| Identification |
|---|
| BMDB Protein ID
| BMDBP00655 |
| Secondary Accession Numbers
| |
| Name
| Dopamine beta-hydroxylase |
| Synonyms
|
Not Available
|
| Gene Name
| DBH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in copper ion binding |
| Specific Function
| Conversion of dopamine to noradrenaline. |
| Pathways
|
- (R)-noradrenaline biosynthesis
- (R)-noradrenaline from dopamine: step 1/1
- Catecholamine biosynthesis
|
| Reactions
|
| Dopamine + Ascorbic acid + Oxygen → Norepinephrine + Dehydroascorbic acid + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| DBH |
| Gene Sequence
|
>1833 bp
ATGCAGGTCCCCAGCCCCAGCGTGCGCGAGGCGGCCTCCATGTACGGCACCGCGGTGGCC
GTCTTCCTGGTCATCCTCGTGGCTGCACTGCAGGGCTCGGCCCCCGCCGAGAGCCCCTTC
CCCTTCCACATCCCCCTGGACCCCGAGGGGACCCTGGAGCTGTCCTGGAACATCAGCTAT
GCGCAGGAGACCATCTACTTCCAGCTCCTGGTGCGGGAGCTCAAGGCTGGTGTCCTGTTT
GGGATGTCGGACCGAGGGGAGCTGGAGAATGCTGACTTGGTGGTGCTCTGGACTGACAGG
GACGGCGCCTACTTTGGGGATGCCTGGAGTGACCAGAAGGGGCAGGTCCACCTGGACTCC
CAGCAGGATTACCAGCTTCTGCGGGCACAGAGGACTCCAGAAGGCCTGTACCTGCTCTTC
AAGAGGCCTTTTGGCACCTGTGACCCCAACGACTACCTCATCGAGGACGGCACCGTCCAC
CTGGTGTATGGATTCCTGGAGGAGCCGCTCCGGTCGCTGGAGTCCATCAACACATCCGGC
TTGCACACGGGGCTGCAGAGGGTGCAGCTGCTGAAGCCCAGCATCCCGAAGCCGGCCCTG
CCCGCGGACACGTGCACCATGGAGATCCGCGCCCCCGACGTCCTCATCCCCGGCCAGCAG
ACCACGTACTGGTGCTACGTGACCGAGCTCCCGGACGGCTTCCCCCGGCACCACATCGTC
ATGTACGAGCCCATCGTCACCGAGGGCAACGAGGCGCTGGTGCACCACATGGAGGTCTTT
CAGTGCGCCGCCGAGTTTCGAGACCATCCCCACTTCAGCGGGCCCTGCGACTCCAAGATG
AAGCCGCAGCGGCTCAACTTCTGCCGTCACGTGCTGGCCGCCTGGGCCCTGGGCGCCAAG
GCCTTTTACTACCCAGAGGAAGCAGGCCTGGCCTTCGGGGGGCCCGGCTCCTCCAGATTT
CTCCGCCTGGAAGTTCACTACCACAACCCACTGGTGATAACAGGCCGGCGCGACTCCTCG
GGCATCCGCCTGTACTACACGGCTGCGCTGCGGCGCTTCGACGCGGGCATCATGGAGCTG
GGCCTGGCGTACACGCCCGTGATGGCCATCCCCCCGCAGGAGACGGCCTTCGTCCTCACC
GGCTACTGCACGGACAAGTGCACCCAGCTGGCCCTGCCCGCCTCAGGGATTCACATCTTC
GCCTCTCAGCTCCACACGCACCTGACCGGCCGGAAGGTGGTCACAGTGCTGGCCAGGGAC
GGCCGGGAGACAGAGATCGTGAACAGGGACAACCACTACAGCCCACACTTCCAGGAGATC
CGCATGTTGAAGAAGGTCGTGTCTGTCCAGCCGGGAGACGTGCTCATCACCTCTTGCACA
TACAACACGGAAGACAGGAGGCTGGCCACCGTGGGGGGCTTCGGGATCCTGGAGGAGATG
TGCGTCAACTATGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAGAGCGCCGTG
GACCCTGGCTTCCTGCACAAGTACTTCCGCCTCGTGAACAGGTTCAACAGCGAGGAAGTC
TGCACCTGCCCCCAGGCGTCTGTCCCTGAGCAGTTTGCCTCCGTGCCCTGGAACTCCTTC
AACCGCGAGGTGCTCAAGGCCCTGTACGGCTTCGCACCCATCTCCATGCACTGCAACAGG
TCCTCGGCCGTCCGCTTCCAGGGCGAGTGGAATCGGCAGCCCCTGCCTGAGATCGTGTCC
AGGTTGGAAGAGCCCACCCCTCAGTGCCCAGCCAGCCAGGCTCAGAGCCCCGCCGGCCCC
ACCGTGCTGAACATCAGTGGGGGCAAAGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 610 |
| Molecular Weight
| 68141.0 |
| Theoretical pI
| 6.23 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dopamine beta-hydroxylase
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
|
| External Links |
|---|
| GenBank ID Protein
| AAA30356.1 |
| UniProtKB/Swiss-Prot ID
| P15101 |
| UniProtKB/Swiss-Prot Entry Name
| DOPO_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J02890 |
| GeneCard ID
| DBH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
