| Identification |
|---|
| BMDB Protein ID
| BMDBP00606 |
| Secondary Accession Numbers
| None |
| Name
| 17-beta-hydroxysteroid dehydrogenase type 6 |
| Synonyms
|
Not Available
|
| Gene Name
| HSD17B6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| HSD17B6 |
| Gene Sequence
|
>954 bp
ATGTGGCTGTACCTGGCAGTCCTCTTGGGCCTGTACTACCTCCTGCGCTGGTTCCGAGAG
AGGCAGGTGGTGAGCCACCTCCAGGACAAGTTTGTCTTCATCACGGGCTGTGACTCGGGC
TTTGGGAACCAGCTGGCCAGGCAGCTGGACCTGCGAGGCTTGAGGGTCCTGGCTGGGTGT
CTGACGGAGCAGGGGGCCGAGCAGCTGAGGAACCAGACATCAGACAGGCTGCAGACAGTG
ATTCTGGACGTCACCAAGACAGAGAGCATCGCTGCGGCCACTGAGTGGGTGAAGGAGTGT
GTTGGGGACAGAGGGCTCTGGGGTCTGGTCAACAATGCAGGCATTTTTCACTCACATGGC
TATGCTGAGTGGATAAAGATTGAGACCTACAGGGATACCCTTAGGGTGAACCTCATTGGT
GTGATAGAGGTGACCCTGAGCATGCTTCCCCTGGTCAGGAAAGCACAGGGGAGAATTGTC
AATGTCTCCAGCATTCTGGGAAGAATTGCTTTCTTTGGAGCAGTCTACAGTTGTTCCAAG
TATGGAGTGGAAGCCTTCTCAGATATTCTGAGGCGTGAGCTTCAACATTTTGGGGTGAAA
GTCAGTATGGTTGAACCTGGCTACTTCAGAACAGCAATGACAGATTGGCAGAAGTTCTCA
GAGATAATGAAACAAATCTGGAAAGAAACCCCTGCGCATATTAAGGAGACCTATGGACAG
AAGTTTTTTGATGCCTATCACGATCTCATGAAACAAGGGCTGCTGAGTTGTAGCACAAAC
CTAAACCTGGTCACCGACTGCATGGAACACGCTCTGACATCCGTGCATCCCCGCACTCGA
TACTCAGCTGGCTGGGATGCTCAGTTTTTCTTTGTCCCTCTATCTTATTTGCCTACATCC
CTGGCAGACTACATATTGACTAGATCTTGGCCCAAACCAGCCCAGGCAGTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 317 |
| Molecular Weight
| 36198.0 |
| Theoretical pI
| 8.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxysteroid 17-beta dehydrogenase 6
MWLYLAVLLGLYYLLRWFRERQVVSHLQDKFVFITGCDSGFGNQLARQLDLRGLRVLAGC
LTEQGAEQLRNQTSDRLQTVILDVTKTESIAAATEWVKECVGDRGLWGLVNNAGIFHSHG
YAEWIKIETYRDTLRVNLIGVIEVTLSMLPLVRKAQGRIVNVSSILGRIAFFGAVYSCSK
YGVEAFSDILRRELQHFGVKVSMVEPGYFRTAMTDWQKFSEIMKQIWKETPAHIKETYGQ
KFFDAYHDLMKQGLLSCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAQFFFVPLSYLPTS
LADYILTRSWPKPAQAV
|
| External Links |
|---|
| GenBank ID Protein
| AAI02627.1 |
| UniProtKB/Swiss-Prot ID
| Q3T001 |
| UniProtKB/Swiss-Prot Entry Name
| H17B6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102626 |
| GeneCard ID
| HSD17B6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
