| Identification |
|---|
| BMDB Protein ID
| BMDBP00706 |
| Secondary Accession Numbers
| None |
| Name
| N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase |
| Synonyms
|
Not Available
|
| Gene Name
| NAGPA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetylglucosamine-1-phosphodiester alpha- |
| Specific Function
| Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases. |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| NAGPA |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 527 |
| Molecular Weight
| 57223.0 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
MASSMGRFLLFFIALRGFLLEASGDFGSGASRDDDVLLPYSRARARLARDCTRVHAGRLE
HHESWPPAAQTAGAHRPSVRTFVSYFADRAVPGHLTRAPEPLRTFSVLEPGGPGGCASKR
RATVEETARPSGCTVAQNGGFFRMETGECLGNVVSGGRRVSSAGGLQNAQFGIRRDGTLV
TGYLSEEEVLDTENPFVQLLSGVVWLIRNGSIYINESQAAECEETQETGSFNRFVNVISA
RTAVGHDRKGQLVLLHVDGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTL
ASYPSDHCQDNMWRCPRRVSTVVCVHEPRCQPPDCSGHGTCMEGRCQCTGHFWRGAACDK
LDCGPANCSQHGLCTETGCRCEAGWTGSNCSEECPLGWYGPGCQSPCKCEHQCPCDPQTG
NCSVNWSPTLSSLFSRVKECFPPPEVTVQAEELSLLTRTTWLAITLALAFLLLISTAANV
SLFLGSRAARRRHLDGAYVYHPLQEVNGEHPAAEKEQLGDSSNPFKD
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P68827 |
| UniProtKB/Swiss-Prot Entry Name
| NAGPA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| NAGPA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
