| Identification |
|---|
| BMDB Protein ID
| BMDBP00524 |
| Secondary Accession Numbers
| None |
| Name
| Protein phosphatase 1A |
| Synonyms
|
Not Available
|
| Gene Name
| PPM1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| PPM1A |
| Gene Sequence
|
>1149 bp
ATGGGAGCATTTTTAGACAAACCAAAGATGGAAAAACATAATGCCCAGGGGCAGGGTAAT
GGGTTGCGATATGGGCTAAGCAGCATGCAAGGCTGGCGAGTTGAAATGGAGGATGCACAT
ACTGCTGTGATCGGTCTGCCAAGTGGACTTGAAACATGGTCATTCTTTGCTGTGTATGAT
GGGCATGCTGGTTCTCAGGTTGCCAAATACTGCTGTGAGCATTTGTTAGATCACATCACC
AATAACCAGGATTTTAAAGGGTCTGCAGGAGCACCTTCTGTGGAAAATGTAAAGAATGGA
ATCAGAACAGGCTTCCTGGAGATTGATGAACATATGAGAGTTATGTCAGAGAAGAAACAT
GGTGCTGATAGGAGTGGGTCAACAGCTGTGGGTGTCTTAATTTCTCCTCAACACACGTAT
TTCATTAACTGTGGAGACTCAAGAGGTTTACTTTGTAGGAACAGGAAAGTTTACTTCTTC
ACACAAGATCACAAACCAAGTAATCCGCTGGAAAAAGAACGAATTCAGAATGCAGGTGGT
TCTGTAATGATTCAGCGTGTGAATGGCTCTCTGGCTGTGTCGAGGGCCCTTGGGGACTTT
GATTACAAATGTGTCCATGGAAAAGGTCCTACAGAGCAGCTTGTTTCACCAGAGCCTGAA
GTCCATGATATTGAAAGATCTGAAGAAGATGATCAATTCATTATTCTTGCATGTGATGGT
ATTTGGGATGTCATGGGAAATGAAGAGCTCTGTGATTTTGTAAGATCCAGACTTGAAGTC
ACTGATGACCTTGAGAAAGTTTGCAATGAAGTAGTCGACACCTGTTTGTATAAGGGAAGT
CGAGACAACATGAGTGTGATATTGATCTGTTTTCCAAATGCACCCAAAGTATCGCCAGAA
GCAGTGAAGAAGGAGGAAGAGTTGGACAAATACCTGGAAAGCAGAGTAGAAGAAATCATA
AAGAAGCAGGGGGAAGGCGTCCCTGACTTAGTCCATGTGATGCGCACATTAGCGAGTGAG
AACATACCCAGCCTCCCACCAGGGGGTGAACTGGCAAGCAAGCGGAATGTAATTGAAGCC
GTTTACAATAGACTGAATCCATACAAAAATGATGACACCGACTCTACATCAACTGATGAT
ATGTGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 382 |
| Molecular Weight
| 42530.0 |
| Theoretical pI
| 4.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase 1A
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLETWSFFAVYD
GHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKH
GADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVYFFTQDHKPSNPLEKERIQNAGG
SVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDG
IWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSPE
AVKKEEELDKYLESRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEA
VYNRLNPYKNDDTDSTSTDDMW
|
| External Links |
|---|
| GenBank ID Protein
| CAA06554.1 |
| UniProtKB/Swiss-Prot ID
| O62829 |
| UniProtKB/Swiss-Prot Entry Name
| PPM1A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ005457 |
| GeneCard ID
| PPM1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
