Showing Protein Bifunctional purine biosynthesis protein PURH (BMDBP00598)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 6 metabolites
Identification
BMDB Protein ID BMDBP00598
Secondary Accession Numbers None
Name Bifunctional purine biosynthesis protein PURH
Synonyms Not Available
Gene Name ATIC
Protein Type Enzyme
Biological Properties
General Function Nucleotide transport and metabolism
Specific Function Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.
Pathways
  • 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.
  • IMP biosynthesis via de novo pathway
  • IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1
  • Purine Metabolism
Reactions
N10-Formyl-THF + AICAR → Tetrahydrofolic acid + Phosphoribosyl formamidocarboxamide details
Inosinic acid + Water → Phosphoribosyl formamidocarboxamide details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus Not Available
SNPs ATIC
Gene Sequence 
>1779 bp
ATGGCACCCGGCCAGCTCGCTTTATTTAGTGTCTCTGACAAAAATGGCCTTGTGGAGTTT
GCCAGGAACTTAGCTTCTGTCGGTTTGAATCTGATCGCCTCTGGAGGGACTGCAAAAGCC
CTCAGAGATGCTGGTTTGGCAGTCAGAGATGTCTCTGAGCTAACTGGATTTCCTGAAATG
CTAGGGGGGCGTGTAAAAACCTTGCATCCTGCAGTCCATGCTGGAATCTTGGCTCGTGAT
ATCCCAGAAGATAGTGCTGACATGGCCAAACTTGATTTCAATCTTATAAGAGTTGTTGTT
TGTAATCTGTATCCCTTTGGGAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAAGAGGCT
GTTGAACATATTGATATTGGAGGAGTGACTCTGCTGAGAGCAGCAGCCAAAAACCACGCT
CGAGTGACAGTAGTATGTGAGCCGGAGGACTATGCAGCTGTAGCCTCAGAGATGCAGGAT
TCTGACAGCAAAGACACGTCCTTGGAGACAAGACGCCAGTTAGCCTTGAAGGCTTTTACT
CATACAGCACAGTATGATGAAGCAATTTCAGATTACTTCAGGAAAGAGTACAGTAAAGGA
GTATCTCAGATGCCCCTGAGGTATGGAATGAACCCTCATCAGACTCCTGCCCAGCTGTAT
ACGCTGAAGCCCAAGCTCCCTATCACAGTTCTGAATGGAGCCCCTGGATTTATAAACTTG
TGTGATGCTTTGAATGCCTGGCAGCTGGTGAAGGAACTCAAAGAAGCTTTAGGCCTTCCA
GCTGCTGCGTCTTTCAAACATGTTAGCCCAGCAGGTGCTGCTGTTGGAATTCCACTCAGT
GAAGACGAAGCCAACGTCTGCATGGTCTATGATCTGTACAAAACCCTCACACCCGTAGCC
ACTGCATACGCAAGAGCAAGAGGGGCTGATAGGATGTCTTCCTTTGGTGACTTTGTTGCA
TTATCTGATGTTTGTGATGTCCCTACTGCCAAGATTATCTCCAGAGAGGTATCTGATGGT
ATTATTGCCCCGGGATATGAAAATGAAGCTTTGAAAATACTTTCCAAAAAGAAAAATGGT
AATTACTGTGTTCTTCAGATGGACCAGTCTTATATTCCAGACGAAAATGAAGTTCGAACT
CTCTTTGGTCTTCGTTTAAGCCAGAAGAGAAATAATAGTGTTGTCAACAGGTCACTGTTT
AGCAACATTGTTACCAAGAATAAAGATTTGCCAGAATCTGCGCTCAGGGACCTCATCGTG
GCCACCATTGCTGTCAAGTACACCCAGTCGAACTCCGTGTGCTATGCCAAGAATGGGCAG
GTTATTGGCATCGGAGCAGGACAGCAGTCTCGTATACACTGCACACGCCTTGCAGGTGAT
AAGGCAAACTGTTGGTGGCTTAGACATCACCCCCAAGTGCTTTCCATGAAGTTTAAAACT
GGCGTGAAGAGAGCGGAAATCTCCAATGCCATCGATCAGTATGTTACTGGAACTATCGGC
GAGGGTGAAGATTTGATCAAGTGGAAGGCACTGTTTGAGGAGGTCCCTGAGTTGTTAACC
GAGACAGAAAAAAAGGAATGGATTGACAAACTTAATGAAGTTTCCATCAGCTCTGATGCC
TTCTTTCCTTTCCGGGACAATGTAGACAGAGCTAAAAGGAGTGGCGTGGCCTACATCGCT
GCCCCTTCCGGTTCTGCCGCTGACAAAGTTGTGATCGAGGCTTGCGATGAGCTGGGAATA
ATCCTTGCTCATACGAATCTCCGGCTCTTCCATCACTGA
Protein Properties
Number of Residues 592
Molecular Weight 64483.0
Theoretical pI 6.83
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Bifunctional purine biosynthesis protein PURH
MAPGQLALFSVSDKNGLVEFARNLASVGLNLIASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARDIPEDSADMAKLDFNLIRVVVCNLYPFGKTVASPGVTVEEA
VEHIDIGGVTLLRAAAKNHARVTVVCEPEDYAAVASEMQDSDSKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKEYSKGVSQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGLPAAASFKHVSPAGAAVGIPLSEDEANVCMVYDLYKTLTPVA
TAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYENEALKILSKKKNG
NYCVLQMDQSYIPDENEVRTLFGLRLSQKRNNSVVNRSLFSNIVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANCWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEGEDLIKWKALFEEVPELLTETEKKEWIDKLNEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
GenBank ID Protein AAI20132.1
UniProtKB/Swiss-Prot ID Q0VCK0
UniProtKB/Swiss-Prot Entry Name PUR9_BOVIN
PDB IDs
GenBank Gene ID BC120131
GeneCard ID ATIC
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available