| Identification |
|---|
| BMDB Protein ID
| BMDBP00642 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Synonyms
|
Not Available
|
| Gene Name
| PPP2CA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| PPP2CA |
| Gene Sequence
|
>930 bp
ATGGACGAGAAGGTGTTCACCAAGGAGCTGGACCAGTGGATCGAGCAGCTGAACGAGTGC
AAGCAGCTGTCTGAGTCCCAGGTTAAGAGCCTCTGCGAGAAGGCTAAAGAAATCCTGACA
AAAGAATCCAATGTGCAAGAAGTTCGATGTCCAGTCACTGTCTGTGGAGATGTGCATGGG
CAATTTCATGATCTCATGGAACTGTTTAGAATTGGTGGCAAATCACCAGATACAAATTAC
TTGTTTATGGGCGATTATGTTGACAGAGGATATTATTCAGTGGAAACAGTTACTCTGCTT
GTAGCTCTTAAGGTTCGTTACCGTGAACGTATCACCATTCTTCGAGGAAATCATGAGAGC
AGACAGATCACACAAGTATATGGTTTCTACGATGAGTGTTTAAGGAAATACGGAAATGCA
AATGTTTGGAAGTATTTTACAGACCTTTTTGACTATCTTCCTCTCACTGCCTTGGTGGAT
GGGCAGATCTTCTGTCTACATGGTGGCCTCTCACCATCCATAGATACACTGGATCACATC
AGAGCACTTGATCGCCTACAAGAAGTTCCTCATGAGGGTCCAATGTGTGACTTGCTGTGG
TCAGATCCAGATGACCGTGGAGGTTGGGGTATATCTCCTCGAGGAGCTGGTTACACCTTT
GGGCAGGATATTTCTGAGACATTTAATCATGCCAATGGCCTCACGTTGGTGTCTAGAGCT
CATCAGCTGGTGATGGAGGGATATAACTGGTGCCATGACCGAAATGTAGTAACGATTTTC
AGTGCTCCAAACTATTGTTATCGTTGTGGTAACCAAGCTGCAATCATGGAACTTGATGAT
ACTCTAAAATACTCTTTCTTGCAGTTTGACCCAGCACCTCGCAGAGGCGAGCCACATGTT
ACTCGTCGTACCCCAGACTACTTCCTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35594.0 |
| Theoretical pI
| 5.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
|
| External Links |
|---|
| GenBank ID Protein
| CAA36789.1 |
| UniProtKB/Swiss-Prot ID
| P67774 |
| UniProtKB/Swiss-Prot Entry Name
| PP2AA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X52554 |
| GeneCard ID
| PPP2CA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
