<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:23:33 UTC</creation_date>
  <update_date>2020-05-20 21:07:34 UTC</update_date>
  <accession>BMDBP00689</accession>
  <secondary_accessions>
    <accession>BMDBP03042</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>DPYD</gene_name>
  <general_function>Amino acid transport and metabolism</general_function>
  <specific_function>Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.</specific_function>
  <pathways>
    <pathway>
      <name>Amino-acid biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Beta-alanine biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000076</accession>
      <name>Dihydrouracil</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000217</accession>
      <name>NADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000221</accession>
      <name>NADPH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000300</accession>
      <name>Uracil</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000692</accession>
      <name>Iron</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001248</accession>
      <name>FAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000262</accession>
      <name>Thymine</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000079</accession>
      <name>Dihydrothymine</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>3</chromosome_location>
    <locus/>
    <gene_sequence>&gt;3078 bp
ATGGCCCCTGTGCTAAGCAAGGACGTGGCGGATATCGAGAGTATCCTGGCTTTAAATCCT
CGAACACAGTCTCGTGCAACTCTGCGTTCCACTTTGGCCAAGAAATTAGACAAGAAACAT
TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGCGAGAAGCTGGAGAATAATTTTGAT
GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG
AAATGTGCAGATGCCCCCTGTCAGAAGAGCTGTCCAACAAATCTAGATATCAAATCGTTC
ATCACAAGTATCTCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC
CCACTTGGTCTGACCTGTGGAATGGTATGCCCCACCTCTGATCTTTGTGTAGGTGGATGT
AATTTGTATGCCACTGAAGAGGGACCAATTAATATTGGTGGATTGCAGCAATATGCTACT
GAGGTATTCAAAGCAATGAATATCCCACAAATCAGGAATCCTTCTCTGCCTCCCCCAGAA
AAAATGCCTGAAGCCTATTCTGCAAAGATTGCTCTTTTGGGTGCTGGGCCTGCAAGTATA
AGTTGTGCTTCGTTCTTGGCTCGATTAGGCTACAATGACATCACTATATTTGAAAAACAA
GAATACGTTGGTGGTATAAGTACTTCTGAAATCCCTCAGTTCCGGCTGCCATATGATGTA
GTAAATTTTGAGATTGAGCTTATGAAGGACCTTGGTGTAAAGATAATTTGTGGTAAAAGC
CTTTCAGTGAATGACATTACTCTTAGTACTTTGAAAGAAGAAGGGTACAAAGCTGCTTTC
ATTGGGATAGGTTTGCCAGAACCCAAGAAGGATCACATCTTCCAAGGCCTGACACAGGAC
CAGGGGTTTTACACTTCCAAAGACTTTCTGCCTCTTGTAGCCAAAAGCAGTAAAGCAGGA
ATGTGCGCCTGTCACTCTCCATTGCTGTCGATACGGGGAACCGTGATTGTACTCGGAGCT
GGAGACACAGCTTTCGACTGTGCAACATCCGCTTTACGTTGTGGAGCCCGCCGAGTGTTC
ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGGTGGAGCTTGCT
AGAGAAGAAAAATGTGAATTTTTGCCTTTCTTGTCTCCACGGAAGGTTATAGTAAAAGGT
GGGAGAATTGTTGCCATGCAATTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT
GAAGATGGAGATCAGATAGCCTGTCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGCTCA
GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGAT
CTCCCAGAAGTAGATCCAGAAACTATGCAAACCAGTGAGCCATGGGTGTTTGCAGGTGGT
GATGTGGTTGGTATAGCCAACACTACAGTGGAAGCCGTGAATGATGGAAAGCAAGCCTCT
TGGTACATTCACAGATATATACAGTCACAATATGGAGCTTCAGTTTCTGCTAAGCCCGAA
