1.0 2018-05-07 22:23:30 UTC 2020-05-20 21:08:51 UTC BMDBP00680 Enzyme ALKBH3 Replication, recombination and repair Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron. BMDB0000692 Iron 15 >861 bp ATGGAGGACAAAAGACGGCGAGCCCGAGTGCAGGGAGCCTGGGCTGGTCCTGCTAAGAGC CAGGCCACTGCTCAGCCAGCTCCCACTGCTGAGAACAATCTCCAACAGAGACCTGGTAAA GCCTGGATGAACAAGGAGCAGCATCTGTCTGACAGACAGTTTGTGTTCAAAGAACCCCAG GAGGGGGTACGCAGAGCCCCAGAGCCACGAGTGATTGAAAAAGAGGGTGTGTATGAAATC AGCATGTCACCCACAGGCATATCTAGGGTGTGTTTGTGTCCTGGCTTTGTTGACTTGAAA GAGGCCGACTCAGTGTTTGAACAGCTTTGTCGGGATGTTCCCTGGAAGCAGAGGACTGGC ATCAGAGACGATGTAACTTACCAGCAACCAAGACTTACAGCATGGTATGGAGAACTTCCT TACACTTATTCAAGAATCACTATGGAACCAAATCCTCACTGGCATCCTGTGCTGCTCATG CTGAAGAACCAAATTGAAGAGAACACTGGCCACAGCTTCAACTCCTTGCTTTGCAATCTT TACCGAAATGAGAAGGACAGCGTGGACTGGCACAGCGATGATGAACCTTCACTGGGGAGG TGCCCCATCATTGCTTCACTCAGTTTTGGTGCCACACGCATGTTTGAGATGAGAAAGAAG CCCCCACCAGAAGACAATGGAGACTACACGTATGTGGAGAGAGTGAAGATACCCTTGGAT CATGGGACCCTGTTAATCATGGAAGGGGCCACGCAGGCAGACTGGCAGCATCGAGTGCCC AAAGAGTACCACTCCAGAGAACCAAGAATAAACTTGACCTTTCGGACAGTTTATCCTGAC CCTCGAGGGGCGCACTGGTGA 286 33156.0 7.59 None >Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 MEDKRRRARVQGAWAGPAKSQATAQPAPTAENNLQQRPGKAWMNKEQHLSDRQFVFKEPQ EGVRRAPEPRVIEKEGVYEISMSPTGISRVCLCPGFVDLKEADSVFEQLCRDVPWKQRTG IRDDVTYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLLMLKNQIEENTGHSFNSLLCNL YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRMFEMRKKPPPEDNGDYTYVERVKIPLD HGTLLIMEGATQADWQHRVPKEYHSREPRINLTFRTVYPDPRGAHW AAI09833.1 Q32L00 ALKB3_BOVIN BC109832 ALKBH3