| Identification |
|---|
| BMDB Protein ID
| BMDBP00547 |
| Secondary Accession Numbers
| None |
| Name
| Methionine-R-sulfoxide reductase B1 |
| Synonyms
|
Not Available
|
| Gene Name
| MSRB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| MSRB1 |
| Gene Sequence
|
>285 bp
ATGTCGTTCTGCAGCTTCTTCGGAGGCGAGATTTTCCAGAACCACTTTGAGCCGGGTATC
TACGTGTGTGCCAAGTGTGGCTATGAGCTCTTCTCCAGCCGCTCCAAGTACGCACACTCA
TCCCCATGGCCGGCGTTCACTGAGACCATCCATGCTGACAGTGTGGCCAAGCGGCCAGAG
CACAATCGGCCTGGAGCCATAAAGGTATCCTGTGGCAGGTGTGGCAACGGGCTGGGCCAT
GAGTTCCTGAACGATGGCCCCAAGCGCGGACAGTCCCGCTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 116 |
| Molecular Weight
| 12833.0 |
| Theoretical pI
| 8.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionine-R-sulfoxide reductase B1
MSFCSFFGGEIFQNHFEPGIYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPE
HNRPGAIKVSCGRCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKAEETSASQGQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI05189.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHL9 |
| UniProtKB/Swiss-Prot Entry Name
| MSRB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105188 |
| GeneCard ID
| MSRB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
