1.0 2018-05-07 22:22:53 UTC 2020-05-20 21:10:53 UTC BMDBP00548 Enzyme DIO3 Involved in selenium binding Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. BMDB0000248 Thyroxine BMDB0000265 Liothyronine BMDB0001349 Selenium BMDB0003288 Selenocysteine BMDB0012238 Iodide 21 >837 bp ATGCTGCGCTCCCTGCTGCTTCACTCCCTGAGGCTCTGCTCCCAGACGGCCTCGTGCCTC GTGCTCTTCCCGCGCTTCCTGGGCACGGCCTTCATGCTCTGGCTGCTAGACTTCCTGTGC ATCCGTAAGCATTTACTGGGCCGTCGACGCCGGGGTCAGCCGGAAATCGAAGTGGAGCTC AACAGCGATGGCGAGGAGGTGCCCCCCGACGACCCGCCTGTCTGCGTGTCCGACGACAAC CGCCTGTGCACCTTGGCGTCGCTGAGGGCCGTCTGGCACGGCCAGAAGTTGGATTTCTTC AAGCAGGCGCATGAAGGCGGGCCGGCGCCCAACTCTGAGGTGGTCCTGCCCGACGGCTTC CAGAACCAGCACATCCTCGACTACGCCCGAGGAAACCGTCCGCTGGTGCTCAACTTCGGC AGCTGCACCTGACCACCGTTCATGGCGCGCATGAGCGCCTTCCAGCGCCTGGTCACCAAG TATCAGCGCGACGTCGACTTCCTCATCATCTACATCGAGGAAGCTCACCCTTCCGACGGC TGGGTCACCACAGACTCTCCCTACAGCATCCCGCAGCACCGAAGCCTGGAGGACCGGGTC AGCGCCGCGCGCGTACTGCAGCAAGGGGCTCCAGAATGCGCTCTCGTGCTCGACACGATG ACCAACTCCAGCAGCTCGGCCTACGGTGCCTACTTCGAGCGCCTCTACATCATCCAGAGT GGCACCATTATGTACCAGGGCGGCCGCGGCCCCGACGGCTACCAGGTCTCCGAGGTGCGC ACCTGGCTGGAGCGCTATGATGAGCAGCTGCACGGCCCACAGCCCCGTCGAGTGTAA 301 33888.0 6.5 42-64 None >Type III iodothyronine deiodinase MLRSLLLHSLRLCSQTASCLVLFPRFLGTAFMLWLLDFLCIRKHLLGRRRRGQPEIEVEL NSDGEEVPPDDPPVCVSDDNRLCTLASLRAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGF QNQHILDYARGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDG WVTTDSPYSIPQHRSLEDRVSAARVLQQGAPECALVLDTMTNSSSSAYGAYFERLYIIQS GTIMYQGGRGPDGYQVSEVRTWLERYDEQLHGPQPRRV AAW51124.1 Q5I3B1 IOD3_BOVIN AAFC03027682 DIO3