| Identification |
|---|
| BMDB Protein ID
| BMDBP00702 |
| Secondary Accession Numbers
| |
| Name
| Acidic mammalian chitinase |
| Synonyms
|
Not Available
|
| Gene Name
| CHIA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cation binding |
| Specific Function
| Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| CHIA |
| Gene Sequence
|
>1419 bp
ATGGCAAAACTTATTTTCCTCACAGGTCTGGCCTTTCTGCTGAATGCTCAGCTAGGTTCT
GCCTACCAGCTGGTATGCTACTTCTCTAACTGGGCCCAGTACCGTCCAGGCCTGGGAAGC
TTCAAGCCTGACAACATCGACCCCTGCCTCTGCACTCACCTGATCTATGCCTTCGCTGGG
ATGAGTAACAGTGAGATCACCACCATTGAATGGAATGATGTGGCTCTCTATAGTTCTTTC
AATGACCTGAAAAAAAAGAACAGCCAGCTGAAAATTCTCCTGGCCATTGGAGGCTGGAAC
TTTGGAACTGCCCCTTTCACTGCTATGGTTGCCACTCCGGAGAACCGCAAGACTTTCATT
TCTTCAGTCATCAAATTCCTACACCAGTATGGATTTGACGGGCTGGATTTTGATTGGGAG
TACCCTGGCTTTCGTGGAAGCCCTTCTCAGGACAAGCATCTCTTCACTGTCTTAGTGCAG
GAAACACGTGAAGCTTTTGAACAGGAAGCCAAGCAAACCAACAAGCCCAGGCTGCTGGTC
ACCGCTGCAGTAGCTGCTGGCATCTCTAATATCCAGGCTGGCTATGAGATTCCCCAGCTA
TCCCAGTACCTGGACTTCATCCATGTCATGACCTATGACTTCCATGGCTCCTGGGAAGGC
TACACAGGAGAGAACAGCCCTCTCTACAAATACCCAACTGACACTGGCAGCAATACTTAC
CTCAATGTGGAATACGCCATGAACTACTGGAAGAAAAATGGGGCCCCGGCTGAGAAGCTC
ATCATTGGATTCCCTGCCTACGGACACAATTTCATCCTAAGAGACGCTTCCAACAATGGT
ATCGGTGCCCCCACTTCTGGAGCTGGTCCTGCCGGGCCCTACACCAGGGAGGCTGGGTTC
TGGGCCTACTATGAGATCTGTGCCTTCCTGAAAGATGGAGCCACTGAGGCATGGGATGAC
TCTCAGAATGTGCCCTATGCCTACAAGGGCACTGAGTGGGTTGGTTATGACAATGTTAAC
AGCTTCAGAATCAAGGCTCAGTGGCTTAAGGAGAACAACTTTGGAGGTGCCATGGTCTGG
GCCATTGACCTGGATGATTTCACAGGCACTTTCTGCAACCAGGGCAAGTTCCCCCTGATA
AATACCTTGAAGGATGCTCTTGGCCTGAAGAGTGCAACCTGTAATGCCTCCACGCAGTCC
AGTGAGCCCAACAGCAGTCCTGGAAACGAAAGTGGGAGTGGAAATAAGAGCAGCAGCTCC
GAGGGTAGAGGATACTGTGCTGGCAAAGCTGATGGCCTCTACCCAGTGGCGGATAACAGA
AATGCCTTCTGGAACTGCGTAAATGGAATCACATACAAACAGAATTGCCTGACTGGGCTT
GTCTTTGACACCAGCTGTCACTGCTGCAACTGGGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 472 |
| Molecular Weight
| 52129.0 |
| Theoretical pI
| 5.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acidic mammalian chitinase
MAKLIFLTGLAFLLNAQLGSAYQLVCYFSNWAQYRPGLGSFKPDNIDPCLCTHLIYAFAG
MSNSEITTIEWNDVALYSSFNDLKKKNSQLKILLAIGGWNFGTAPFTAMVATPENRKTFI
SSVIKFLHQYGFDGLDFDWEYPGFRGSPSQDKHLFTVLVQETREAFEQEAKQTNKPRLLV
TAAVAAGISNIQAGYEIPQLSQYLDFIHVMTYDFHGSWEGYTGENSPLYKYPTDTGSNTY
LNVEYAMNYWKKNGAPAEKLIIGFPAYGHNFILRDASNNGIGAPTSGAGPAGPYTREAGF
WAYYEICAFLKDGATEAWDDSQNVPYAYKGTEWVGYDNVNSFRIKAQWLKENNFGGAMVW
AIDLDDFTGTFCNQGKFPLINTLKDALGLKSATCNASTQSSEPNSSPGNESGSGNKSSSS
EGRGYCAGKADGLYPVADNRNAFWNCVNGITYKQNCLTGLVFDTSCHCCNWA
|
| External Links |
|---|
| GenBank ID Protein
| BAB71805.1 |
| UniProtKB/Swiss-Prot ID
| Q95M17 |
| UniProtKB/Swiss-Prot Entry Name
| CHIA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB051629 |
| GeneCard ID
| CHIA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
