| Identification |
|---|
| BMDB Protein ID
| BMDBP00681 |
| Secondary Accession Numbers
| None |
| Name
| Cytoplasmic aconitate hydratase |
| Synonyms
|
Not Available
|
| Gene Name
| ACO1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. |
| Pathways
|
|
| Reactions
|
| Citric acid → Isocitric acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ACO1 |
| Gene Sequence
|
>2670 bp
ATGAGCAACCCATTTGCACACCTTGTTGAGCCTTTGGATCCTGCACAACCAGGAAAGAAG
TTCTTCAATTTGAATAAATTGGAGGATTCCAGATATGGATCCTTACCATTTTCTATCAGA
GTTCTCCTGGAGGCAGCCATTCGGAACTGTGATCAATTTTTGGTGAAGAAAAATGATGTT
GAAAATATCCTGAATTGGAAGGTCATGCAGCATAAGAACATAGAAGTGCCCTTTAAGCCT
GCCCGAGTCATCCTGCAGGACTTTACGGGTGTGCCAGCTGTGGTTGACTTTGCTGCCATG
CGTGATGCTGTGAAAAAGTTAGGAGGCAATCCAGAGAAAATAAACCCCATCTGTCCTGCT
GATCTTGTCATTGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTAAAG
AAGAATCAAGACTTGGAATTTGAAAGAAATAAAGAACGATTTGAATTTTTAAAGTGGGGC
TCTCAGGCCTTTCACAACATGAGGATTATTCCACCGGGCTCAGGAATCATCCACCAGGTG
AATCTGGAGTATTTGGCAAGAGTGGTCTTTGATCAGGATGGATATTACTACCCAGACAGC
CTTGTGGGCACAGATTCGCACACCACCATGATTGATGGTTTGGGTGTCCTTGGTTGGGGT
GTGGGTGGTATCGAAGCAGAAGCTGTGATGCTGGGCCAGCCAATCAGCATGGTGCTTCCC
CAGGTGATCGGCTACAGGCTGGTGGGAAATCCCCACCCCCTGGTCACATCCACTGACATC
GTGCTCACCATCACCAAGCACCTCCGCCAGGTTGGGGTAGTAGGCAAGTTTGTCGAGTTC
TTTGGGCCAGGAGTAGCCCAACTGTCCATTGCCGACCGAGCTACAATTGCCAACATGTGT
CCAGAGTATGGGGCCACTGCCGCCTTTTTCCCAGTTGATGAAGTTAGTATCAAGTACCTG
GTGCAGACAGGTCGTGACAAAGAAAAAGTAAAGCATATTAAACAGTATCTTCAGGCTGTA
GGAATGTTTCGGGACTTCAGTGACTCCTCTCAAGACCCAGACTTTGCCCAGGTTGTGGAA
TTAGACTTGAAAACAGTAGTGCCTTGCTGCAGCGGACCCAAAAGGCCTCAGGACAAAGTT
GCCGTGTCTGATATGAAAAAGGACTTTGAGAGCTGCCTGGGGGCCAAGCAAGGATTTAAA
GGATTCCAGGTTGCTCCAGACCATCATAATGACCATAAGACATTTATCTATAATAACAGC
AAGTTCACCCTTGCTCATGGTTCTGTGGTAATCGCTGCCATTACTAGCTGCACAAACACC
AGTAATCCATCTGTGATGTTAGGGGCAGGCTTGTTAGCGAAGAAGGCTGTGGATGCAGGC
CTGAGCGTGAAGCCTTACATCAAAACTAGCCTGTCTCCTGGCAGTGGTGTGGTCACCTAC
TACCTGCGGGAAAGCGGAGTCATGCCTTACCTGTCTCAGCTTGGGTTTGACGTGGTGGGC
TATGGCTGCATGACCTGCATCGGCAACAGCGGGCCCTTACCGGAAGCTGTGGTAGAAGCC
ATCGTACAGGGGGACCTCGTAGCTGTTGGAGTACTGTCTGGGAACAGGAACTTTGAAGGG
CGAGTCCACCCCAATACCCGGGCCAACTATTTAGCCTCTCCGCCCTTAGTAATAGCCTAT
GCGATTGCTGGGACCATCAGGATCGACTTTGAGAAAGAGCCACTAGGTGTCAATGCCAAG
GGACAGCAAGTATTTCTGAAAGATATCTGGCCGACCAGAGATGAGATCCAGGCAGTGGAA
CGTCAGTACGTGATCCCTGGGATGTTTAAGGAGGTCTACCAGAAAATAGAGACTGTGAAT
