| Identification |
|---|
| BMDB Protein ID
| BMDBP00600 |
| Secondary Accession Numbers
| None |
| Name
| Trifunctional purine biosynthetic protein adenosine-3 |
| Synonyms
|
Not Available
|
| Gene Name
| GART |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Not Available |
| Pathways
|
- 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.
- IMP biosynthesis via de novo pathway
- N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.
- N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1
- PATHWAY: Purine metabolism
- Purine Metabolism
|
| Reactions
|
| Adenosine triphosphate + 5-Phosphoribosylamine + Glycine → ADP + Hydrogen phosphate + Glycineamideribotide |
details
|
| N10-Formyl-THF + Glycineamideribotide → Tetrahydrofolic acid + 5'-Phosphoribosyl-N-formylglycinamide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q12.1-q12.2 |
| SNPs
| GART |
| Gene Sequence
|
>3033 bp
ATGGCAGCCCGAGTACTTGTCATTGGCAATGGAGGACGAGAACACACGCTGGCCTGGAAA
CTTGCACAGTCTACTCATGTCAAACAAGTGTTGGTTACCCCAGGAAATGCAGGCACTGCC
TGCTCTGAGAAGATTTCAAATACTGACATCTCAATCAGTGATCATACTGCCCTTGCGCAG
TTCTGCAAAGATGAGAAAATTGAATTCGTAGTTGTTGGACCAGAGGCACCTCTAGCTGCT
GGAATTGTTGGGAACCTGAACTCTGTGGGAGTTCGGTGCTTTGGCCCCACAGCACAAGCA
GCTCAGTTAGAGTCCAGCAAGAGATTTGCCAAAGAGTTTATGGACCGACATGGAATCTCA
ACTGCAAGATGGAGAGCTTTCACTAAACCTAAAGAAGCCTGTGACTTCATTATGAGTGCA
GACTTCCCTGCTTTGGTTGTGAAGGCCAGTGGTCTTGCAGCTGGGAAAGGGGTAATTGTT
GCCAAGAGCAAAGAGGAGGCCTGTGAAGCTGTCAGAGAGATTATGCAGGGTAAAGCTTTC
GGAGAAGCAGGAGAAACAGTTGTCATTGAAGAACTTCTTGAAGGAGAAGAGGTGTCTTGT
CTGTGCTTCACTGATGGACGGACTGTGGCCCCCATGCCCCCAGCACAGGACCATAAGCGA
TTGCTGGAGGGCGATGAGGGCCCCAACACGGGAGGAATGGGAGCCTATTGTCCAGCCCCT
CAGGTTTCTAAGGATTTGTTGCTAAAAATTAAAAATAATATTCTTCAGAGGACAGTGGAT
GGCATGCAGGAGGAGGGTATGCCATACACAGGTGTCCTCTATGCTGGTATAATGCTGACC
AAGAACGGCCCCAAAGTTCTGGAATTTAATTGCCGTTTCGGTGATCCAGAGTGCCAAGTG
ATCCTCCCACTTCTTAAAAGTGATCTTTATGAAGTGATTCAGTCTATCTTAGATGGCTTG
CTCTGCACTTCTCTGCCTGTTTGGCTGGACAACTGTGCTGCCGTAACTGTGGTCATGGCA
AGTAAAGGTTATCCAGGAGACTACACCAAGGGTGTAGAGATAACAGGGTTTCCTGAGGCT
CAGGCTTTAGGACTGGAGGTGTTCCAAGCAGGCACTGCCCTAAAAGATGGCAAGGTGGTG
ACTAACGGGGGTAGGGTCCTTACTGTCACGGCCATCAGGGAAAATCTCATCTCAGCTCTT
GAAGAAGCCAGGAAAGGACTTGCCGCCATAAAGTTTGAGGGAGCTGTTTATAGGAAAGAC
ATCGGCTTTCGAGCCATAGCTTTCCTCCAGCAGCCCAGGGGCCTGACTTACAAGGAATCT
GGGGTAGACATTGCAGCTGGTAATATGCTGGTCCAGAAAATTAAACCTTTAGCGAAGGCC
ACCTCCAGACCAGGCTGTGATGTTGATCTTGGAGGTTTTGCTGGTCTTTTTGATTTGAAA
GCAGCTGGTTTCACTGATCCTCTTCTGGCTTGTGGAACAGATGGTGTTGGGACGAAACTG
AAGATTGCCCAGCAGTGCAGTAAACATGACACCATTGGTCAGGATTTGGTTGCGATGTGT
GTAAATGACATTCTGGCACAAGGAGCAGAGCCCCTCTTTTTCCTCGATTACTTTTCCTGT
GGAAAACTTGACCTCCGTACTACTGAAGCTGTTATCACTGGGATCGCCAAAGCTTGTAAA
AAGGCTGGATGTGCTCTCCTCGGAGGTGAAACGGCAGAGATGCCTGACATGTACCCTCCT
GGAGAGTATGATCTAGCTGGTTTTGCCGTTGGCGCCATGGAGCGGGATCAGAAACTTCCT
CAACTGGAAAGAATCACGGAAGGAGACGCTGTTATTGGAATCGCTTCATCTGGTCTTCAC
