| Identification |
|---|
| BMDB Protein ID
| BMDBP00664 |
| Secondary Accession Numbers
| None |
| Name
| 5,6-dihydroxyindole-2-carboxylic acid oxidase |
| Synonyms
|
Not Available
|
| Gene Name
| TYRP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in copper ion binding |
| Specific Function
| Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. |
| Pathways
|
- Degradation of Superoxides
- Melanin biosynthesis
- Pigment biosynthesis
|
| Reactions
|
| 2 Hydrogen peroxide → Oxygen +2 Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| TYRP1 |
| Gene Sequence
|
>1614 bp
ATGAAATCTCCTACACTCCTCTCTCTGGGTTACATGTTCCTAGTCCTGCTTTTTTTCCAG
CAGGCCTGGGCTCAGTTCCCAAGAGAGTGTGCTACCATTGAGGCTTTGAGGAATGGCGTG
TGTTGCCCAGACCTGTCCCCACTGTCTGGGCCTGGGTCTGACCGCTGCGGTCTCTCATCA
GGGAGGGGCAGATGTGAGGTGGTGATAGCCGACTCCCGGCCCCACAGCCACCACTACCCG
CACGATGGCAGAGATGACCGAGAGGGCTGGCCCACACGCTCCTTCAACAGGACATGCCAC
TGCAATGGCAATTTCTCAGGACACAACTGTGGAACCTGCCGCCCTGGCTGGGGAGGGGCT
GCCTGTGACCAGAGGGTTCTCACAGTCAGGAGAAACCTTCTGGACTTAAGCACAGAAGAA
AAGAACCGCTTTGTCCGGGCCCTGGATATGGCAAAGCGCACCACTCACCCTCAGTTTGTC
ATTGCCACAAGGAGGTCAGAAGAAATACTGGGGCCAGATGGCAACACACCGCAGTTTGAG
AACATTTCCATTTATAACTACTTCGTTTGGACACACTACTACTCAGTCAAAAAGACTTTC
TTGGGAGCAGGACAGGAAAGCTTTGGTGAGGTGGATTTCTCTCACGAGGGACCAGCATTT
CTCACCTGGCACAGGTACCACCTGCTGCAGCTGGAGAGAGACATGCAGGAAATGTTGCAG
GATCCTTCTTTCTCCCTCCCTTACTGGAATTTTGCCACTGGGAAGAACACCTGCGACATT
TGCACCGATGACTTGATGGGATCAAGAAGCAACTTTGATTCCACTCTTATAAGCCCGAAC
TCTGTCTTTTCTCAATGGCGAGTGGTCTGCGAATCCTTGGAAGATTATGATACCCTGGGA
ACCCTTTGCAACAGCACTGAGGGTGGGCCAATTAAGAGAAACCCAGCTGGAAATGTGGCC
AGGCCAATGGTGCAACGTCTTCCTAAACCACAGGATGTCGCGCAGTGCTTGGAAGTTGGT
TCATATGACACACCTCCTTTTTATTCTAATTCTACAAACAGCTTCCGAAACACAGTGGAA
GGTTACAGTCATCCCACAGGAAGGTATGACCCTGCTGTGCGAAGCCTTCACAATTTGGCT
CATCTATTCCTGAATGGAACAGGGGGACAAACTCATTTATCTCCCAATGATCCTATTTTT
GTCCTCCTACATACATTCACTGATGCAGTATTTGATGAATGGCTGAGGCGATACAATGCT
GATATATCCACATATCCACTGGAAAATGCCCCTATTGGACATAACAGACAATACAATATG
GTACCATTTTGGCCTCCAGTTACCAACATAGAAATGTTTGTTACTGCTCCAGACAACCTG
GGCTATACTTACGAAGTTCAATGGCCAAGTCGGAGTTTTAGCATTTCTGAGATTGTCACC
ATAGCAGTAGTGGCTGCATTATCACTGGTTGCGGTCATTTTTGCGGGCGCTTCTTGTCTG
ATTCGTGCCAGAAGCAACATGGATGAAGCAAATCAGCCTCTCCTTACTGATCAGTATCAA
CACTACATTGAAGAATATGAAAAAATCCATAATCCTAACCAGTCTGTGGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 537 |
| Molecular Weight
| 60617.0 |
| Theoretical pI
| 6.19 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>5,6-dihydroxyindole-2-carboxylic acid oxidase
MKSPTLLSLGYMFLVLLFFQQAWAQFPRECATIEALRNGVCCPDLSPLSGPGSDRCGLSS
GRGRCEVVIADSRPHSHHYPHDGRDDREGWPTRSFNRTCHCNGNFSGHNCGTCRPGWGGA
ACDQRVLTVRRNLLDLSTEEKNRFVRALDMAKRTTHPQFVIATRRSEEILGPDGNTPQFE
NISIYNYFVWTHYYSVKKTFLGAGQESFGEVDFSHEGPAFLTWHRYHLLQLERDMQEMLQ
DPSFSLPYWNFATGKNTCDICTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEDYDTLG
TLCNSTEGGPIKRNPAGNVARPMVQRLPKPQDVAQCLEVGSYDTPPFYSNSTNSFRNTVE
GYSHPTGRYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNA
DISTYPLENAPIGHNRQYNMVPFWPPVTNIEMFVTAPDNLGYTYEVQWPSRSFSISEIVT
IAVVAALSLVAVIFAGASCLIRARSNMDEANQPLLTDQYQHYIEEYEKIHNPNQSVV
|
| External Links |
|---|
| GenBank ID Protein
| AAL38167.2 |
| UniProtKB/Swiss-Prot ID
| Q8WN57 |
| UniProtKB/Swiss-Prot Entry Name
| TYRP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF445638 |
| GeneCard ID
| TYRP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
