| Identification |
|---|
| BMDB Protein ID
| BMDBP00684 |
| Secondary Accession Numbers
| None |
| Name
| 4-hydroxyphenylpyruvate dioxygenase |
| Synonyms
|
Not Available
|
| Gene Name
| HPD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Key enzyme in the degradation of tyrosine. |
| Pathways
|
- Acetoacetate and fumarate from L-phenylalanine: step 3/6
- Amino-acid degradation
- L-phenylalanine degradation
- Phenylalanine and Tyrosine Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| 4-Hydroxyphenylpyruvic acid + Oxygen → Homogentisic acid + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| HPD |
| Gene Sequence
|
>1182 bp
ATGACGACTTACAGCGACAAAGGAGAGAAGCCTGAAAGAGGCCGATTCCTCCACTTTCAC
TCTGTGACCTTCTGGGTTGGCAATGCCAAGCAGGCTGCGTCATATTACTGCAGTAAGCTG
GGCTTTGAGCCCCTAGCCTACAAGGGCCTGGAGACCGGTTCCCGGGAAGTGGTGAGCCAT
GTGGTCAAGCAAGGGCAGATCGTGTTCGTCTTCTCCTCTGCCCTCAACCCCTGGAACAAA
GAGATGGGCGATCACCTGGTGAAACACGGCGATGGAGTGAAGGACATTGCGTTCGAGGTG
GAGGACTGTGACTACATTGTGCAGAAAGCCCGGGAACGAGGCGCCAAGATTGTGCGGGAG
CCTTGGGTAGAGCAAGATAAGCTTGGGAAGGTGAAGTTTGCTGTGCTACAGACGTATGGG
GACACGACACACACCCTGGTGGAGAAGATGAACTATACTGGCCGGTTCCTGCCTGGATTC
GAGGCACCACCATTCATGGACCCCCAACTTTCCAAGCTGCCCAGCTGCAGTCTCGAGATA
ATCGATCACATTGTGGGAAACCAGCCTGATCAAGAGATGGTGTCTGCCTCTGAATGGTAC
CTGAAGAACTTGCAGTTCCACCGTTTCTGGTCCGTGGATGACACGCAGGTGCACACGGAG
TACAGCTCTCTGCGGTCCGTCGTGGTGGCCAATTATGAGGAATCCATCAAGATGCCCATT
AATGAGCCAGCACCGGGCAAGAAGAAGTCCCAGATCCAGGAATATGTGGACTATAACGGG
GGCGCTGGGGTCCAGCACATTGCTCTCAAGACCAAAGACATCATCACAGCAATTCGCCAC
TTGAGAGAGAGAGGCGTGGAGTTTTTGGCTGTTCCATCCACATACTACAAACAACTGCGG
GAGAAGCTCAAGATGGCCAAGATCCGGGTGAAGGAGAATATTGATATCCTAGAGGAGCTG
AAGATCCTGGTAGACTACGACGAGAAAGGCTACCTCCTGCAGATTTTCACCAAACCCATG
CAGGACCGGCCCACGCTCTTCCTGGAAGTCATTCAGCGCCACAATCACCAGGGTTTTGGA
GCCGGCAACTTCAACTCACTGTTCAAGGCCTTCGAGGAGGAGCAGGACCTGCGAGGCAAC
CTCACCGACATGGAGCCCAATGGGGTTGTGTCCGGCATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 393 |
| Molecular Weight
| 44963.0 |
| Theoretical pI
| 6.71 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>4-hydroxyphenylpyruvate dioxygenase
MTTYSDKGEKPERGRFLHFHSVTFWVGNAKQAASYYCSKLGFEPLAYKGLETGSREVVSH
VVKQGQIVFVFSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIVRE
PWVEQDKLGKVKFAVLQTYGDTTHTLVEKMNYTGRFLPGFEAPPFMDPQLSKLPSCSLEI
IDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSVVVANYEESIKMPI
NEPAPGKKKSQIQEYVDYNGGAGVQHIALKTKDIITAIRHLRERGVEFLAVPSTYYKQLR
EKLKMAKIRVKENIDILEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFG
AGNFNSLFKAFEEEQDLRGNLTDMEPNGVVSGM
|
| External Links |
|---|
| GenBank ID Protein
| AAX08766.1 |
| UniProtKB/Swiss-Prot ID
| Q5EA20 |
| UniProtKB/Swiss-Prot Entry Name
| HPPD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT020749 |
| GeneCard ID
| HPD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