AGCAACGGATTCAGCCTTGTGAGGAAAATTGTAGCAAAATCTTCTCTCGAGTACTCTTCT
CCAGCACCTGGTGGCTGTGGTGACCAGACCTTAGGTGACTTACTTCTAACCCCAACCAAA
ATCTACAGCCGCTCACTGTTACCTGTCCTGCGTTCAGGACGTGTTAAGGCCGTTGCACAT
ATTACTGGTGGAGGATTACTGGAAAACATCCCCAGAGTCCTCCCTCAGAAATTGGGGGTG
AATTTAGATGCCCAGACCTGGAGGGTCCCCAGGATCTTCTCATGGTTACAGCAGGAAGGC
CACCTCTCTGAAGAGGAGATGGCCAGAACATTTAACTGTGGGATTGGGGCTGCCCTCGTG
GTATCAGAGGACCTGGTGAAGCAGACTCTGCAGGATATTGAGCAGCACCAGGAAGAAGCC
TGCGTGATCGGCAGAGTGGTTGCATGTCCCAAGGGTTCTCCTCGTGTGAAAGTCGAGCAT
CTGATTGAAACCATGCAAATAAATGGATCAGTATTGGAGAATGGAACCCTGAGAAATCAT
TTCTCTGTTCAACCAAAAAAGGCAAGAGTAGCTGTCTTAATTTCTGGGACAGGATCAAAC
CTCCAAGCTCTCATAGACAGCACTAGGGAGCCAAGTAGCTTGGCACACATTGTCATTGTG
ATCTCCAACAAAGCTGCAGTGGCTGGGTTAGATAAAGCAGAAAAAGCCGGGATTCCCACG
AGAGTAATTAATCATAAATTATATAAAAATCGTGCAGCATTTGACACTGCAATTGACGAA
GTCCTTGAAGAGTTCTCCACAGACATAGTCTGTCTTGCAGGATTCATGAGAATTTTGTCT
GGCCCCTTCGTCAGAAAATGGAATGGGAAAATGCTCAATATCCACCCATCCTTGCTCCCT
TCGTTTAAGGGTTCAAATGCCCATGAACAAGTCCTGGATGCTGGGGTCACAGTCACCGGG
TGCACCGTGCACTTTGTAGCTGAAGATGTAGATGCCGGTCAAATTATCTTACAGGAAGCC
GTTCCAGTGAAGAGGGGTGACACTGTTGAAACTCTATCTGAGAGAGTAAAATTAGCAGAA
CATAAAATATTTCCCTCAGCCCTCCAGCTGGTGGCCAGTGGAGCTGTACGGCTTGGAGAA
AATGGCAGAATCTGTTGGGTCACAGAGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1010 |
| Molecular Weight
| 107907.0 |
| Theoretical pI
| 6.34 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Trifunctional purine biosynthetic protein adenosine-3
MAARVLVIGNGGREHTLAWKLAQSTHVKQVLVTPGNAGTACSEKISNTDISISDHTALAQ
FCKDEKIEFVVVGPEAPLAAGIVGNLNSVGVRCFGPTAQAAQLESSKRFAKEFMDRHGIS
TARWRAFTKPKEACDFIMSADFPALVVKASGLAAGKGVIVAKSKEEACEAVREIMQGKAF
GEAGETVVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDEGPNTGGMGAYCPAP
QVSKDLLLKIKNNILQRTVDGMQEEGMPYTGVLYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSILDGLLCTSLPVWLDNCAAVTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFQAGTALKDGKVVTNGGRVLTVTAIRENLISALEEARKGLAAIKFEGAVYRKD
IGFRAIAFLQQPRGLTYKESGVDIAAGNMLVQKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFTDPLLACGTDGVGTKLKIAQQCSKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLRTTEAVITGIAKACKKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
QLERITEGDAVIGIASSGLHSNGFSLVRKIVAKSSLEYSSPAPGGCGDQTLGDLLLTPTK
IYSRSLLPVLRSGRVKAVAHITGGGLLENIPRVLPQKLGVNLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSEDLVKQTLQDIEQHQEEACVIGRVVACPKGSPRVKVEH
LIETMQINGSVLENGTLRNHFSVQPKKARVAVLISGTGSNLQALIDSTREPSSLAHIVIV
ISNKAAVAGLDKAEKAGIPTRVINHKLYKNRAAFDTAIDEVLEEFSTDIVCLAGFMRILS
GPFVRKWNGKMLNIHPSLLPSFKGSNAHEQVLDAGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVETLSERVKLAEHKIFPSALQLVASGAVRLGENGRICWVTED
|
| External Links |
|---|
| GenBank ID Protein
| CAG47113.1 |
| UniProtKB/Swiss-Prot ID
| Q59A32 |
| UniProtKB/Swiss-Prot Entry Name
| PUR2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ780930 |
| GeneCard ID
| GART |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
