGCTGCACCTTCTGTA
TATCGAATGATTTTGCAGCAGAATTACACCAGTCTTAGGTTCCCCACTCTGGAACACTGC
TGTACTGGTGGGGAAGCCCTGCTGCCCGAGGAGCAAGAACAGTGGAAAAGACAGACAGGT
GTTCTGCTCTACCAGGCCTATGGACAGTCAGAAACGGGAATAAGCTGTGGCACTCTCCGG
GGGATGAAGATCAAGCCAGGTTCCATGGGGAAGGCCATCCCACCCTTTGACATTCAGATC
ATTGATGACAAGGGCAATATCCAGCCTCCCAACACGGAAGGAAACATTGGCATCAGGATC
AAGCCCACCAGGCCCATAGGCCTCTTCATGTACTATGAGAATAACCCAGAGAAAACAGCT
GAAGTGGAATGTGGGGACTTTTATAACACTGGGGACAGAGCAACTATTGACGAAGAGGGC
TACTTCTGGTTCCTTGGGAGGAGTGACGATGTCATCAATGCATCCGGATACCGCGTTGGG
CCAGCAGAAGTAGAGAATGCCCTGGCAGAGCACCCAGCGGTGGCTGAGTCTGCTGTGGTG
AGCAGCCCGGACCCGGTTCGAGGGGAGGTAGTGAAGGCATTTATTGTCCTGAACCCGGAA
TTCTCGAGCCGTGACCCAGGCGAGCTCACCAAGGAGCTGCAGCAGCATGTCAAGTCAGTG
ACAGCCCCATACAAGTACCCGAGGAAGGTGGAGTTTGTCTCAGAGCTGCCCAAAACCATC
ACTGGCAAGATAAAGAGAAGTGAGCTTCGGAAGAAGGAGTTTGGTCAGAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 577 |
| Molecular Weight
| 64923.0 |
| Theoretical pI
| 7.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acyl-coenzyme A synthetase ACSM1, mitochondrial
MQRLMKFRVLWGIHMSCPGFHHAPQHLRCRSLSGAGTLRWNDYDRPEEFNFASDVLDHWT
QMEKEGKRSPNPALWWVNDQGDEVKWSFREMTDLTCRTANVLTQTCGLQTGDRLALILPR
VPEWWLVCVGCIRTGIIFMPGTTQMKAKDILYRLQVSGAKAIVTTDTLAPEVESVAPECP
SLKTKLLVSDHSREGWLDFRSLVKSASPDHICIKSKTLDPMAIFFTSGTTGFPKMAKHSH
GFALRSYFPACRKLLQLKMSDVFWCLSDTGWILAALGSLLEPWTAGSTVFAHHLPQFDPK
VIIETFFKYPITQCLAAPSVYRMILQQNYTSLRFPTLEHCCTGGEALLPEEQEQWKRQTG
VLLYQAYGQSETGISCGTLRGMKIKPGSMGKAIPPFDIQIIDDKGNIQPPNTEGNIGIRI
KPTRPIGLFMYYENNPEKTAEVECGDFYNTGDRATIDEEGYFWFLGRSDDVINASGYRVG
PAEVENALAEHPAVAESAVVSSPDPVRGEVVKAFIVLNPEFSSRDPGELTKELQQHVKSV
TAPYKYPRKVEFVSELPKTITGKIKRSELRKKEFGQK
|
| External Links |
|---|
| GenBank ID Protein
| AAD39140.1 |
| UniProtKB/Swiss-Prot ID
| Q9BEA2 |
| UniProtKB/Swiss-Prot Entry Name
| ACSM1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF126145 |
| GeneCard ID
| ACSM1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
