| Identification |
|---|
| BMDB Protein ID
| BMDBP00682 |
| Secondary Accession Numbers
| None |
| Name
| Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PLOD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron ion binding |
| Specific Function
| Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| PLOD1 |
| Gene Sequence
|
>2181 bp
ATGCGGCTCCTGCTGCTCCTGGCCCCGTTGGGCTGGCTGCTTCTAGCCGAAACGAAGGGT
GACGCCAAGCCGGAGGACAACCTTTTGGTCCTCACTGTGGCTACGAAGGAGACCGAGGGG
TTCCGACGCTTTAAGCGCTCAGCTCAGTTCTTCAACTACAAGATCCAGGCGCTGGGGCTG
GGGGAGGACTGGCCTGGGGAGGCGATGTTGGCAGGCGGTGGGCTGAAGGTCCGGCTATTG
AAGAAAGCCCTGGAGAAGCACGCCGACAAGGAGAACCTGGTCATTCTCTTCACAGACAGC
TATGATGTGGTATTTGCCTCGGGGCCCCGAGAGCTCCTGAAGAAGTTCCGGCAGGCCAGG
AGCCAGGTGGTCTTCTCGGCCGAGGAGCTCATCTACCCGGACCGCAGGCTGGAGGCCAAT
TACCCGGTGGTGTCCGACGGCAAGAGGTTCCTGGGCTCTGGAGGCTTCATCGGTTATGCT
CCCAACCTTATCAAACTGGTGGCAGAGTGGGAAGGCCAGGACAGCGACAGCGATCAGCTC
TTTTACACCAAGATCTTCTTGGACCCAGAGAAGAGGGAGCAGATCAATATCACCCTGGAC
CACCGTTGCCGAATCTTCCAGAATTTCCATGGAGCCTTGGATGAGGTCGTGCTCAAGTTT
GAAATGGGCCAAGTGAGAGCGAGGAACCTGGCCTACGACACCCTCCCAGTCCTGATTCAT
GGCAACGGGCCCACCAAGCTGCAGCTGAACTACTTGGGCAACTACATCCCGCGCTTCTGG
ACCTTCGAGACGGGGTGCGCTGTGTGTGACGAGGGCCTGCGCAGCCTCAAGGGCATCGGG
GATGAAGCTCTGCCTGCTGTTCTGGTCGGCGTGTTCATCGAACAGCCCACCCCGTTCCTG
TCCCTGTTCTTCCAGCGGCTCTTGCTCCTCCACTACCCCCAAAAACGGTTCAGGCTTTTC
ATTCACAACCACGAGCAGCACCACAAGGCTCAGGTGGAGCAGTTCCTGGCAGAGCACGGC
GATGAGTACCAGTCTGTGAAACTGGTGGGCCCCGAGGTGCGGGTGGCCAACGCAGACGCC
AGGAACATGGGCGCGGACTTGTGCCGGCAGGACCGTGGCTGCACTTACTACTTCAGCGTG
GATGCCGACGTGGCCCTGACTGAGCCCAAAACCCTGCGGCTGCTGATCGAGCAGAACAAG
AACGTTATCACCCCATTGATGACCCGCCATGGGAGGCTGTGGTCGAACTTCTGGGGGGCA
CTGAGTGCAGATGGCTACTACGCCCGCTCCGAGGACTACGTGGACATCGTGCAGGGGCGG
CGTGTGGGTGTCTGGAATGTACCCTACATCTCAAACATCTACCTGATCAAGGGTAGCGCC
CTGCGGGCTGAGTTGCAGGAGACAGACCTGTTCCACCACAGCAAGCTGGACCCCGACATG
GCCTTCTGTGCCAACATCCGGCAGCAGGATGTGTTCATGTTCCTGACCAACCGGCACTCC
TTTGGCCACCTGCTCTCCCTGGACAGCTACCAGACCACCCACCTCCACAACGACCTCTGG
GAGGTGTTCAGCAACCCCGAGGACTGGAAGGAGAAATACATCCATGAGAACTACACCAAG
GCCTTGGCGGGGAAGATGGTGGAGATGCCTTGCCCGGACGTCTACTGGTTCCCCATCTTC
ACGGAGACGGCCTGTGATGAGCTGGTGGAAGAGATGGAGCACTACGGCCAGTGGTCCCTG
GGAGATAACAAGGACAACCGCATCCAGGGTGGCTACGAAAACGTGCCAACCATCGACATC
CACATGAACCAGATCAACTATGAGCGGGAGTGGCACAAGTTCCTGGTGGAGTACATCGCC
CCCATGACGGAGAAACTCTACCCGGGCTACTACACCAGGGCCCAATTCGACCTGGCCTTT
GTCGTCCGCTACAAGCCTGATGAGCAGCCCTCGCTGGTGCCACACCACGACGCCTCCACC
TTCACCATCAACATCGGCCTGAACCGGGTTGGAGTGGATTATGAGGGCGGGGGGTGTCGG
TTCCTGCGCTACAACTGCTCCATCCGAGCCCCACGGAAGGGCTGGACCCTGATGCACCCC
GGGCGACTCACGCACTACCACGAGGGGGTCCCCACCACCAAAGGCACCCGCTACATCGCA
GTCTCCTTCGTCGATCCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 726 |
| Molecular Weight
| 83487.0 |
| Theoretical pI
| 6.61 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
MRLLLLLAPLGWLLLAETKGDAKPEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGL
GEDWPGEAMLAGGGLKVRLLKKALEKHADKENLVILFTDSYDVVFASGPRELLKKFRQAR
SQVVFSAEELIYPDRRLEAKYPVVSDGKRFLGSGGFIGYAPNLSKLVAEWEGQDSDSDQL
FYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEVVLKFEMGQVRARNLAYDTLPVLIH
GNGPTKLQLNYLGNYIPRFWTFETGCAVCDEGLRSLKGIGDEALPAVLVGVFIEQPTPFL
SLFFQRLLRLHYPQKRLRLFIHNHEQHHKAQVEQFLAEHGDEYQSVKLVGPEVRVANADA
RNMGADLCRQDRGCTYYFSVDADVALTEPKTLRLLIEQNKNVIAPLMTRHGRLWSNFWGA
LSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRAELQETDLFHHSKLDPDM
AFCANIRQQDVFMFLTNRHSFGHLLSLDSYQTTHLHNDLWEVFSNPEDWKEKYIHENYTK
ALAGKMVEMPCPDVYWFPIFTETACDELVEEMEHYGQWSLGDNKDNRIQGGYENVPTIDI
HMNQINFEREWHKFLVEYIAPMTEKLYPGYYTRAQFDLAFVVRYKPDEQPSLVPHHDAST
FTINIALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTKGTRYIA
VSFVDP
|
| External Links |
|---|
| GenBank ID Protein
| AAC25107.1 |
| UniProtKB/Swiss-Prot ID
| O77588 |
| UniProtKB/Swiss-Prot Entry Name
| PLOD1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF054274 |
| GeneCard ID
| PLOD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
