| Identification |
|---|
| BMDB Protein ID
| BMDBP00713 |
| Secondary Accession Numbers
| None |
| Name
| Retinol dehydrogenase 8 |
| Synonyms
|
Not Available
|
| Gene Name
| RDH8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. |
| Pathways
|
- Androgen and Estrogen Metabolism
- Estrone Metabolism
- Retinol Metabolism
|
| Reactions
|
| Estradiol + NADP → Estrone + NADPH |
details
|
| 11-cis-Retinaldehyde + NADP → Retinal + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| RDH8 |
| Gene Sequence
|
>939 bp
ATGGCTGATGCACCCCGGACTGTACTCATCTCAGGATGCTCCTCTGGGATCGGCTTGGAG
CTGGCAGTGCAGCTGGCTCATGACCCCAGGCAGCGCTACCAGGTGGTGGCCACCATGAGG
GACCTGGGAAAGAAGGGGACACTGGAGACAGCCGCTGGGGAGGCTCTGGGTCAGACCCTC
ACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCAGTGGCCCAGTGTCTCAACTGCATC
CAGGGAGGGGAAGTGGACGTGCTGGTGAATAATGCTGGAGTGGGCCTGGTGGGGCCCTTG
GAAGGGCTCAGCCTAGCTGCCATGCAGAACGTCTTTGATACCAACTTTTTTGGGGCTGTC
CGGCTGGTCAAAGCTGTGCTTCCCAGCATGAAGAGGAGGCGACAGGGCCACATCGTGGTG
GTCAGCAGTGTCATGGGGCTGCAGGGTGTCGTGTTCAACGAAGTCTACGCGGCCTCCAAG
TTTGCCATGGAGGGGTTCTTCGAAAGTCTGGCTGTCCAGCTGCTACAGTTCAACATCTTC
ATCTCCCTGGTGGAGCCAGGCCCGGTTGTCACAGAATTTGAGGGCAAGCTCCTAGAGCAG
GTTTCCACAGCCGAGTTCCCAGGCACCGACCCTGACACCCTGAGCTACTTTCGAGATCTG
TACCTCCCAGCCTCCAGGGAGCTCTTTCACAACGTGGGACAGAGCCCACAGGATGTAGCC
AAGGTCATCGTCAAGGTCATCGGCTCGGCCAGACCACCCTTGCGCCGACGGACCAACACC
CGCTACACTCCACTGATCGCACTCAAGGCCATGGACCCCTCCGGCAGCCTGTATGTGCGA
ACCTCCCACTGCCTGCTCTTCCGCTGGCCACGCCTCCTCAACCTTGGCCTTCGGTGCCTG
GCCTGCAGCTGCTTCCGCACCCCAGTGTGGCCCCGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 312 |
| Molecular Weight
| 33956.0 |
| Theoretical pI
| 8.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Retinol dehydrogenase 8
MADAPRTVLISGCSSGIGLELAVQLAHDPRQRYQVVATMRDLGKKGTLETAAGEALGQTL
TVAQLDVCSDESVAQCLNCIQGGEVDVLVNNAGVGLVGPLEGLSLAAMQNVFDTNFFGAV
RLVKAVLPSMKRRRQGHIVVVSSVMGLQGVVFNEVYAASKFAMEGFFESLAVQLLQFNIF
ISLVEPGPVVTEFEGKLLEQVSTAEFPGTDPDTLSYFRDLYLPASRELFHNVGQSPQDVA
KVIVKVIGSARPPLRRRTNTRYTPLIALKAMDPSGSLYVRTSHCLLFRWPRLLNLGLRCL
ACSCFRTPVWPR
|
| External Links |
|---|
| GenBank ID Protein
| AAF63161.1 |
| UniProtKB/Swiss-Prot ID
| Q9N126 |
| UniProtKB/Swiss-Prot Entry Name
| RDH8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF229846 |
| GeneCard ID
| RDH8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
