| Identification |
|---|
| BMDB Protein ID
| BMDBP00639 |
| Secondary Accession Numbers
| None |
| Name
| 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| Synonyms
|
Not Available
|
| Gene Name
| ACMSD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in aminocarboxymuconate-semialdehyde decarboxy |
| Specific Function
| Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway (By similarity). |
| Pathways
|
- Quinolate metabolism
- Secondary metabolite metabolism
- Tryptophan Metabolism
|
| Reactions
|
| 2-Amino-3-carboxymuconic acid semialdehyde → 2-Aminomuconic acid semialdehyde + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| ACMSD |
| Gene Sequence
|
>1011 bp
ATGAAGATTGACATCCACACTCATATTTTACCAAGAGAATGGCCAGACCTAAAAAAGAGA
TTCGGTTATGGAGGCTGGGTGCAGCTCCAACACAATGGCAAGGGAGAAGCAAAGATGCTG
AAAGATGGGAAGGTCTTCAGAGTGGTCCAAGAGAACTGCTGGGATCCAGAAGCTCGTCTT
AGAGAAATGGACCAAACAGGAGTGACTGTGCAAGCCCTTTCCACGGTTCCTGTCATGTTT
AGCTACTGGGCCAAACCTCAGGACACTTTAGACCTGTGCCAGCTTCTGAACAACGACCTA
GCCGCCACCATTGCGAGCCACCCCAGGAGGTTTGTGGGTCTGGGGACGTTGCCCATGCAG
GCCCCTGAGCTGGCGGTTAAGGAGATGGAGCGCTGTGTGAGGAAGTTGGGCTTTCCCGGG
GTTCAGATCGGCTCCCACATCAACGAGTGGGACCTGAACGCACGGGAACTCTTCCCAGTG
TACGCGGAGGCTGAAAGGCTGAACTGTTCCCTATTTGTGCACCCCTGGGACATGCAGATG
GATGGACGGATGGCCAAATACTGGTTCCCTTGGCTCATAGGAATGCCAGCTGAGACCACT
GCAGCCATCTGTTCCATGATCATGGGTGGAGTGTTTGAGAAGTTTCCTAAACTGAAAGTG
TGCTTTGCACATGGAGGTGGTTCCTTCCCCTTCACAGTTGGAAGAATCTCCCATGGATTC
AGCATGCGTCCTGATCTGTGTGCACAGGACAATCCAACCAACCCAAAGAAATACCTTGGT
TCCTTTTATACAGACTCCTTGGTTCATGATCCTCTGGCCCTCAAACTGTTAACAGATGTC
ATAGGAAAGGATAAAGTCATTTTGGGAACTGATTACCCCTTCCCACTAGGTGAGTTGGAA
CCTGGGAAACTGATAGAATCAATGGGAGAATTTGATGCAGAAACCAAGGATAAACTCAAA
GCTGGCAATGCCCTAGAATTTTTGGGGCTTGAAAGGAAACAATTTGAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 37923.0 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
MKIDIHTHILPREWPDLKKRFGYGGWVQLQHNGKGEAKMLKDGKVFRVVQENCWDPEARL
REMDQTGVTVQALSTVPVMFSYWAKPQDTLDLCQLLNNDLAATIASHPRRFVGLGTLPMQ
APELAVKEMERCVRKLGFPGVQIGSHINEWDLNARELFPVYAEAERLNCSLFVHPWDMQM
DGRMAKYWFPWLIGMPAETTAAICSMIMGGVFEKFPKLKVCFAHGGGSFPFTVGRISHGF
SMRPDLCAQDNPTNPKKYLGSFYTDSLVHDPLALKLLTDVIGKDKVILGTDYPFPLGELE
PGKLIESMGEFDAETKDKLKAGNALEFLGLERKQFE
|
| External Links |
|---|
| GenBank ID Protein
| AAI22782.1 |
| UniProtKB/Swiss-Prot ID
| Q0II68 |
| UniProtKB/Swiss-Prot Entry Name
| ACMSD_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122781 |
| GeneCard ID
| ACMSD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
