| Identification |
|---|
| BMDB Protein ID
| BMDBP00610 |
| Secondary Accession Numbers
| None |
| Name
| Leukotriene A-4 hydrolase |
| Synonyms
|
Not Available
|
| Gene Name
| LTA4H |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity). |
| Pathways
|
- Arachidonic Acid Metabolism
- Leukotriene B4 biosynthesis
- Lipid metabolism
|
| Reactions
|
| Leukotriene A4 + Water → 6-trans-Leukotriene B4 |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| LTA4H |
| Gene Sequence
|
>1836 bp
ATGCCCGAGGTAGTGGATACGTGCTCCTTGGCCTCCCCGGCGTCCGTCTGCCAGACCAAA
CACCTGCACCTGCGTTGCAGCATCGACTTTACTCGCCGGGTACTGAGCGGGACCGCCGCG
CTCACCATCCAGTCCCAGGAGGACAATCTGCGCAGCCTGATTCTGGATACAAAGGACCTC
ACAATAGAAAAAGTGGTCATCAATGGACAAGAAGTCAAATATACTCTTGGAGAAAGACAA
AGTTACAAAGGATCACCAATCGAAATCTCTCTTCCTATTGCTCTATGCAAAAATCAAGAA
ATTGTTATAGAGATTTCTTTCGAGACATCTCCAAAATCTTCTGCTCTTCAGTGGCTCACT
CCTGAACAAACTTCTGGGAAAGAGCACCCCTATCTCTTTAGTCAGTGCCAGGCTATCCAC
TGTAGAGCTATTCTTCCTTGCCAGGACACTCCTTCCGTGAAATTAACCTACAGCGCAGAG
GTGTCTGTCCCCAAAGAACTGGTGGCACTTATGAGTGCCATTCGTGACGGAGAAGCACCT
GACCCAGAAGACCCGAACAGGAAAATTTACAGATTCAGCCAAAAAGTTCCAATCCCCTGC
TACCTGATTGCTTTGGTTGTTGGAGCTTTAGAAAGCAGACAGATTGGCCCAAGGACATTG
GTATGGTCCGAGAAAGAGCAGGTGGAAAAGTCTGCTTACGAATTTTCTGAGACTGAATCT
ATGCTTAAAATTGCAGAAGATCTGGGAGGCCCATATATTTGGGGGCAGTATGACCTATTG
GTCCTGCCGCCATCCTTTCCCTATGGCGGCATGGAGAACCCTTGCCTCACTTTTGTAACT
CCTACTCTGCTGGCTGGTGACAAGTCACTCTCCAATGTTATAGCACATGAAATATCTCAT
AGTTGGACAGGAAATCTAGTGACCAACAAAACTTGGGATCACTTTTGGTTAAATGAAGGA
CATACCGTATACTTGGAACGCCACATTTGTGGACGACTGTTTGGTGAAAAGTTTAGACAT
TTTCACGCTCTGGGCGGATGGGGAGAACTCCAGAATTCGATAAAGACTTTTGGGGAGACC
CATCCTTTCACCAAACTCGTGGTTGACCTGACGAACACAGACCCTGACGTGGCATATTCT
TCAGTTCCCTATGAGAAGGGCTTTGCTTTACTCTTTTACCTTGAACAGCTTCTTGGAGGA
CCAGAGGTTTTCCTAGGATTCTTAAAGGCTTATGTTGAGAAATTTTCCTACAAGAGCATA
ACTACTGATAACTGGAAGGATTTCTTGTATTCCCACTTTAAAGATAAGGTTGATATTCTC
AATCAAGTGGATTGGAACACCTGGCTGTACTCTCCTGGACTGCCCCCTGTAAAACCCAAT
TATGATATGACCCTGACAAATGCTTGCATTTCCTTGAGTCAAAGATGGATCACTGCCAAA
GATGATGATTTAAATTCATTCAGCTCAGCAGACCTAAAAGACTTCTCTTCCCATCAAGTG
AATGAATTTTTAGCACAGATGCTCCAGAATGCACCTCTTCCATTGGGGCACATAAAGCGA
ATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGTTA
CGACTCTGCATTCAATCGAAATGGGAGGAAGCAATTCCTTTGGCTCTAAAAATGGCAACT
GAACAAGGAAGGATGAAGTTTACACGGCCCTTATTCAAGGACCTTGCTGCCTTTGACAAA
TCCCATGATCAAGCCATCCGTACCTACAAGGAGCACAAGGCATCCATGCACCCTGTGACT
GCCATGCTTGTGGGGAAAGATTTAAAAGTGGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 611 |
| Molecular Weight
| 69306.0 |
| Theoretical pI
| 6.33 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Leukotriene A-4 hydrolase
MPEVVDTCSLASPASVCQTKHLHLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAP
DPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNSIKTFGET
HPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDNWKDFLYSHFKDKVDILNQVDWNTWLYSPGLPPVKPNYDMTLTNACISLSQRWITAK
DDDLNSFSSADLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVT
AMLVGKDLKVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI02853.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZH7 |
| UniProtKB/Swiss-Prot Entry Name
| LKHA4_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102852 |
| GeneCard ID
| LTA4H |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
