| Identification |
|---|
| BMDB Protein ID
| BMDBP00512 |
| Secondary Accession Numbers
| None |
| Name
| Peroxisomal NADH pyrophosphatase NUDT12 |
| Synonyms
|
Not Available
|
| Gene Name
| NUDT12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. |
| Pathways
|
- Nicotinate and Nicotinamide Metabolism
|
| Reactions
|
| NAD + Water → Nicotinamide ribotide + Adenosine monophosphate |
details
|
| Nicotinic acid adenine dinucleotide + Water → Nicotinic acid mononucleotide + Adenosine monophosphate |
details
|
| Nicotinic acid adenine dinucleotide + Water →2 Nicotinic acid mononucleotide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| NUDT12 |
| Gene Sequence
|
>1335 bp
ATGTCTTCTGTAAAAAGAAGTCTGAATCAAGAAATAATATCCCAGTTTCACTATTCAGCT
GCAGAAGGAGATATTGCCAAGTTAACAGCAATACTCAGTCATTCTCCATCTCTTCTCAAT
GAAACTTCTGAAAATGGCTGGAGTGCTTTAATATGCGACAGATCCATTGTCAACAAATCA
AGGCAGACTGCACTGGATATAGCTAAATTTTGGGGTTATAAGCATATAGCTAACTTATTA
GCTAATGCTAAAGGTGGGAAGAAGCCTTGGTTCCTAACCAATGAAGTGGAAGAATGTGAA
AATTATTTTAGCAAGACACTACTGGACCGGAAAAGTGAAAAAAGAAATAATTCTGACTGG
CTGTTAGCAAAAGAAAGCCATCCAGCCACAGTTTATATCCTTTTCTCAGATTTAAATCCC
TTGGTTACTCTAGGAGGCAATAAAGAAAGTTTTCAACAGCCAGAAGTCAGGCTTTGTCAG
CTGAACTACACAGATATAAAGGATTATTTGGCTCAGCCTGAAAAGATCACCTTGATTTTC
CTTGGAGTAGAACTTGAAATGAAAAAAGAGTTTTTTAATTATGCTGGGGAAATCTCAAAA
GAAGAAGAAGATGGGTTGGTTGCCTGGTTTGCTTTAGGTATAGATACTGTTGCTGCTGAA
GAATTTAAGCAAAGGCATGAAAATTGTTATTTTCTTCATCCACCAATGCCAGCTCTTCTG
CAATTGAAAGAAAAAGAAGCTGGGGTTGTAGCTCAAGCAAGATCTGTTCTCGCTTGGCAC
AGTCGGTATAAGTTCTGCCCAACCTGTGGAAATGCAACTAAAATTGAAGAAGGTGGCTAT
AAAAGAGTATGCTTAAAAGAAGACTGTCCTAGTCTCCATGGTGTTCACAATACATCATAC
CCAAGAGTTGATCCAGTGGTAATCATGCAAGTTATTCATCCCGATGGGACCAAATGTCTT
TTAGGCAGGCAGAAGAGATTTCCTCCGGGCATGTTTACTTGCCTCGCTGGATTTATTGAA
CCTGGGGAGACAATAGAAGACGCTGTTCGGAGAGAAGTAGAAGAGGAAAGTGGAGTCAAA
GTTGGCCATGTTCAGTATGTCTCTTGTCAACCGTGGCCAATGCCCTCTTCCTTAATGATT
GGTTGCTTAGCTGTGGCAGTGTCTACAGAAATTAAAGTTGACAAGAATGAAATAGAGGAT
GCCCGCTGGTTCACTAGAGAACAGGTTGTGGATGTTCTGACCAAAGGCAAGCAGCAGGCA
TTCTTTGTTCCACCGAGCCGAGCTATTGCACATCAGTTAATCAAACACTGGATTGGAATG
AACCCCAATCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 444 |
| Molecular Weight
| 50119.0 |
| Theoretical pI
| 6.69 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal NADH pyrophosphatase NUDT12
MSSVKRSLNQEIISQFHYSAAEGDIAKLTAILSHSPSLLNETSENGWSALICDRSIVNKS
RQTALDIAKFWGYKHIANLLANAKGGKKPWFLTNEVEECENYFSKTLLDRKSEKRNNSDW
LLAKESHPATVYILFSDLNPLVTLGGNKESFQQPEVRLCQLNYTDIKDYLAQPEKITLIF
LGVELEMKKEFFNYAGEISKEEEDGLVAWFALGIDTVAAEEFKQRHENCYFLHPPMPALL
QLKEKEAGVVAQARSVLAWHSRYKFCPTCGNATKIEEGGYKRVCLKEDCPSLHGVHNTSY
PRVDPVVIMQVIHPDGTKCLLGRQKRFPPGMFTCLAGFIEPGETIEDAVRREVEEESGVK
VGHVQYVSCQPWPMPSSLMIGCLAVAVSTEIKVDKNEIEDARWFTREQVVDVLTKGKQQA
FFVPPSRAIAHQLIKHWIGMNPNL
|
| External Links |
|---|
| GenBank ID Protein
| AAI14174.1 |
| UniProtKB/Swiss-Prot ID
| Q29RH3 |
| UniProtKB/Swiss-Prot Entry Name
| NUD12_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114173 |
| GeneCard ID
| NUDT12 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
