1.0 2018-05-07 22:23:40 UTC 2020-05-20 21:07:32 UTC BMDBP00715 Enzyme RDH5 Lipid transport and metabolism Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:7544779, PubMed:7836368, PubMed:9654122). Has no activity towards all-trans retinal (PubMed:9654122). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). Cofactor metabolism Retinol Metabolism SMP0087260 BMDB0000305 Vitamin A BMDB0001358 Retinal BMDB0001487 NADH 5 >957 bp ATGTGGCTGCCTCTGCTGCTGGGTGTCTTGCTCTGGGCAGCACTGTGGTTGCTCAGGGAC CGGCAGTGCCTGCCAGCCAGCGATGCCTTTATCTTCATCACCGGCTGTGACTCGGGCTTT GGGCGGCTCCTTGCTCTGAGGCTGGACCAGAGAGGCTTCCGAGTACTGGCCAGCTGCCTG ACACCCTCGGGGGCGGAGGACCTCCAGCGGGTCGCCTCCTCCCGCCTCCACACCACCCTG CTGGATGTCACAGATCCCCAGAGCATCCGGCAGGCAGTCAAGTGGGTGGAAACGCATGTT GGGGAAGCAGGGCTTTTTGGTCTGGTGAATAATGCTGGTGTGGCTGGCATCATTGGTCCC ACCCCATGGCAGACGCGGGAGGACTTCCAGCGGGTGCTGAATGTGAACACGCTGGGTCCC ATCGGGGTCACCCTCGCCCTGCTGCCCCTGCTGCTGCAGGCCCGGGGCCGAGTGATCAAC ATCACCAGTGTCCTTGGCCGTCTGGCAGCCAATGGAGGGGGCTACTGCGTCTCCAAGTTT GGCCTGGAGGCCTTCTCTGACAGCCTGAGGCGAGATGTGGCTCCTTTTGGGGTACGGGTC TCTATCGTGGAACCTGGCTTCTTCCGAACCCCTGTGACAAACCTGGAAACTTTGGAGGAC ACCCTGCAGGCCTGCTGGGCACGGCTGCCTCCAGCCACACAGGCCCTCTATGGGGAGGCC TTCCTCACCAAATACCTGAGAGTGCAGCAACGTATCATGAACATGATCTGTGATCCGGAC CTGGCCAAGGTGAGCAGGTGCCTGGAGCATGCCCTAACTGCCCGTCACCCCAGAACCCGC TACAGCCCAGGCTGGGATGCCAAGCTGCTCTGGTTGCCAGCCTCCTACTTGCCAGCCAGG CTGGTGGATGCTGTGCTCGCCTGGGTCCTTCCCAAGCCTGCCCAGACAGTCTACTAA 318 35037.0 9.1 1-23 289-309 None >11-cis retinol dehydrogenase MWLPLLLGVLLWAALWLLRDRQCLPASDAFIFITGCDSGFGRLLALRLDQRGFRVLASCL TPSGAEDLQRVASSRLHTTLLDVTDPQSIRQAVKWVETHVGEAGLFGLVNNAGVAGIIGP TPWQTREDFQRVLNVNTLGPIGVTLALLPLLLQARGRVINITSVLGRLAANGGGYCVSKF GLEAFSDSLRRDVAPFGVRVSIVEPGFFRTPVTNLETLEDTLQACWARLPPATQALYGEA FLTKYLRVQQRIMNMICDPDLAKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAR LVDAVLAWVLPKPAQTVY AAA80694.1 Q27979 RDH5_BOVIN L36533 RDH5