GAGAGCTGGAATGCCTTAGCAGCCCCGTCAGATAAGCTATATTGCTGGAATCCCAAATCT
ACATACATTAAATCACCACCATTCTTTGAAGACCTGACTTTGGATCTTCAGCCCCCTAAG
TCTATTGTGGATGCCTATGTGCTATTAAACTTGGGAGATTCAGTAACAACAGACCACATC
TCTCCAGCTGGAAACATCGCAAGAAACAGCCCTGCTGCTCGCTACTTAACTAACAGAGGC
CTGACTCCTCGAGAATTCAACTCCTACGGCTCCCGCCGAGGGAATGATGCCATCATGGCA
CGGGGGACATTTGCCAACATCCGCTTATTAAACAAATTCTTGAACAAGCAGGCACCGCAG
ACTATCCACCTGCCTTCTGGTGAAATTCTTGACGTGTTCGACGCCGCTGAGCGGTACCAG
CAGGCGGGCCTCCCCCTCATCGTCCTGGCGGGCAAAGAGTACGGCTCGGGCAGCTCCCGA
GACTGGGCCGCCAAGGGCCCTTTCCTCCTGGGAATCAGAGCTGTCCTAGCAGAGAGTTAC
GAGCGCATTCACCGAAGTAACTTGGTCGGGATGGGGGTGATCCCTCTCGAGTACCTCCCT
GGGGAGAATGCAGACACCCTGGGACTCACTGGGCGTGAACGATACACTATTAGCATTCCA
GAAACCCTGAAACCACGAATGAAAGTCCAGATCAAGCTGGATACCGGGAAGACCTTCCAG
GCTGTCATGAGGTTTGACACCGACGTGGAGCTCACTTATTTCCATAACGGGGGCATCCTC
AACTACATGATCCGCAAGATGACCAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 889 |
| Molecular Weight
| 98204.0 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytoplasmic aconitate hydratase
MSNPFAHLVEPLDPAQPGKKFFNLNKLEDSRYGSLPFSIRVLLEAAIRNCDQFLVKKNDV
ENILNWKVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPICPA
DLVIDHSIQVDFNRRADSLKKNQDLEFERNKERFEFLKWGSQAFHNMRIIPPGSGIIHQV
NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLP
QVIGYRLVGNPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC
PEYGATAAFFPVDEVSIKYLVQTGRDKEKVKHIKQYLQAVGMFRDFSDSSQDPDFAQVVE
LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNNS
KFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLSVKPYIKTSLSPGSGVVTY
YLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEAVVEAIVQGDLVAVGVLSGNRNFEG
RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE
RQYVIPGMFKEVYQKIETVNESWNALAAPSDKLYCWNPKSTYIKSPPFFEDLTLDLQPPK
SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMA
RGTFANIRLLNKFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGSGSSR
DWAAKGPFLLGIRAVLAESYERIHRSNLVGMGVIPLEYLPGENADTLGLTGRERYTISIP
ETLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMTK
|
| External Links |
|---|
| GenBank ID Protein
| AAI20007.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCU1 |
| UniProtKB/Swiss-Prot Entry Name
| ACOC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120006 |
| GeneCard ID
| ACO1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
