| Identification |
|---|
| BMDB Protein ID
| BMDBP00635 |
| Secondary Accession Numbers
| None |
| Name
| Nicotinate phosphoribosyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| NAPRT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. |
| Pathways
|
- Cofactor biosynthesis
- NAD(+) biosynthesis
- Nicotinate D-ribonucleotide from nicotinate: step 1/1
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| NAPRT |
| Gene Sequence
|
>1602 bp
ATGGCGGCGGAGCAGGACCCCGAGGGGCGCGCGGCGGCGCGGCCGCTGCTCACCGACCTG
TACCAAGCCACCATGGCGCTGGGCTATTGGCGCGCCGGCCGCGCGCAGGACCAGGCCGAG
TTCGAGCTCTTCTTCCGCCAGTGCCCGTTCGGCGGAGCCTTCGCCTTGGCCGCGGGACTG
CGCGACTGCGTGCGTTTCCTGCGTGCCTTCCGCCTGCGGGACGCAGATGTGCAGTTCCTG
GCTTCGGCGCTGCCCCCAGACACAGACCCCGCGTTCTTTGAGCACCTTCGTGCACTCGAC
TGCTCTGGTGTGACGGTGCGGGCCCTGCCCGAGGGCTCCCTCGCCTTCCCCGGCGTTCCG
CTACTGCAGGTGTCCGGGCCGCTCCTGGTGGTGCAGCTGCTGGAGACGCCGCTCCTCTGC
CTGGTCAGCTACGCCAGCCTCATCGCCACAAATGCCGCGCGCCTTCGCCTGATCGCAGGG
CCCGACAAGCGGCTGCTGGAAATGGGTCTTCGGCGTGCTCAGGGCCCCGACGGGGGTCTT
ACTGCTTCTACCTACAGCTACCTGGGCGGCTTCGATGCCAGCAGCAACGTGCTCGCAGGA
CAGCTAAGGGGCGTGCCGGTGGCTGGGACCCTGGCGCACTCCTTTGTCACTTCCTTTTCA
GGCAGTGAGGTGCCCCCTGACCCGATGTTGGCTCCAGCGGCTGGTCAGGGCTCCCAGGTG
GATCTGGCTGCCAGTGTGGAGATGTGGCTGGAGCGTGTGTGTGGCCACCTGGGGCTGGGT
GTGCAAGAGCCGCATCGGGGAGAGCGGGCAGCCTTTGTGGCCTATGCCCTGGCCTTTCCC
CGGGCCTTCCAGGGCCTGCTGGACACCTACAGTGTGCGGAGGAGCGGGCTCCCCAACTTC
CTGGCTGTAGCCCTGGCCCTGCAGGAGCTGGGCTACCAGGCAGTGGGCGTGAGGCTGGAC
AGTGGCGATCTGCTTCAGCAGGCTCGGGAGATCCGCGGGGTCTTCCGGACAGCGGCAGCC
CAGTTCGGGGTGCCCTGGCTGCAGTCGGTACCCATCGCTGTCAGCAACAACATTGACGAG
GAGGAGCTGGCCCGACTAGCCCAGAAGGGCAGTGAGGTGAACGTCATTGGCATCGGCACT
AGCGTGGTCACCTGCCCTCGCCAGCCTTCCCTGGGCTGTGTCTACAAGCTGGTGTCTGTG
GGAGGCCAGCCGCGGATGAAGCTGACCGAGGACCCCGAGAAGCAGACATTGCCTGGGAGC
AAGGCTGCCTTCCGGCTCCTGGGCTCTGATGATGTGCTGCAGTTGGCAGAGGAGCCACCT
CCCCAGGCTGGCCAGGAGCTGAGAGTGTGGCCTCGAGGGGCCCGGGAGTCCCGTACTGTG
AGGCCGGCCCACGTGGAGCCGCTGCTGCGACTCTGGGTCCAACAGGGACAGCTGTGTGAG
CCGCTGCCATCTCTGGCTGAATCCAGAGCCTTTGCCCAGCAGTCCCTGCACCGTCTGAGC
CCCGCCCACAGGCGGCTGGAGCAGCCGGCACTGTACCAGGTCGCACTGTCTGAGAAGCTC
CAGGCCCTGGTGGACAGACTGAGTGCCAGAGGAGCCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 538 |
| Molecular Weight
| 57871.0 |
| Theoretical pI
| 7.13 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinate phosphoribosyltransferase
MAAEQDPEGRAAARPLLTDLYQATMALGYWRAGRAQDQAEFELFFRQCPFGGAFALAAGL
RDCVRFLRAFRLRDADVQFLASALPPDTDPAFFEHLRALDCSGVTVRALPEGSLAFPGVP
LLQVSGPLLVVQLLETPLLCLVSYASLIATNAARLRLIAGPDKRLLEMGLRRAQGPDGGL
TASTYSYLGGFDASSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGQGSQV
DLAASVEMWLERVCGHLGLGVQEPHRGERAAFVAYALAFPRAFQGLLDTYSVRRSGLPNF
LAVALALQELGYQAVGVRLDSGDLLQQAREIRGVFRTAAAQFGVPWLQSVPIAVSNNIDE
EELARLAQKGSEVNVIGIGTSVVTCPRQPSLGCVYKLVSVGGQPRMKLTEDPEKQTLPGS
KAAFRLLGSDGSLLLDVLQLAEEPPPQAGQELRVWPRGARESRTVRPAHVEPLLRLWVQQ
GQLCEPLPSLAESRAFAQQSLHRLSPAHRRLEQPALYQVALSEKLQALVDRLSARGAL
|
| External Links |
|---|
| GenBank ID Protein
| AAI42358.1 |
| UniProtKB/Swiss-Prot ID
| A5PK51 |
| UniProtKB/Swiss-Prot Entry Name
| PNCB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC142357 |
| GeneCard ID
| NAPRT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