CTCCCCCTGTTTTATACTCCCATTGATCTGGTGGACATTAGTGTGGAAATGGCTGCATTG
AAGTTTACAAATCCTTTTGGTCTTGCCAGTGCAACTCCAACTACCAGTTCGTCAATGATT
CGAAGAGCTTTTGAAGCTGGATGGGCCTTTGCTCTGACCAAAACTTTCTCTCTTGATAAG
GATATAGTGACAAATGTTTCACCCAGAATCATCCGGGGGACCACCTCTGGCCCCATGTAT
GGCCCTGGACAAAGCTCTTTCCTGAATATTGAGCTCATCAGTGAAAAAACGGCTGCATAT
TGGTGTCAAAGTGTCACTGAACTAAAAGCCGACTTTCCAGACAATATTGTGATTGCTAGC
ATCATGTGCAGTTACAACAGAAATGACTGGATGGAACTCTCCAGAAAGGCTGAGGCTTCT
GGAGCAGACGCCCTGGAGTTAAATTTATCGTGTCCGCATGGCATGGGAGAAAGAGGAATG
GGTCTGGCTTGTGGACAGGATCCAGAGCTGGTGCGGAACATCTGTCGCTGGGTTAGGCAA
GCTGTTCGGATTCCTTTTTTTGCCAAGTTGACCCCAAATGTCACTGATATTGTAAGCATA
GCCAGAGCTGCAAAGGAAGGTGGGGCAAATGGTGTTACAGCTACCAACACTGTCTCAGGT
CTCATGGGATTAAAAGCTGATGGCACACCCTGGCCAGCAGTGGGCCGTGAGAAGCGGACT
ACATACGGCGGAGTGTCCGGCACAGCCATCAGACCTATTGCTTTGAGAGCTGTGACCACC
ATTGCTCGTGCTTTGCCTGAATTTCCCATTTTGGCCACTGGTGGAATTGACTCAGCTGAA
AGTGGTCTTCAGTTTCTCCACGGTGGTGCTTCGGTGCTCCAGGTATGCAGTGCTATTCAA
AATCAGGATTTCACTATCATCCAAGACTACTGCACTGGCCTCAAAGCCTTGCTTTATCTG
AAAAGCATTGAAGAACTACAGGACTGGGATGGGCAGAGTCCAGCCACGAAGAGTCACCAG
AAAGGGAAACCAGTCCCTTGTATTGCTGAACTTGTGGGAAAGAAACTGCCAAGCTTTGGA
CCTTATCTTGAGAAGTGCAAGAAAATCATAGCAGAGGAAAAGTTGAGACTGAAAAAAGAA
AATGTGACCGTTCTACCACTTGAAAGAAACCATTTTATCCCAAAAAAACCTATTCCTTCT
GTTAAGGATGTGATTGGAAAAGCTCTGCAGTACCTTGGAACATATGGTGAACTGAACAAC
ACAGAGCAGGTTGTGGCTGTGATCGATGAAGAGATGTGTATCAACTGTGGCAAATGCTAC
ATGACCTGTAATGACTCTGGCTACCAGGCTATCCAGTTTGATCCTGAAACCCACCTGCCC
ACCGTTACTGACACTTGTACAGGCTGTACCCTGTGTCTCTCCGTCTGCCCTATTATCGAC
TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCTTGCCCTTGGCT
GTGAATCCTGTGTCTTAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>1025</residue_number>
    <molecular_weight>111697.0</molecular_weight>
    <theoretical_pi>7.32</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>874-897</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Dihydropyrimidine dehydrogenase [NADP+]
MAPVLSKDVADIESILALNPRTQSRATLRSTLAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQYATEVFKAMNIPQIRNPSLPPPE
KMPEAYSAKIALLGAGPASISCASFLARLGYNDITIFEKQEYVGGISTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNDITLSTLKEEGYKAAFIGIGLPEPKKDHIFQGLTQD
QGFYTSKDFLPLVAKSSKAGMCACHSPLLSIRGTVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEVELAREEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDGDQIACLKADVVISAFGSVLSDPKVKEALSPIKFNRWDLPEVDPETMQTSEPWVFAGG
DVVGIANTTVEAVNDGKQASWYIHRYIQSQYGASVSAKPELPLFYTPIDLVDISVEMAAL
KFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNRNDWMELSRKAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKADGTPWPAVGREKRTTYGGVSGTAIRPIALRAVTT
IARALPEFPILATGGIDSAESGLQFLHGGASVLQVCSAIQNQDFTIIQDYCTGLKALLYL
KSIEELQDWDGQSPATKSHQKGKPVPCIAELVGKKLPSFGPYLEKCKKIIAEEKLRLKKE
NVTVLPLERNHFIPKKPIPSVKDVIGKALQYLGTYGELNNTEQVVAVIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPLA
VNPVS</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAB40985.1</genbank_protein_id>
  <uniprot_id>Q28007</uniprot_id>
  <uniprot_name>DPYD_BOVIN</uniprot_name>
  <pdb_ids>
    <pdb_id>1GTE</pdb_id>
  </pdb_ids>
  <genbank_gene_id>U20981</genbank_gene_id>
  <genecard_id>DPYD</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
