| Identification |
|---|
| BMDB Protein ID
| BMDBP00714 |
| Secondary Accession Numbers
| None |
| Name
| Lecithin retinol acyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| LRAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatidylcholine-retinol O-acyltransfera |
| Specific Function
| Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938, PubMed:2722792). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). |
| Pathways
|
- Cofactor metabolism
- Retinol Metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| LRAT |
| Gene Sequence
|
>693 bp
ATGAAGAACCCAATGCTGGAGGCCGTGTCGCTCGTGCTGGAGAAGCTACTCTTCATCTCC
TACTTCAAGTTCTTCAGTTCAGGCGCCCCGGGGCAAGACAAGGCGGGGAACACTTTATAT
GAGATCAGCTCTTTTCTCCGCGGTGACGTGCTGGAGGTGCCTCGGACCCACCTGACGCAC
TATGGCATCTACCTGGGCGACAACCGTGTTGCCCACATGATGCCCGATATCCTGTTGGCC
CTGACTGACGACAAAGGGCGCACGCAGAAAGTGGTCTCCAACAAGCGTCTCATCCTAGGC
GTCATTGGCAGGGTGGCCAGCATCCGCGTGGACACCGTGGAGGACTTCGCCTACGGAGCC
GAGATCCTGGTGAATCACCTGGACAGGTCCCTCAAGAAGAAGGCACTGCTCAACGAGGAG
GTGGCGCAGAGGGCAGAGAAGCTGCTGGGCATAACTCCCTACAGCCTACTTTGGAACAAC
TGCGAGCATTTCGTCACCTACTGCAGATATGGCACCCCGATTAGTCCCCAGGCCGACAAG
TTTTGTGAGAATGTGAAGATAATTATTCGTGATCAGAGAAGCGTCCTTGCTTCTGCAGTC
TTGGGATTGGCGTCTATATTCTGTCTGGGCTTGACATCATATACCACTCTTCCTGCAATT
TTTATTCCATTCTTATTATGGATGGCTGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 230 |
| Molecular Weight
| 25701.0 |
| Theoretical pI
| 8.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Lecithin retinol acyltransferase
MKNPMLEAVSLVLEKLLFISYFKFFSSGAPGQDKAGNTLYEISSFLRGDVLEVPRTHLTH
YGIYLGDNRVAHMMPDILLALTDDKGRTQKVVSNKRLILGVIGRVASIRVDTVEDFAYGA
EILVNHLDRSLKKKALLNEEVAQRAEKLLGITPYSLLWNNCEHFVTYCRYGTPISPQADK
FCENVKIIIRDQRSVLASAVLGLASIFCLGLTSYTTLPAIFIPFLLWMAG
|
| External Links |
|---|
| GenBank ID Protein
| AAK08701.1 |
| UniProtKB/Swiss-Prot ID
| Q9BGL2 |
| UniProtKB/Swiss-Prot Entry Name
| LRAT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF275344 |
| GeneCard ID
| LRAT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
