| Identification |
|---|
| BMDB Protein ID
| BMDBP00608 |
| Secondary Accession Numbers
| None |
| Name
| Transketolase-like protein 2 |
| Synonyms
|
Not Available
|
| Gene Name
| TKTL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| TKTL2 |
| Gene Sequence
|
>1881 bp
ATGGCGGACAGCGCGACACTGGACGCGACCACAGTGCAAGTGCTGCAGGACCTGGCCAAC
CGCCTGCGCGTCCATTCCATCAGGGCTACATGTGCCTCTGGCTCCGGCCACCCCACGTCG
TGCTGCAGTGCGGCAGAGATCGTGTCGGTGCTTTTCTTCCACACGATGAGGTACAGACAG
ACTGAGCCCGCGCACCCCGACAACGACAGATTCGTCCTTTCCAAGGGTCATGCCGCTCCA
CTGCTCTATGCTGCCTGGGTGGAGGCAGGCAGCATCAGTGAACCTGACCTGCTGAACTTG
AGGACAATTCATTGCGACCTTGAGGGACACCCCACCCCCAGGCTGTCGTTTGTGGATGTG
GCGACAGGATCGCTCGGGCAAGGTTTGGGGGCTGCATGTGGAATGGCTTATACTGGCAAG
TACTTGGACAAAGCCAGCTACCGGGTATTCTGCCTCCTGGGCGACGGTGAGTCCTCAGAA
GGCTCCGTCTGGGAAGCTTTGGCTTTTGCTTCCCACTACGGTTTGGACAATCTCGTAGCA
GTGTTCGACGTGAACCGCTTGGGGCAAAGTGGCGTTGCGCCCCTGAAGCACTGCACAGAC
ATCTATCGGAATCGCTGCGAGGCCTTTGGGTGGAATACTTACTTAGTAGATGGCCATGAT
GTGGAGGCGTTGTGCCAGGCTTTTTCTCAAGCTGCTCAAGGGAAGAACAAGCCCACTGCC
ATAATTGCAAAGACCTACAAGGGCCGGGGTATTCCAAATGTTGAGGATGCAGAAAATTGG
CATGGAAAGCCACTGCCAAAAGAAAGAGCAGATGAAATCATTAGACTAATTAAAAGTCAG
ATAAAGACCAACAGGAATCTCCTACCAAAACCTCCTGTTGAAGGCTCACCTCCAGTCAGC
ATCACAAATATAAAAATGACCTGTTTGCCTGATTATAAAGTTGGTGACAAGGTAGCTACT
CAGAAAGCATATGGTTTGGCTCTGGCTAAACTCGGCCTTGCAAATGAAAGAGTTGTTGTC
CTGGATGGTGACCCAAAGAACTCCACCTTTTTTGAAATATTCAAGAAAGAACATCCTGAG
CGTTTTATTGAGTGTTTTGCTGCGGAACAAAACATGGTGAGTGTGGCACTGGGCTGTGCC
ACACGTGGTCGAACCATTACTTTTGTTACTACTTTAGGTGCCTTTTTGACTAGAGCATTT
GATCAGATCCGGATGGGAGCCATATCTCAAAGTAATATAAATCTTATTGGTTCTCACTGT
GGGGTGTCTGTTGGTGAAGATGGCCCTTCCCAGATGGCTTTGGAAGATCTAGCCATGTTC
CGGAGCATTCCCAATTGCACTGTTTTCCTCCCAAGTGATGCTGTCTCGACAGAGCATGCT
GTTTATCTGGCTGCCAATAGCGAAGGAATGTGCTTCATTCGGACCAACCGATCAGAAACT
GCAGTTATTTATACCCCACAAGAACATTTTGAGATTGGAAGGGCCAAGGTCATCCGCCAC
AGTAATAATGACAAAGTCACAGTAATTGGAGCTGGAGTTACTCTGCATGAAGCCTTAGCA
GCTGCTGATGCTCTTTCTCAGCAAGATATTTCTATCTGTGTTATTGACCCATTTACCATT
AAACCCCTGGATGCTGCCACCATCATCTCCTGTGCAAAAGCTACTGATGGCCGGGTTGTC
ACAGTGGAAGATCATTACCAGGAAGGTGGCATTGGCGAAGCCGTGTGTGCAGCAGTGTCT
GGGGAGCCTGCCATCCATGTTCATCAGCTATCGGTGTCAGGAGTGTCTGAAAGAAACAGG
AAACCTAGTGAATTACTGAGTATATTTGGTGTCAGTGCAAGACACATCATAGCAGCTGTG
AAATATACTTTAATGAACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 626 |
| Molecular Weight
| 67501.0 |
| Theoretical pI
| 6.62 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transketolase-like protein 2
MADSATLDATTVQVLQDLANRLRVHSIRATCASGSGHPTSCCSAAEIVSVLFFHTMRYRQ
TEPAHPDNDRFVLSKGHAAPLLYAAWVEAGSISEPDLLNLRTIHCDLEGHPTPRLSFVDV
ATGSLGQGLGAACGMAYTGKYLDKASYRVFCLLGDGESSEGSVWEALAFASHYGLDNLVA
VFDVNRLGQSGVAPLKHCTDIYRNRCEAFGWNTYLVDGHDVEALCQAFSQAAQGKNKPTA
IIAKTYKGRGIPNVEDAENWHGKPLPKERADEIIRLIKSQIKTNRNLLPKPPVEGSPPVS
ITNIKMTCLPDYKVGDKVATQKAYGLALAKLGLANERVVVLDGDPKNSTFFEIFKKEHPE
RFIECFAAEQNMVSVALGCATRGRTITFVTTLGAFLTRAFDQIRMGAISQSNINLIGSHC
GVSVGEDGPSQMALEDLAMFRSIPNCTVFLPSDAVSTEHAVYLAANSEGMCFIRTNRSET
AVIYTPQEHFEIGRAKVIRHSNNDKVTVIGAGVTLHEALAAADALSQQDISICVIDPFTI
KPLDAATIISCAKATDGRVVTVEDHYQEGGIGEAVCAAVSGEPAIHVHQLSVSGVSERNR
KPSELLSIFGVSARHIIAAVKYTLMN
|
| External Links |
|---|
| GenBank ID Protein
| AAI11321.1 |
| UniProtKB/Swiss-Prot ID
| Q2NKZ4 |
| UniProtKB/Swiss-Prot Entry Name
| TKTL2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111320 |
| GeneCard ID
| TKTL2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
