1.0 2018-05-07 22:22:56 UTC 2020-05-20 21:10:27 UTC BMDBP00558 Enzyme ARG2 Amino acid transport and metabolism May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. L-ornithine and urea from L-arginine: step 1/1 Nitrogen metabolism Urea Cycle SMP0087224 BMDB0000214 Ornithine BMDB0000294 Urea BMDB0000517 L-Arginine BMDB0001333 Manganese 10 >1065 bp ATGTCCCTGAGGAGCCACCTCTCGCGTCTCCTCCGGACGCAAGTGCACTCCGTCCGGAAG AAGTCTGTCCACTCCGTGGCTGTCATTGGAGCCCCATTCTCCCAGGGACAGAAAAGAAAA GGAGTGGAATATGGTCCTGCTGCTGTAAGANAAGCTGGCTTGATGAAAAGGCTCTCGGAT CTGGGCTGCCACCTTAAAGACTTCGGAGATTTGAATTTTACTCCAGTTCCCAAAGATGAT CTCTATAACAACTTGATAGTGAATCCTCGCTCAGTGGGCCTGGCCAACCAGGAACTAGCG GAGGTGGTTAGCCGAGCTGTGTCAGGTGGCTACAGCTGTGTCACGGTGGGAGGAGACCAC AGCCTGGCAATCGGTACCATCAGTGGCCACGCCCGACACTGCCCAGACCTTGGTGTGATC TGGGTTGATGCCCATGCTGACATCAATACACCCCTCACCACTTCATCTGGAAATCTACAT GGACAGCCAGTTTCGTTTCTCCTCAGAGAACTACAGGACAAGGTACCACAGCTCCCAGGA TTTTCCTGGATCAAACCTTGTATCTCTTCTCCAAGTATTGTATATATTGGACTAAGAGAC GTGGACCCTCCTGAACATTTTATTTTAAAGAATTATGATATCCAGTATTTTTCCATGAGA GACATAGATCGACTTGGTATCCAGAAGGTCATGGAACAGACATTCGATCTGCTGATTGGC AAAAGACAAAGGCCAATCCATCTGAGTTTCGATATTGATGCATTTGACCCTACACTGGCT CCAGCCACAGGAACCCCTGTTGTAGGGGGACTGACCTATCGAGAAGGCATATATATTACT GAGGAAATACACAGTACAGGGTTGCTCTCGGCCCTGGACCTCGTTGAAGTCAATCCTCGG TTGGCCGTGTCAGAGGAGGAGGCCAAGGCTACAGCCAGCCTGGCAGTGGACGTCATTGCT TCGAGTTTCGGGCAGACGAGGGAGGGAGGGCATATTGTCTACGACCAACTTCCAACTCCC AGCTCACCAGATGAATCAGAGAGTGAAGAACGTGTAAGAATTTAG 354 38616.0 6.45 None >Arginase-2, mitochondrial MSLRSHLSRLLRTQVHSVRKKSVHSVAVIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD LGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVGGDH SLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG FSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDLLIG KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTGLLSALDLVEVNPR LAVSEEEAKATASLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESESEERVRI AAX46433.1 Q58DL1 ARGI2_BOVIN 1PQ3 BT021586 ARG2