| Identification |
|---|
| BMDB Protein ID
| BMDBP00628 |
| Secondary Accession Numbers
| |
| Name
| Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| DLST |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). |
| Pathways
|
- Amino-acid degradation
- Glutaryl-CoA from L-lysine: step 6/6
- L-lysine degradation via saccharopine pathway
|
| Reactions
|
| Oxoadipic acid + Coenzyme A → Glutaryl-CoA + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| DLST |
| Gene Sequence
|
>1368 bp
ATGCTGTCCCGGTCCCGCTGCGCGTCCCGGGCGTTCAGCCGCTCGCTGTCCGCCTTCCAG
AAGGGGAACTGCCCTCTAGTGAGACGTTCCCTGCCTGGGATCTCCTTATGTCAGGGACCA
GGTTACCCTGACAGCAGGAAGACTGTCATTAACAGCAGTAATATCTTCAGCGTTCGCTTC
TTTAGAACTACAGCTGTGTGCAAGGATGATGTGATTACAGTCAAAACCCCAGCATTTGCA
GAATCTGTCACAGAGGGGGATGTCAGGTGGGAGAAAGCTGTTGGAGACACAGTTGCAGAA
GATGAAGTGGTTTGTGAGATTGAAACTGACAAGACCTCTGTGCAGGTTCCGTCACCAGCA
AATGGCGTGATTGAAGCTCTTTTGGTACCTGATGGGGGAAAAGTAGAAGGAGGCACTCCT
CTTTTCACACTCAGGAAAACTGGCGCTGCTCCTGCTAAGGCCAAGCCAGCTGCAGCCCCT
GCTGCCGCAGCCCCAAAAGCAGAACCCACAGTGTCTGCTGTTCCTCCTCCCCCTGCAGCA
CCTATACCCACCCAGATGCCACCTGTGCCCTCGCCCTCACAGCCGCTCACTAGCAAACCA
GTGTCTGCTGTAAAACCCACCGCTGCCCCTCCAAGAGCTGAGGCAGGAGCTGGTGTAGGT
CTGCGTTCAGAACATCGGGAGAAGATGAACAGGATGCGGCAACGCATCGCCCAGCGTCTG
AAGGAGGCTCAGAACACCTGCGCGATGCTCACCACTTTCAATGAGATTGACATGAGTAAT
ATCCAGGAGATGCGGGCTCGGCACAAAGATGCTTTTCTGAAGAAACATAACCTCAAACTA
GGCTTCATGTCAGCATTTGTGAAGGCCTCAGCCTTTGCCTTGCAGGAGCAGCCTGTGGTA
AATGCAGTGATTGACGATGCAACCAAAGAGGTGGTGTATAGGGATTATATTGACATCAGC
GTTGCGGTGGCCACCCCTCGGGGTCTGGTTGTTCCCGTCATCAGGAATGTGGAAACAATG
AATTATGCCGATATTGAGCGAACCATCAGTGAACTGGGAGAGAAGGCCCGGAAGAATGAA
CTTGCCATTGAAGATATGGATGGTGGTACTTTTACCATCAGCAATGGAGGTGTTTTTGGC
TCGCTCTTTGGAACACCCATCATCAACCCCCCTCAGTCTGCCATCCTGGGCATGCATGCC
ATCGTTGATAGGCCAGTGGTCATAGGAGGCAAGGTGGAGGTGCGGCCCATGATGTACGTG
GCCCTGACGTATGATCACCGGCTGATCGATGGCAGAGAGGCTGTGACTTTCCTCCGCAAA
ATTAAGGCAGCGGTAGAGGATCCCAGAGTCCTCCTACTGGACCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 455 |
| Molecular Weight
| 48973.0 |
| Theoretical pI
| 9.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
MLSRSRCASRAFSRSLSAFQKGNCPLVRRSLPGISLCQGPGYPDSRKTVINSSNIFSVRF
FRTTAVCKDDVITVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPA
NGVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAAAPAAAAPKAEPTVSAVPPPPAA
PIPTQMPPVPSPSQPLTSKPVSAVKPTAAPPRAEAGAGVGLRSEHREKMNRMRQRIAQRL
KEAQNTCAMLTTFNEIDMSNIQEMRARHKDAFLKKHNLKLGFMSAFVKASAFALQEQPVV
NAVIDDATKEVVYRDYIDISVAVATPRGLVVPVIRNVETMNYADIERTISELGEKARKNE
LAIEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHAIVDRPVVIGGKVEVRPMMYV
ALTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
|
| External Links |
|---|
| GenBank ID Protein
| ABG67046.1 |
| UniProtKB/Swiss-Prot ID
| P11179 |
| UniProtKB/Swiss-Prot Entry Name
| ODO2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT026207 |
| GeneCard ID
| DLST |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
