1.0 2018-05-07 22:23:08 UTC 2020-05-20 21:09:29 UTC BMDBP00602 Enzyme CBR1 Lipid transport and metabolism NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity). Arachidonic Acid Metabolism SMP0087220 Pterine Biosynthesis SMP0087250 BMDB0000125 Glutathione BMDB0000217 NADP BMDB0000221 NADPH BMDB0000902 NAD BMDB0001139 Prostaglandin F2a BMDB0004645 S-Nitrosoglutathione BMDB0001220 Prostaglandin E2 BMDB0000238 Sepiapterin BMDB0002275 7,8-Dihydroneopterin 1 >834 bp ATGTCGTCCTCCAACTGCGTGGCGCTGGTCACCGGGGCCAACAAGGGCATCGGCTTCGTC ATCGTGCGTGACCTGTGCCGGCGGTTCTCGGGCGACGTGGTGCTCACGGCGCGGGACGAG GCGCGGGGTCGGGCGGCCGTGCAGCAGCTGCAGGCTGAGGGCCTGAGCCCCCTTTTCCAC CAGCTGGACATCGACGACCGGCAGAGCATCCGCGCCCTGCGTGACTTCCTGCGCAAGGAG TACGGGGGCCTCGATGTGCTGGTCAACAACGCGGGCATTGCCTTCAAGACTGCTGACACC ACACCATTTCACATTCAAGCAGAGGTGACTATGAAAACAAACTTCTTTGGCACCAGAGAT GTGTGCACGGAGCTCCTGCCTCTAATAAAACCGCAAGGCAGAGTGGTGAATGTATCCAGC TTTGTCAGTGTCAACTCTCTAAAGAAATGCAGCCGTGAACTGCAGCAGAAGTTTCGAAGT GAGACCATCACAGAGGAGGAGCTGGTGGGGCTCATGAACAAGTTTGTGGAAGACACAAAG AACGGGGTGCACAGGAAGGAGGGCTGGCCCGATACCGCATATGGAGTGACGAAAATTGGA GTCACAGTCCTGTCCAGAATCCACGCCAGGAAACTGAGTGAGCAGAGAGGAGGGGACAAG ATCCTCCTGAACGCCTGCTGCCCAGGGTGGGTGAGAACCGACATGGGGGGACCCAAAGCC TCCAAAAGCCCAGAAGAAGGAGCAGAGACCCCCGTGTACTTGGCCCTTCTGCCCTCAGAT GCTGAGGGGCCTCACGGAGAGTTCATTTCTGAGAAAAGAGTTGTGCAATGGTGA 277 30533.0 8.37 None >Carbonyl reductase [NADPH] 1 MSSSNCVALVTGANKGIGFVIVRDLCRRFSGDVVLTARDEARGRAAVQQLQAEGLSPLFH QLDIDDRQSIRALRDFLRKEYGGLDVLVNNAGIAFKTADTTPFHIQAEVTMKTNFFGTRD VCTELLPLIKPQGRVVNVSSFVSVNSLKKCSRELQQKFRSETITEEELVGLMNKFVEDTK NGVHRKEGWPDTAYGVTKIGVTVLSRIHARKLSEQRGGDKILLNACCPGWVRTDMGGPKA SKSPEEGAETPVYLALLPSDAEGPHGEFISEKRVVQW AAI02944.1 Q3SZD7 CBR1_BOVIN BC102943 CBR1