| Identification |
|---|
| BMDB Protein ID
| BMDBP00561 |
| Secondary Accession Numbers
| None |
| Name
| Histidine decarboxylase |
| Synonyms
|
Not Available
|
| Gene Name
| HDC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the biosynthesis of histamine from histidine. |
| Pathways
|
- Amine and polyamine biosynthesis
- Histamine biosynthesis
- Histamine from L-histidine: step 1/1
- Histidine Metabolism
|
| Reactions
|
| L-Histidine → Histamine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| HDC |
| Gene Sequence
|
>1977 bp
ATGATGGAGCCTGAAGAGTACAGAGAGAGAGGAAAGGAGATGGTGGACTACATCTGCCAG
TACCTGACCACTGTGCGGGAGCGGCGGGTGACTCCAGACGTGAGGCCTGGCTACCTGCGA
GCTCAGCTGCCTGAGAGTGCGCCCATGGAGCCCGACAGCTGGGACAGCATCTTTGGGGAC
ATTGAGCGAATCATCATGCCTGGGGTGGTGCACTGGCAAAGCCCCCATATGCATGCCTAC
TACCCAGCTCTCACCTCTTGGCCATCACTGCTGGGAGACATGCTGGCTGATGCCATCAAC
TGCTTGGGATTCACCTGGGCTTCCAGTCCTGCGTGCACGGAGCTGGAGATGAACGTCATG
GACTGGCTGGCAAAAATGCTGGGACTCCCGGAGCACTTCCTGCACCACCACCCTGGCAGC
CAGGGGGGAGGCGTCTTGCAGAGCACAGTCAGCGAGTCCACCTTGATCGCCTTGCTGGCA
GCAAGGAAGAACAAAATCCTGGAAATGAAAGCCTCTGAGCCTGAGGCGGATGAGTCCTTC
CTGAACGCCCGGCTTGTGGCCTATGCCTCCGACCAGGCCCACTCCTCGGTGGAAAAGGCT
GGTCTGATTTCCCTGGTCAAGATGAAATTTCTGCCTGTGGATGAGAACTTCTCGCTCCGA
GGGGAAGCTCTTCAGAAAGCCATCAAGGAGGACAGGGAAAGGGGCCTGGTGCCCATCTTT
GTCTGTGCAACGCTGGGGACCACTGGGGTCTGTGCATTTGACTGCCTGTCAGAGCTGGGC
CCCATCTGTGCCCGTGAGGGGCTGTGGCTGCACATTGACGCTGCCTACGCAGGCACTGCC
TTCCTGTGCCCCGAGTTCCGGGGCTTTCTGAAGGGCATCGAGTATGCCGATTCCTTCACC
TTTAACCCTTCCAAGTGGATGATGGTGCACTTTGACTGCACCGGCTTCTGGGTCAAGGAC
AAGTACAAGCTGCAGCAGACCTTCAGCGTAGACCCCGTCTACCTCAGGCACGCTGACTCG
GGCGTGGCCACCGACTTCATGCACTGGCAGATCCCCTTGAGCCGACGCTTTCGCTCTATT
AAACTCTGGTTCGTGATTCGGTCCTTTGGGGTGAAGAATCTTCAAGCGCATGTCAGACAT
GGCACGGAAATGGCTAAGTATTTTGAATCTCTGGTCAGAAATGACCCTTTCTTTGAAATT
CCTGCCAAGAGGCACCTTGGCCTGGTGGTTTTTCGTCTCAAGGGTCCTAACTGCCTCACA
GAAAGCGTGTTAAAGGAAATAGCTAAAGCTGGCCGTCTCTTCCTTATTCCAGCCACTATC
CAGGACAAGTTGATCATCCGTTTCACTGTGACATCCCAGTTCACCACCAGGGATGACATC
CTGAGAGACTGGAATCTCATTCAGGATGCTGCCACTCTCATCCTGAGTCAGCATTGTACT
TCCCAACCCAGCCCTCAGGGAGCGAACCTCATCCTCCAAACCAGGGGCCCCAGAGCCTTG
GCCAAGGAGATGTCCTTTCCCTCTGTCAACGGGGCAGGCGATGACCCAGCCCATTCCAGG
AAGATCGTCATGCAGCCTCCGCGTGTGGGAGCCAGTCCTGTGAGCCGGCATCTTGAAACC
CTGCTGGACCCACTGGATGACTGCTTCTCTGAAGAGGCTCCAGACGTCACTGAGCACAAG
CTGTCCTCCTTTCTGTTCAGTTATTTGTCTGTGCAGAACAAGAGGAAGGCAGTACGTTCC
CTCAGTTGCAATAGCGTGCCTGTGAGTGCTCAAAAGCAACTGACCACTGAAGGCTCTGTG
AAGAATGGCAGCTCCTCCCGGGTCAGAATCTTTTCTAGGTTCCCAGAAGAGGTGATGATG
CTGAAGAAGAGTGCCTTCAAAAAACTAATCAAGTTCTACAGTGTCCCCAACTTTCCTGAA
TGCAGCTCTCAGTGTGGGCTACAGCTGCCCTGCTGCCCTCTGCAGGCAATGGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 658 |
| Molecular Weight
| 73912.0 |
| Theoretical pI
| 7.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histidine decarboxylase
MMEPEEYRERGKEMVDYICQYLTTVRERRVTPDVRPGYLRAQLPESAPMEPDSWDSIFGD
IERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVM
DWLAKMLGLPEHFLHHHPGSQGGGVLQSTVSESTLIALLAARKNKILEMKASEPEADESF
LNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDENFSLRGEALQKAIKEDRERGLVPIF
VCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFT
FNPSKWMMVHFDCTGFWVKDKYKLQQTFSVDPVYLRHADSGVATDFMHWQIPLSRRFRSI
KLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPFFEIPAKRHLGLVVFRLKGPNCLT
ESVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIQDAATLILSQHCT
SQPSPQGANLILQTRGPRALAKEMSFPSVNGAGDDPAHSRKIVMQPPRVGASPVSRHLET
LLDPLDDCFSEEAPDVTEHKLSSFLFSYLSVQNKRKAVRSLSCNSVPVSAQKQLTTEGSV
KNGSSSRVRIFSRFPEEVMMLKKSAFKKLIKFYSVPNFPECSSQCGLQLPCCPLQAMV
|
| External Links |
|---|
| GenBank ID Protein
| AAX08703.1 |
| UniProtKB/Swiss-Prot ID
| Q5EA83 |
| UniProtKB/Swiss-Prot Entry Name
| DCHS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020686 |
| GeneCard ID
| HDC |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
