| Identification |
|---|
| BMDB Protein ID
| BMDBP00520 |
| Secondary Accession Numbers
| None |
| Name
| Three-prime repair exonuclease 1 |
| Synonyms
|
Not Available
|
| Gene Name
| TREX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 3'-5' exonuclease activity |
| Specific Function
| Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| TREX1 |
| Gene Sequence
|
>948 bp
ATGGGCTCTCGGGCCCTGCCCCCGGGGCCTGTGCAGACCCTCATCTTCCTGGACTTGGAG
GCCACCGGCCTGCCCTTCTCCCAGCCCAAGATCACCGAGCTGTGCCTGCTGGCCGTCCAC
AGATATGCCCTGGAGGGCCTTTCTGCGCCTCAGGGGCCTTCGCCAACGGCACCCGTGCCG
CCCCGGGTGCTGGACAAGCTCTCCCTGTGCGTGGCTCCAGGGAAGGTGTGCAGCCCCGCG
GCCAGCGAAATCACAGGCCTGAGCACCGCCGTGCTGGCTGCACATGGGCGTCGGGCCTTT
GACGCTGACCTGGTCAACCTGATCCGTACCTTCCTACAGCGCCAGCCGCAGCCTTGGTGC
CTCGTGGCCCACAATGGTGACCGCTACGACTTCCCCCTGCTCCGGGCCGAGCTGGCACTG
CTGGGCCTGGCCAGTGCTCTGGACGACGCCTTCTGTGTGGACAGCATCGCTGCCCTGAAG
GCTCTGGAGCCGACTGGCAGCTCCTCGGAGCACGGCCCAAGGAAGAGCTACAGCCTGGGC
AGCGTCTACACACGCCTGTACGGGCAGGCCCCGCCAGACTCGCACACCGCCGAGGGGGAC
GTGCTCGCCCTGCTGAGCGTCTGTCAGTGGAGGCCGCGGGCCCTGCTACGGTGGGTGGAT
GCTCACGCCAAGCCCTTCAGCACCGTCAAGCCAATGTACGTGATCACAACCTCTACTGGA
ACCAACCCAAGGCCATCTGCTGTCACAGCCACTGTGCCCCTGGCCAGAGCCAGTGACACC
GGCCCCAACCTTCGTGGTGACAGGAGCCCCAAGCCAGCTCCTTCCCCAAAGATGTGCCCT
GGAGCCCCACCCGGGGAAGGGCTGCTGGCCCCCCTGGGTCTGCTGGCCTTCCTGACTTTG
GCGGTAGCCATGCTGTATGGGCTGTCCCTGGCCATGCCCGGGCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 315 |
| Molecular Weight
| 33132.0 |
| Theoretical pI
| 8.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Three prime repair exonuclease 1
MGSRALPPGPVQTLIFLDLEATGLPFSQPKITELCLLAVHRYALEGLSAPQGPSPTAPVP
PRVLDKLSLCVAPGKVCSPAASEITGLSTAVLAAHGRRAFDADLVNLIRTFLQRQPQPWC
LVAHNGDRYDFPLLRAELALLGLASALDDAFCVDSIAALKALEPTGSSSEHGPRKSYSLG
SVYTRLYGQAPPDSHTAEGDVLALLSVCQWRPRALLRWVDAHAKPFSTVKPMYVITTSTG
TNPRPSAVTATVPLARASDTGPNLRGDRSPKPAPSPKMCPGAPPGEGLLAPLGLLAFLTL
AVAMLYGLSLAMPGQ
|
| External Links |
|---|
| GenBank ID Protein
| AAK07622.1 |
| UniProtKB/Swiss-Prot ID
| Q9BG99 |
| UniProtKB/Swiss-Prot Entry Name
| TREX1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF319575 |
| GeneCard ID
| TREX1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
