| Identification |
|---|
| BMDB Protein ID
| BMDBP00698 |
| Secondary Accession Numbers
| |
| Name
| Purine nucleoside phosphorylase |
| Synonyms
|
Not Available
|
| Gene Name
| PNP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. |
| Pathways
|
- Purine Metabolism
- Purine nucleoside salvage
|
| Reactions
|
| Guanosine + Hydrogen phosphate → Guanine + Ribose 1-phosphate |
details
|
| Deoxyguanosine + Hydrogen phosphate → Guanine + Deoxyribose 1-phosphate |
details
|
| Xanthosine + Hydrogen phosphate → Xanthine + Ribose 1-phosphate |
details
|
| Inosine + Hydrogen phosphate → Hypoxanthine + Ribose 1-phosphate |
details
|
| Deoxyinosine + Hydrogen phosphate → Hypoxanthine + Deoxyribose 1-phosphate |
details
|
| Adenosine + Hydrogen phosphate → Adenine + Ribose 1-phosphate |
details
|
| Deoxyadenosine + Hydrogen phosphate → Adenine + Deoxyribose 1-phosphate |
details
|
| Niacinamide + Ribose-1-arsenate → Nicotinamide riboside + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| PNP |
| Gene Sequence
|
>870 bp
ATGGCGAATGGATATACATATGAAGATTATCAAGACACTGCAAAATGGCTTTTGTCTCAT
ACCGAACAGCGATCTCAAGTGGCAGTGATCTGTGGTTCTGGGTTAGGAGGTCTGGTTAAC
AAATTGACTCAAGCCCAGACCTTTGACTACAGTGAAATACCAAACTTTCCAGAAAGTACA
GTGCCAGGTCATGCTGGTCGACTGGTGTTTGGGATCTTGAATGGCAGAGCCTGTGTGATG
ATGCAGGGCAGGTTCCACATGTATGAAGGCTATCCGTTTTGGAAGGTGACATTCCCAGTG
AGGGTTTTCCGGCTTCTGGGTGTGGAGACCCTAGTGGTCACCAACGCAGCTGGAGGGCTC
AACCCCAACTTTGAGGTTGGCGATATCATGCTGATCCGTGATCACATCAACCTACCTGGT
TTCAGTGGTGAGAACCCTCTCAGAGGGCCCAATGAGGAAAGGTTTGGAGTTCGTTTCCCT
GCCATGTCTGATGCCTACGACCGGGATATGAGGCAGAAAGCTCACAGTACCTGGAAACAA
ATGGGGGAGCAAAGAGAGTTACAGGAAGGCACCTACGTGATGTTGGGGGGTCCCAATTTT
GAGACTGTGGCAGAGTGTCGCCTGCTGCGGAATCTAGGGGCAGATGCTGTTGGCATGAGC
ACAGTACCAGAAGTTATAGTCGCAAGACACTGTGGACTTCGAGTCTTTGGCTTCTCACTC
ATCACAAACAAGGTCATCATGGATTATGAAAGCCAGGGGAAGGCCAATCATGAGGAAGTA
CTAGAGGCTGGGAAGCAAGCTGCACAGAAATTAGAGCAGTTTGTCTCCCTTCTTATGGCT
AGCATTCCAGTGTCAGGGCACACCGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 289 |
| Molecular Weight
| 32037.0 |
| Theoretical pI
| 6.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Purine nucleoside phosphorylase
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
|
| External Links |
|---|
| GenBank ID Protein
| AAX46392.1 |
| UniProtKB/Swiss-Prot ID
| P55859 |
| UniProtKB/Swiss-Prot Entry Name
| PNPH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021545 |
| GeneCard ID
| PNP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
