1.0 2018-05-07 22:23:12 UTC 2020-05-20 21:07:48 UTC BMDBP00615 BMDBP03024 Enzyme PC Involved in ATP binding Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity). Carbohydrate biosynthesis Gluconeogenesis SMP0087223 BMDB0000030 Biotin BMDB0000223 Oxalacetic acid BMDB0000243 Pyruvic acid BMDB0001333 Manganese BMDB0001341 ADP BMDB0000538 Adenosine triphosphate BMDB0000595 Hydrogen carbonate BMDB0000973 Hydrogen phosphate BMDB0001493 3-Methylcrotonyl-CoA BMDB0001057 3-Methylglutaconyl-CoA BMDB0001275 Propionyl-CoA BMDB0002310 S-Methylmalonyl-CoA BMDB0001362 Hydrogen 29 >3537 bp ATGCTGAAGTTTCAGACTGTCCGGGGGAGCCTGAGGCTCCTGGCTATCCGCCGGACCTCC ACCGCAACCGCTGCCTCTCCCAATGTCCGGCGCCTGGAGTACAAGCCCATCAAGAAGGTC ATGGTGGCCAACAGAGGCGAGATCGCCATCCGTGTGTTCCGGGCCTGCACGGAGCTGGGC ATCCGCACGGTGGCTGTCTACTCGGAGCAGGACACGGGCCAAATGCACCGACAGAAAGCT GACGAAGCCTACCTCATCGGCCGGGGTCTTGCCCCGGTGCAGGCCTATCTGCACATTCCA GACATCATTAAGGTCGCCAAGGAGAACAACGTGGACGCTGTGCACCCGGGCTACGGGTTC CTGTCGGAGCGGGCCGACTTTGCCCAGGCCTGCCAGGATGCTGGGGTCCGGTTCATTGGG CCAAGCCCCGAGGTGGTCCGCAAGATAGGTGACAAGGTGGAGGCCCGGACCATCGCCATC GCCGCAGATGTGCCCGTGGTGCCCGGCACGAATGCCCCCATCACTTCCCTGCACGAGGCC CACGAGTTCTCCAACACCTACGGCTTCCCCATCATCTTCAAGGCCGCCTACGGGGGCGGG GGCCGCGGCATGAGGGTCGTGCACAGCTACGAGGAGCTGGAGGAGAACTACACCCGGGCC TACTCGGAGGCTCTGGCCGCCTTCGGGAACGGGGCGCTGTTCGTGGAGAAGTTCATCGAG AAGCCACGCCACATCGAGGTGCAGATCCTGGGGGACCAGTACGGGAACATCCTTCACCTC TACGAGCGGGACTGCTCCATCCAGCGGCGGCACCAGAAAGTGGTGGAGATCGCCCCGGCT GCCCACTTGGACCCCCAGCTGCGCACCCGGCTCACTAGCGACTCCGTCAAGCTTGCAAAG CAGGTGGGCTACGAGAACGCGGGCACCGTGGAGTTCCTGGTGGACAGGCACGGCAAGCAC TACTTCATCGAGGTCAACTCGCGCCTGCAGGTGGAGCACACGGTGACCGAGGAGATCACA GATGTGGACCTGGTCCACGCCCAGATCCACGTGGCCGAGGGCCGGAGCCTGCCTGACCTG GGCCTCCGGCAGGAGAACATCCGCATCAACGGCTGTGCCATCCAGTGCCGGGTTACCACC GAGGACCCTGCGCGCAGCTTCCAGCCCGACACCGGCCGCATCGAGGTGTTCCGGAGCGGG GAGGGCATGGGCATCCGCCTGGACAACGCCTCTGCCTTCCAAGGCGCCGTCATCTCCCCC CACTACGACTCCCTGCTGGTCAAGGTCATCGCTCACGGCAAGGACCACCCCACGGACGCC ACCAAGATGAGCAGAGCCCTGGCCGAGTTCCGAGTCCGAGGCGTGAAGACCAACATCCCC TTCCTGCAGAACGTGCTCAACAACCAGCAGTTCCTGGCAGGCACCGTGGACACGCAGTTC ATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCCGCACAGAACCGGGCCCAGAAGCTG CTGCACTACCTCGGACACGTCATGGTGAATGGCCCAACTACTCCGATCCCCGTCAAGGCC AGCCCCAGCCCCACGGACCCCATCGTCCCTGTGGTGCCCATAGGCCCACCCCCAACGGGT TTCAGAGACATCCTGCTACGGGAGGGGCCCGAGGGCTTTGCTCGAGCGGTGCGGAACCAT GAGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACT CGAGTGCGCACCCACGATCTCAAAAAGATCTCCCCCTATGTTGCCCACAGCTTCAACAAA CTCTTCAGCATAGAGAACTGGGGAGGAGCCACCTTTGACGTCGCCATGCGCTTCCTGTAC GAGTGCCCCTGGCGACGGCTGCAGGAGCTCCGGGAGCTCGTCCCCAACATCCCATTCCAG ATGCTGCTGCGGGGGGCCAACGCCGTGGGCTACACCAACTACCCCGACAATGTGGTCTTC AAGTTCTGCGAGGTGGCCAAGGAGAATGGCATGGACATCTTCCGGGTCTTTGACTCCCTC AACTACCTGCCCAACCTGCTGCTGGGCATGGAGGCGGCGGGCAGTGCTGGTGGCGTGGTG GAGGCCGCCATCTCCTACACGGGTGACGTGTCCGACCCCAGCCGCACCAAGTACTCGCTG CAGTACTACATGGGCTTGGCCGAGGAGCTGGTGCGAGCCGGCACCCACATCCTGTGCATC