| Identification |
|---|
| BMDB Protein ID
| BMDBP00685 |
| Secondary Accession Numbers
| |
| Name
| Arachidonate 15-lipoxygenase |
| Synonyms
|
Not Available
|
| Gene Name
| ALOX15 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in arachidonate 12-lipoxygenase activity |
| Specific Function
| Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. |
| Pathways
|
- Hydroperoxy eicosatetraenoic acid biosynthesis
- Lipid metabolism
|
| Reactions
|
| Arachidonic acid + Oxygen → 15(S)-HPETE |
details
|
| Arachidonic acid + Oxygen → 8(S)-HPETE |
details
|
| Arachidonic acid + Oxygen → 12(R)-HPETE |
details
|
| Arachidonic acid + Oxygen → 12(S)-HPETE |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| ALOX15 |
| Gene Sequence
|
>1992 bp
ATGGGTCTCTACCGCGTCCGCGTGTCCACCGGGTCCTCGTTCTGCGCGGGCTCCAATAAC
CAGGTGCACCTGTGGCTGGTCGGCGAGCACGGGGAGGCGGCGCTCGGGTGGGCCGTGCGG
CCGGCGAGGGGGAAGGAGGTGGAATTCCAGGTGGACGTGTCCGAGTACCTGGGGCGGCTG
CTGTTCGTGAAATTGCGCAAACGGCACCTCCTCTCGGATGATGCGTGGTTCTGCAACTGG
ATCTCCGTGCAGGGCCCCGGGGCCAGTGGGAACGAGTTCAGGTTCCCGTGCTATCGCTGG
GTGGAGGGCGATGGCATCCTGAGCCTGCCCGAGGGCACCGGTCGCACTGTGGTCGATGAC
CCTCAAGGTCTGTTCAAGAAACACAGGGAAGAGGAGCTGGCAGAGAGAAGGAAGCTGTAC
CGGTGGGGTAACTGGAAGGACGGGTTAATTCTGAATATAGCTGGGGCCACAATAAATGAC
CTTCCTGTAGATGAGAGATTTCTAGAGGACAAAAGAATTGACTTTGAGGCCTCACTGACC
AAGGGGCTGGCAGACCTAGCCATCAAAGACTCTTTAAACATTCTGACTTGCTGGAAAAGT
CTGGATGACTTCAACAGGATTTTCTGGTGTGGCCAGAGCAAGCTGGCTGAGCGGGTGCGG
GATTCCTGGAAGGAGGATGCCTTATTTGGGTACCAGTTTCTCAACGGCACCAACCCCATG
TTGCTGAGACGCTCCGTTCGCCTTCCTGCCCGCCTGGAGTTTCCTCCAGGGATGGGGGAG
CTGCAGGCCGAGCTGGAGAAGGAGCTCCAGCAAGGCACGCTATTTGAAGCTGACTTCTCC
TTGCTGATGGGGATCAAGGCCAACGTCATCCTGTGTACCCAGCAGTATGTGGCTGCCCCT
CTGGTTATGCTGAAACTGCAGCCCGATGGGAAACTCTTACCCATGGCCATCCAGCTCCAA
CTGCCACACAAGGGGTCCCCACCACCACCGCTTTTCCTGCCCACGGATCCCCCGATGACC
TGGCTCCTGGCCAAATGCTGGGTCCGGAGCTCTGACTTCCAGCTTCACGAGCTGCACTCT
CATCTCCTGAGGGGACACTTGGTGGCTGAGGTCATCGCTGTGGCCACCATGAGGTGCCTT
CCGTCTATACATCCTATGTTCAAGCTTCTCATTCCGCACCTGCGATACACCATGGAAATT
AACATCCGGGCCAGGACTGGGCTGGTCTCTGACTCGGGAGTCTTCGACCAGGTGGTGAGC
ACAGGTGGGGGCGGCCATGTGGAGCTGCTCCAGCGAGCAGGAGCCTTTCTAACCTATAGC
TCCTTCTGTCCCCCTGATGACCTGGCTGACCGGGGGCTCCTGGGAGTCAAGTCTTCTTTC
TATGCCCAAGATGCCCTGAGGCTCTGGGAAATTCTCTCTCGCTACGTGGAGGGGATTGTG
AGTCTCCACTATAAGACGGACGAGTCTGTGAGAGACGACATTGAGCTGCAGGCCTGGTGT
CGAGATATCACTGAGATTGGGCTGCTGGGTGCCCAGGACCGAGGGTTTCCCGTCACCCTA
CAGTCCAAGGACCAGCTTTGCCACTTTGTGACCATGTGTATCTTCACCTGCACTGGTCAG
CACTCCTCCACTCACCTGGGCCAGCTGGACTGGTACTCTTGGGTCCCTAACGCACCCTGC
ACAATGCGGCTGCCCCCACCGACCACCAAGGATGTGACACTGGAGAAAGTGATGGCAACA
CTGCCGAACTTCCATCAGGCTTCTCTCCAGATGTCCATCACTTGGCAACTGGGCAGACGC
CAGCCCATCATGGTGGCTCTGGGTCAGCATGAGGAAGAGTACTTCTCAGGCCCTGAGCCC
AAGGCTGTGCTAAAGAAGTTCAGGGAGGAGCTGGCTGCCCTGGAAAAAGACATAGAGATC
CGGAATGCCCAGCTGGACTGGCCCTACGAATACCTGCGGCCCAGCCTGGTGGAAAACAGC
GTGGCCATATGA
|
| Protein Properties |
|---|
| Number of Residues
| 663 |
| Molecular Weight
| 75124.0 |
| Theoretical pI
| 6.51 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arachidonate 12-lipoxygenase, 12S-type
MGLYRVRVSTGSSFCAGSNNQVHLWLVGEHGEAALGWAVRPARGKEVEFQVDVSEYLGRL
LFVKLRKRHLLSDDAWFCNWISVQGPGASGNEFRFPCYRWVEGDGILSLPEGTGRTVVDD
PQGLFKKHREEELAERRKLYRWGNWKDGLILNIAGATINDLPVDERFLEDKRIDFEASLT
KGLADLAIKDSLNILTCWKSLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGTNPM
LLRRSVRLPARLEFPPGMGELQAELEKELQQGTLFEADFSLLMGIKANVILCTQQYVAAP
LVMLKLQPDGKLLPMAIQLQLPHKGSPPPPLFLPTDPPMTWLLAKCWVRSSDFQLHELHS
HLLRGHLVAEVIAVATMRCLPSIHPMFKLLIPHLRYTMEINIRARTGLVSDSGVFDQVVS
TGGGGHVELLQRAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEILSRYVEGIV
SLHYKTDESVRDDIELQAWCRDITEIGLLGAQDRGFPVTLQSKDQLCHFVTMCIFTCTGQ
HSSTHLGQLDWYSWVPNAPCTMRLPPPTTKDVTLEKVMATLPNFHQASLQMSITWQLGRR
QPIMVALGQHEEEYFSGPEPKAVLKKFREELAALEKDIEIRNAQLDWPYEYLRPSLVENS
VAI
|
| External Links |
|---|
| GenBank ID Protein
| AAC41614.1 |
| UniProtKB/Swiss-Prot ID
| P27479 |
| UniProtKB/Swiss-Prot Entry Name
| LOX15_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M62516 |
| GeneCard ID
| ALOX15 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