AAGGACATGGCTGGGCTGCTGAAGCCTACGGCCTGCACCATGCTGGTCAGCTCCCTCCGG GACCGCTTCCCTGACCTCCCGCTGCACATCCACACCCACGACACGTCAGGGGCGGGCGTG GCAGCCATGCTGGCCTGTGCTCACGCAGGGGCTGACGTGGTGGATGTGGCGGCTGACTCC ATGTCTGGAATGACATCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCCGAGGGACG CCCCTGGACACAGGCGTGCCCCTGGAGCGTGTGTTCGACTACAGCGAGTACTGGGAGGGG GCCCGGGGGCTGTACGCGGCCTTTGACTGCACGGCCACCATGAAGTCTGGCAACTCGGAC GTGTATGAGAACGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCGCACAGC ATGGGGCTCGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTACGTGGAGGCCAACCAGATG CTGGGCGACCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTC ATGGTGCAGAACGGGCTGACCCGAGCTGAGGCCGAAGCGCAGGCAGAGGAGCTGTCCTTC CCCCGCTCGGTGGTGGAGTTCCTGCAGGGCTACATCGGCATCCCCCACGGGGGCTTCCCA GAGCCCCTTCGCTCCAAGGTGCTGAAAGACCTGCCGAGGGTGGAGGGCCGGCCAGGAGCC TCCCTCCCACCCCTGGACCTGCAGGCGCTGGAGAAGGAGCTGACGGAACGGCACGGGGAG GAGGTGACCCCGGAGGACGTGCTCTCAGCCGCCATGTACCCCGACGTCTTTGCCCACTTC AAGGACTTCACTGCCACCTTCGGCCCCCTGGACAGCCTCAATACGCGCCTCTTCCTGCAG GGACCCAAGATTGCAGAGGAGTTTGAGGTGGAGCTGGAGCGAGGCAAGACGCTGCACATC AAAGCCTTGGCCATAAGTGACCTCAACCGGGCGGGCCAGAGGCAGGTCTTCTTCGAGCTC AACGGACAGCTGCGGTCCATCCTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTC CACCCCAAGGCCCTGAAGGACGTCAAGGGCCAGATTGGGGCACCCATGCCCGGGAAGGTG ATAGACATCAAGGTGGCAGCAGGGGCCAAGGTGACCAAGGGCCAACCCCTGTGTGTGCTC AGCGCCATGAAGATGGAGACTGTAGTGACCTCGCCCGTGGAGGGCACTGTCCGCAAGGTC CACGTGACTAAGGACATGACGCTGGAGGGTGACGACCTCATCCTGGAGATCGAGTGA 1178 129698.0 6.83 None >Pyruvate carboxylase, mitochondrial MLKFQTVRGSLRLLAIRRTSTATAASPNVRRLEYKPIKKVMVANRGEIAIRVFRACTELG IRTVAVYSEQDTGQMHRQKADEAYLIGRGLAPVQAYLHIPDIIKVAKENNVDAVHPGYGF LSERADFAQACQDAGVRFIGPSPEVVRKMGDKVEARAIAIAAGVPVVPGTDAPITSLHEA HEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEELEENYTRAYSEALAAFGNGALFVEKFIE KPRHIEVQILGDQYGNILHLYERDCSIQRRHQKVVEIAPAAHLDPQLRTRLTSDSVKLAK QVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEHTVTEEITDVDLVHAQIHVAEGRSLPDL GLRQENIRINGCAIQCRVTTEDPARSFQPDTGRIEVFRSGEGMGIRLDNASAFQGAVISP HYDSLLVKVIAHGKDHPTAATKMSRALAEFRVRGVKTNIPFLQNVLNNQQFLAGTVDTQF IDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPIVPVVPIGPPPTG FRDILLREGPEGFARAVRNHEGLLLMDTTFRDAHQSLLATRVRTHDLKKISPYVAHSFNK LFSIENWGGATFDVAMRFLYECPWRRLQELRELVPNIPFQMLLRGANAVGYTNYPDNVVF KFCEVAKENGMDIFRVFDSLNYLPNLLLGMEAAGSAGGVVEAAISYTGDVSDPSRTKYSL QYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGV AAMLACAHAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTGVPLERVFDYSEYWEG ARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQM LGDLIKVTPSSKIVGDLAQFMVQNGLTRAEAEAQAEELSFPRSVVEFLQGYIGIPHGGFP EPLRSKVLKDLPRVEGRPGASLPPLDLQALEKELTERHGEEVTPEDVLSAAMYPDVFAHF KDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAISDLNRAGQRQVFFEL NGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVAAGAKVTKGQPLCVL SAMKMETVVTSPVEGTVRKVHVTKDMTLEGDDLILEIE AAO27903.1 Q29RK2 PYC_BOVIN AY185595 PC